Summary of project PR000007
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000007. The data can be accessed directly via it's Project DOI: 10.21228/M87P4G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000007 |
| Project DOI: | doi: 10.21228/M87P4G |
| Project Title: | Population Genetics (PopGen) for Response to Cholera Vaccination) |
| Project Type: | Vaccine Response |
| Project Summary: | A two-dose killed cholera vaccine was orally administered 14 days apart (day 0 and day 14). Each dose of the vaccine contained 600 ELISA Units (EU) of lipopolysaccharide (LPS) of formalin-killed V. cholerae Inaba, El Tor biotype (Phil 6973); 300 EU LPS of heat-killed V. cholerae Ogawa classical biotype (Cairo 50); 300 EU LPS of heat-killed V. cholerae Inaba, classical biotype (Cairo 48); and 600 EU LPS of formalin killed V. cholerae O139 (4260B). The vaccine was procured from Shantha Biotechnics, Hyderabad, India and approval for administration of the vaccine was given by the Drug Controller General, Government of India. From each study participant, a blood sample was collected immediately prior to vaccination (Day-0 sample) and 28-days post-vaccination (Day-28 sample). Association between single-nucleotide polymorphic (SNP) loci in and around 296 immunologically relevant genes and total anti-lipopolysaccharide (LPS) antibody response to a killed whole-cell vaccine, comprising LPS from multiple strains of Vibrio cholerae has been investigated. Titers derived from standard vibriocidal assays were also analyzed to gain further insights on validated SNP associations. Reference: Majumder,P. P.et. al. 2012. Genomic Correlates of Variability in Immune Response to an Oral Cholera Vaccine, European Journal of Human Genetics, 1-7. |
| Institute: | RTI International |
| Department: | Social, Statistical, and Environmental Sciences (SSES) |
| Laboratory: | Genomics and Molecular Epidemiology |
| Last Name: | Wagener |
| First Name: | Diane |
| Address: | 500 W Harbor Drive, #1114, San Diego, CA 92101, USA |
| Email: | dwagener@rti.org |
| Funding Source: | NIAID |
Summary of all studies in project PR000007
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000008 (Availability TBA) | Metabolomics Analysis of Population Genetics (PopGen) for Response to Cholera Vaccination) | Homo sapiens | University of North Carolina | NMR | - | - | 112 | Not available |
