Data for Metabolomics Analysis of Frontal Fibrosing Alopecia (Study ST000093)

(Analysis AN000149)

Values for each metabolite have been scaled by dividing by the mean across all factors

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Metabolite	F1	F2	F3
10-heptadecenoate (17:1n7)	1.0675	0.9692	0.9265
10-nonadecenoate (19:1n9)	1.1371	0.8455	1.0348
15-methylpalmitate (isobar with 2-methylpalmitate)	0.9659	1.1158	0.8365
17-methylstearate	0.9168	1.0691	1.0283
1-arachidonoylglycerophosphoethanolamine*	1.1128	0.9512	0.8721
1-arachidonoylglycerophosphoinositol*	1.1116	0.9099	0.9569
1-linoleoylglycerophosphoethanolamine*	1.0750	0.9810	0.8880
1-oleoylglycerophosphoethanolamine	1.1861	0.8587	0.9105
1-palmitoylglycerophosphoethanolamine	1.1744	0.9008	0.8496
1-palmitoylglycerophosphoinositol*	1.1167	0.9959	0.7748
1-palmitoylplasmenylethanolamine*	1.0577	0.8989	1.0868
1-stearoylglycerophosphoethanolamine	1.2565	0.7859	0.9152
1-stearoylglycerophosphoinositol	1.1124	1.0238	0.7276
2,3-diphosphoglycerate	1.0705	1.1667	0.5256
2-arachidonoylglycerophosphoethanolamine*	1.0013	0.9053	1.1868
2-ethylhexanoate (isobar with 2-propylpentanoate)	1.2598	1.0261	0.4282
2-hydroxyacetaminophen sulfate*	1.0533	1.0541	0.7852
2-hydroxyhippurate (salicylurate)	1.1785	1.1943	0.2544
2-hydroxypalmitate	0.9956	1.0038	1.0012
2-hydroxystearate	0.9634	1.0227	1.0278
2-linoleoylglycerophosphoethanolamine*	0.9696	0.9648	1.1311
2-methoxyacetaminophen sulfate*	1.0100	0.9933	0.9933
2-oleoylglycerophosphoethanolamine*	1.0791	0.9058	1.0302
2-palmitoylglycerophosphoethanolamine*	1.2049	0.8757	0.8388
3-(4-hydroxyphenyl)lactate	1.0232	1.0380	0.8776
3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF)	1.3421	1.0468	0.2221
3-indoxyl sulfate	1.0580	1.0073	0.8695
3-methyl-2-oxobutyrate	1.0116	1.0476	0.8816
3-methyl-2-oxovalerate	0.9150	1.1648	0.8404
4-acetaminophen sulfate	1.0694	1.0663	0.7287
4-androsten-3beta,17beta-diol disulfate 1*	0.9624	0.8627	1.3500
4-methyl-2-oxopentanoate	0.9160	1.1791	0.8097
5alpha-pregnan-3beta,20alpha-diol disulfate	1.0175	0.9883	0.9883
5-oxoproline	1.0193	0.9972	0.9669
6-phosphogluconate	0.8963	0.9146	1.3781
7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca)	1.2261	0.9365	0.6748
adenosine 2^-monophosphate (2^-AMP)	0.8352	1.1113	1.1071
adenosine 3^,5^-cyclic monophosphate (cAMP)	0.8586	0.7874	1.7080
adenosine 5^diphosphoribose	0.9842	1.0774	0.8769
adrenate (22:4n6)	1.0962	0.8388	1.1300
androsterone sulfate	0.9940	0.9522	1.1077
arachidonate (20:4n6)	1.1522	0.8337	1.0281
bisphenol A monosulfate	1.0000	1.0000	1.0000
caprate (10:0)	1.2215	1.1100	0.3370
caproate (6:0)	1.2238	1.0277	0.4970
caprylate (8:0)	1.2571	1.1348	0.2162
catechol sulfate	1.0714	1.0994	0.6584
dehydroisoandrosterone sulfate (DHEA-S)	0.9889	0.9581	1.1061
deoxycholate	1.0602	0.9337	1.0122
dihomo-linoleate (20:2n6)	1.1802	0.7787	1.0823
dihomo-linolenate (20:3n3 or n6)	1.2416	0.7863	0.9443
docosadienoate (22:2n6)	1.0626	0.8880	1.0988
docosahexaenoate (DHA; 22:6n3)	1.2425	0.9177	0.6796
docosapentaenoate (n3 DPA; 22:5n3)	1.2115	0.9231	0.7309
docosapentaenoate (n6 DPA; 22:5n6)	0.9706	0.7598	1.5392
docosatrienoate (22:3n3)	1.2668	0.6114	1.2436
eicosapentaenoate (EPA; 20:5n3)	1.0721	1.0172	0.8214
eicosenoate (20:1n9 or 11)	1.1465	0.8384	1.0302
flavin adenine dinucleotide (FAD)	1.0806	1.0497	0.7394
glycocholate	1.0393	1.0274	0.8667
guanosine	1.0244	0.9477	1.0558
heptanoate (7:0)	1.1917	1.0413	0.5339
hippurate	0.9763	0.9778	1.0919
histidine	1.0838	0.9270	0.9785
hydroxypioglitazone*	1.0000	1.0000	1.0000
hypoxanthine	1.0359	0.9449	1.0382
ibuprofen	1.0297	0.9802	0.9802
inosine	1.0784	0.8505	1.1423
Isobar: fructose 1,6-diphosphate, glucose 1,6-diphosphate, myo-inositol 1,4 or 1,3-diphosphate	0.9275	1.0523	1.0403
laurate (12:0)	1.1495	1.1045	0.4921
linoelaidate (tr 18:2n6)	1.0894	0.9333	0.9545
linoleate (18:2n6)	1.0810	0.9546	0.9289
linolenate [alpha or gamma; (18:3n3 or 6)]	1.1474	0.9177	0.8698
margarate (17:0)	1.0191	1.0100	0.9418
mead acid (20:3n9)	1.1082	0.8920	0.9995
myristate (14:0)	1.0628	1.0709	0.7327
myristoleate (14:1n5)	1.2165	1.0330	0.5012
N-(2-furoyl)glycine	1.0558	0.9896	0.9093
N-acetylalanine	0.8859	1.1631	0.9020
N-acetylmethionine	0.9377	1.0501	1.0244
N-acetylthreonine	0.8977	1.1031	0.9984
nicotinamide adenine dinucleotide reduced (NADH)	0.8284	1.0241	1.2950
nonadecanoate (19:0)	0.9452	1.0548	1.0000
oleate (18:1n9)	1.0768	0.9573	0.9318
oleic ethanolamide	0.9184	1.1342	0.8948
p-acetamidophenylglucuronide	0.9976	1.0036	0.9976
palmitate (16:0)	1.0312	1.0158	0.9060
palmitoleate (16:1n7)	1.0934	1.0350	0.7432
palmitoyl ethanolamide	1.1251	0.8926	0.9647
p-cresol sulfate	1.0742	0.9861	0.8793
pelargonate (9:0)	1.2539	1.1202	0.2518
phenol sulfate	1.1569	1.1346	0.4172
phenylacetylglutamine	0.9670	1.0065	1.0529
phenyllactate (PLA)	1.0653	0.9546	0.9601
phosphoethanolamine	1.0430	1.0124	0.8892
pregnen-diol disulfate*	0.7941	0.7711	1.8697
pseudouridine	0.8974	1.0587	1.0880
pyridoxate	1.2732	1.1286	0.1964
pyroglutamylvaline	1.0970	0.9275	0.9510
ricinoleic acid	1.0000	1.0000	1.0000
S-adenosylhomocysteine (SAH)	0.9519	0.9818	1.1325
taurochenodeoxycholate	1.0645	1.0113	0.8484
taurodeoxycholate	1.0751	0.9676	0.9145
undecanoate (11:0)	1.0898	1.1888	0.4428
urate	0.9188	1.0046	1.1532
uridine	0.9746	0.9657	1.1193
uridine monophosphate (5^ or 3^)	1.0538	0.9813	0.9297
VGAHAGEYGAEALER*	0.9047	0.4744	2.2418

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Factors:

F1	condition:FFA affected | location:frontal scalp
F2	condition:FFA unaffected | location:occipital scalp
F3	condition:Scalp biopsy normal | location:NA