Data for Metabolomics Analysis of Frontal Fibrosing Alopecia (Study ST000093)
(Analysis AN000148)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 1-linoleoylglycerophosphocholine | 1.3069 | 0.8642 | 0.6577 |
| 1-oleoylglycerophosphocholine | 1.3759 | 0.9083 | 0.4317 |
| 1-palmitoylglycerophosphocholine | 1.4052 | 0.8870 | 0.4155 |
| 1-stearoylglycerophosphocholine | 1.3477 | 0.9234 | 0.4578 |
| 2-aminoadipate | 1.0368 | 1.0645 | 0.7976 |
| 2-methylbutyroylcarnitine | 0.7465 | 1.1880 | 1.1310 |
| 2-oleoylglycerophosphocholine* | 1.5387 | 0.6714 | 0.5798 |
| 3-dehydrocarnitine* | 0.8280 | 0.8789 | 1.5863 |
| 4-acetamidobutanoate | 1.2097 | 0.8891 | 0.8025 |
| 4-guanidinobutanoate | 0.8549 | 0.9641 | 1.3621 |
| 5-methylthioadenosine (MTA) | 1.0861 | 1.0978 | 0.6321 |
| acetylcarnitine | 0.9069 | 1.0158 | 1.1546 |
| acetylcholine | 1.1035 | 0.9643 | 0.8644 |
| adenosine | 0.8506 | 1.1378 | 1.0232 |
| adenosine 5^-monophosphate (AMP) | 1.0228 | 1.0464 | 0.8615 |
| ADSGEGDFXAEGGGVR* | 1.1154 | 0.9226 | 0.9240 |
| alanylleucine | 1.0697 | 0.7510 | 1.3585 |
| alanylphenylalanine | 1.0556 | 0.7795 | 1.3299 |
| alanylvaline | 1.0040 | 1.0236 | 0.9448 |
| arginine | 0.9944 | 0.9977 | 1.0158 |
| betaine | 0.9997 | 0.9433 | 1.1139 |
| butyrylcarnitine | 0.8179 | 1.2142 | 0.9357 |
| caffeine | 0.9301 | 0.9807 | 1.1784 |
| carnitine | 1.0066 | 1.0112 | 0.9643 |
| C-glycosyltryptophan* | 1.0170 | 1.0151 | 0.9358 |
| choline | 1.0011 | 0.9806 | 1.0366 |
| choline phosphate | 0.9559 | 1.0637 | 0.9608 |
| cis-urocanate | 1.0685 | 0.9130 | 1.0371 |
| citrulline | 1.1380 | 0.9255 | 0.8730 |
| creatine | 0.9763 | 1.0438 | 0.9598 |
| creatinine | 0.9839 | 0.9589 | 1.1144 |
| cysteine-glutathione disulfide | 1.2430 | 0.9703 | 0.5732 |
| cytidine | 1.0033 | 0.9259 | 1.1415 |
| cytidine 5^-monophosphate (5^-CMP) | 1.0706 | 0.9932 | 0.8723 |
| deoxycarnitine | 1.1154 | 1.0222 | 0.7249 |
| dexpanthenol | 1.7841 | 0.4045 | 0.6228 |
| dimethylarginine (SDMA + ADMA) | 0.9573 | 1.0174 | 1.0505 |
| doxycycline | 1.0000 | 1.0000 | 1.0000 |
| ergothioneine | 1.1836 | 1.1089 | 0.4150 |
| fluoxetine | 0.7429 | 0.7321 | 2.0500 |
| gabapentin | 0.7889 | 0.7984 | 1.8255 |
| gamma-glutamylisoleucine* | 1.1945 | 0.8410 | 0.9290 |
| gamma-glutamylleucine | 1.2839 | 0.8715 | 0.6892 |
| gamma-glutamyltyrosine | 1.0638 | 0.9369 | 0.9985 |
| gamma-glutamylvaline | 1.1196 | 0.8792 | 1.0024 |
| glutamate | 1.0429 | 0.9686 | 0.9769 |
| glutamate, gamma-methyl ester | 0.9978 | 0.9451 | 1.1143 |
| glutamine | 0.9625 | 0.9856 | 1.1040 |
| glutaroyl carnitine | 1.1533 | 0.9070 | 0.8794 |
| glutathione, oxidized (GSSG) | 1.0272 | 1.1433 | 0.6592 |
| glutathione, reduced (GSH) | 0.5937 | 0.7546 | 2.3034 |
| glycerophosphorylcholine (GPC) | 1.0106 | 0.9952 | 0.9884 |
| glycylisoleucine | 1.1875 | 0.8208 | 0.9833 |
| glycylleucine | 1.2609 | 0.7331 | 1.0121 |
| glycylproline | 1.0859 | 0.8470 | 1.1343 |
| glycyltyrosine | 1.1144 | 1.0414 | 0.6882 |
| glycylvaline | 1.2133 | 0.8597 | 0.8542 |
| guanosine 5^- monophosphate (5^-GMP) | 1.0827 | 0.9922 | 0.8501 |
| heme* | 1.2131 | 0.9202 | 0.7333 |
| hexanoylcarnitine | 0.8581 | 1.0380 | 1.2078 |
| histamine | 1.1273 | 0.8550 | 1.0352 |
| hydroxyisovaleroyl carnitine | 0.4775 | 0.8174 | 2.4102 |
| ibuprofen acyl glucuronide | 1.0158 | 0.9894 | 0.9894 |
| imidazole propionate | 0.8036 | 1.0108 | 1.3712 |
| indoleacetate | 1.0761 | 1.0611 | 0.7254 |
| isobutyrylcarnitine | 0.7795 | 1.2076 | 1.0257 |
| isoleucine | 1.0510 | 0.9493 | 0.9994 |
| isoleucylglycine | 0.9403 | 1.0609 | 0.9977 |
| isovalerylcarnitine | 0.6783 | 1.0684 | 1.5066 |
| kynurenine | 1.2430 | 0.8946 | 0.7248 |
| leucine | 1.0427 | 0.9631 | 0.9885 |
| leucylglycine | 1.0869 | 0.9177 | 0.9908 |
| lidocaine | 0.7673 | 0.7766 | 1.9124 |
| lysine | 1.0543 | 0.9779 | 0.9354 |
| malonylcarnitine | 0.6841 | 1.2147 | 1.2025 |
| methionine | 1.0315 | 0.9922 | 0.9525 |
| N1-Methyl-2-pyridone-5-carboxamide | 1.1548 | 0.9320 | 0.8264 |
| N1-methyladenosine | 0.8990 | 1.0894 | 1.0232 |
| N6-acetyllysine | 1.1784 | 0.9071 | 0.8290 |
| N-acetylaspartate (NAA) | 1.2072 | 0.9453 | 0.6950 |
| N-acetyl-aspartyl-glutamate (NAAG) | 1.0881 | 1.0601 | 0.7036 |
| N-acetylornithine | 1.1635 | 0.9569 | 0.7593 |
| naproxen | 1.0000 | 1.0000 | 1.0000 |
| N-ethylglycinexylidide* | 0.6992 | 0.7287 | 2.1443 |
| nicotinamide | 1.2900 | 0.7420 | 0.9361 |
| nicotinamide adenine dinucleotide (NAD+) | 0.9803 | 1.1236 | 0.7921 |
| nicotinamide ribonucleotide (NMN) | 0.9380 | 0.9448 | 1.2343 |
| nicotinamide riboside* | 0.9929 | 0.9350 | 1.1441 |
| norfluoxetine* | 0.5563 | 0.5505 | 2.7864 |
| normetanephrine | 0.9780 | 1.0116 | 1.0208 |
| octanoylcarnitine | 0.9637 | 0.8994 | 1.2739 |
| ophthalmate | 1.1302 | 0.9272 | 0.8851 |
| pantothenate | 1.1222 | 1.1432 | 0.4692 |
| paraxanthine | 0.9396 | 0.8862 | 1.3484 |
| phenylalanine | 1.0463 | 0.9921 | 0.9231 |
| pipecolate | 1.1205 | 1.1279 | 0.5031 |
| piperine | 1.1007 | 0.9311 | 0.9365 |
| proline | 0.9949 | 1.0187 | 0.9727 |
| propionylcarnitine | 0.7793 | 1.0519 | 1.3376 |
| pyroglutamine* | 0.8616 | 0.9645 | 1.3477 |
| serylphenyalanine | 1.0750 | 0.9128 | 1.0243 |
| spermidine | 0.8561 | 1.0097 | 1.2684 |
| sphingosine | 1.2940 | 0.8823 | 0.6474 |
| stachydrine | 0.8802 | 0.8851 | 1.4693 |
| theobromine | 1.0398 | 1.0446 | 0.8312 |
| threonine | 1.0467 | 0.9762 | 0.9542 |
| tiglyl carnitine | 0.7183 | 1.2215 | 1.1205 |
| topiramate | 0.8162 | 0.8162 | 1.7354 |
| trans-4-hydroxyproline | 0.9858 | 1.0008 | 1.0269 |
| trans-urocanate | 0.9892 | 1.0468 | 0.9281 |
| tryptophan | 1.0098 | 1.0212 | 0.9380 |
| tryptophan betaine | 0.9258 | 1.0083 | 1.1318 |
| tyrosine | 1.0138 | 1.0037 | 0.9651 |
| valerylcarnitine | 0.7249 | 1.1464 | 1.2575 |
| valine | 1.0078 | 1.0009 | 0.9826 |
Factors:
| F1 | condition:FFA affected | location:frontal scalp |
| F2 | condition:FFA unaffected | location:occipital scalp |
| F3 | condition:Scalp biopsy normal | location:NA |
