Data for Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure (Study ST000166)
(Analysis AN000259)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 2-HB (2-hydroxybutyric acid) | 0.7472 | 0.4296 | 1.4364 | 1.2720 | 0.6041 | 1.0997 |
| 2-hydroxypyridine | 1.2767 | 1.1854 | 0.8250 | 0.6873 | 1.0539 | 1.0588 |
| 3-AIB (a-amino[1-(14)C]isobutyric acid) | 1.1290 | 1.3947 | 0.7850 | 0.7784 | 0.5581 | 1.0573 |
| 3-HB (3-hydroxybutyric acid) | 1.0838 | 1.2660 | 0.8524 | 0.8625 | 0.6746 | 1.0371 |
| Acetate | 1.2820 | 1.5845 | 0.7141 | 0.6426 | 0.7702 | 0.9245 |
| Acetoacetate | 1.1476 | 1.3265 | 0.7968 | 0.9121 | 0.8488 | 0.8988 |
| Acetone | 1.1072 | 1.1983 | 0.7991 | 0.8489 | 0.6816 | 1.1319 |
| Acetylsalicylic acid | 1.2494 | 1.0430 | 0.1257 | 1.5103 | 0.0563 | 1.1942 |
| Alanine | 1.1900 | 1.4582 | 0.9173 | 0.6310 | 0.8772 | 0.9189 |
| Allo-inositol | 1.1650 | 1.4291 | 0.5147 | 0.7857 | 0.5391 | 1.2383 |
| Arabitol | 0.9180 | 1.6776 | 0.5296 | 0.9537 | 0.3318 | 1.1156 |
| Benzoic acid | 0.6538 | 0.3584 | 1.4914 | 1.0312 | 0.4236 | 1.4665 |
| Beta- alanine | 1.2774 | 0.9761 | 0.9462 | 0.7701 | 1.2411 | 1.0023 |
| Cholesterol | 1.0570 | 1.0378 | 1.1511 | 0.8996 | 0.8817 | 0.9017 |
| Citrate | 1.2715 | 1.6288 | 0.5863 | 0.7784 | 0.2572 | 0.9715 |
| Creatine | 1.1568 | 1.3265 | 0.7548 | 0.8834 | 0.8642 | 0.9545 |
| Creatinine | 1.2044 | 1.4134 | 0.6898 | 0.8552 | 0.8347 | 0.9328 |
| Creatinine g | 0.9160 | 1.2246 | 0.5799 | 1.1172 | 0.7667 | 1.1997 |
| Cysteine | 1.0290 | 1.1190 | 1.2610 | 0.7251 | 0.7121 | 0.9662 |
| Fumaric acid | 0.9721 | 1.4523 | 0.5981 | 0.8710 | 0.4131 | 1.2563 |
| Galactinol | 2.3951 | 1.4213 | 0.5113 | 0.4866 | 0.5896 | 0.4194 |
| Galacturonic acid | 0.1822 | 0.1822 | 0.5246 | 1.5822 | 0.4970 | 2.3541 |
| Gluconic acid | 0.2074 | 0.2074 | 0.7614 | 1.2848 | 0.2074 | 2.4453 |
| Glucose_A | 1.0632 | 1.1657 | 0.9658 | 0.8964 | 0.9404 | 0.9524 |
| Glucose_beta | 0.9927 | 1.1802 | 0.9588 | 0.9990 | 0.7011 | 0.9520 |
| Glutamic acid | 0.6086 | 0.6205 | 0.4340 | 1.7376 | 0.7102 | 1.4959 |
| Glutamic acid (dehydrated) | 1.0155 | 1.0070 | 1.1007 | 0.9110 | 0.8958 | 0.9965 |
| Glutamine | 1.2312 | 1.4362 | 0.8342 | 0.7158 | 0.9105 | 0.8841 |
| Glyceric acid | 1.1995 | 0.7809 | 0.6222 | 1.5555 | 1.0297 | 0.7804 |
| Glycerol | 0.6608 | 0.6037 | 1.9216 | 0.8439 | 0.6282 | 1.0185 |
| Glycerol -1-P | 1.3080 | 1.2190 | 1.0058 | 0.7782 | 0.7275 | 0.8069 |
| Glycine | 0.9825 | 1.1715 | 1.2881 | 0.7993 | 0.7518 | 0.8595 |
| Glycolic acid | 1.2100 | 1.0710 | 0.8934 | 0.9128 | 0.6216 | 1.0040 |
| Heptadecanoic acid | 0.3544 | 0.3544 | 1.8003 | 1.1615 | 1.4499 | 1.1443 |
| Iminodiacetic acid | 0.9915 | 1.0694 | 0.9434 | 1.0100 | 0.9337 | 1.0045 |
| Isoleucine | 1.1297 | 1.2591 | 0.8736 | 0.8467 | 0.8272 | 0.9696 |
| Isopropyl beta--thiogalactopyranoside | 0.9538 | 1.2210 | 1.1022 | 0.8720 | 0.7667 | 0.9387 |
| Lactate | 1.0821 | 1.0996 | 1.0270 | 0.7963 | 0.8073 | 1.0580 |
| Leucine | 1.1225 | 1.2610 | 0.8729 | 0.8458 | 0.8056 | 0.9802 |
| Linoleic acid | 0.6930 | 0.5508 | 1.8518 | 1.0105 | 0.7241 | 0.9119 |
| Lysine | 1.2638 | 0.8767 | 0.9310 | 0.9777 | 0.2438 | 1.0836 |
| Malic acid | 0.3388 | 0.3388 | 0.8450 | 1.4571 | 2.1293 | 1.6205 |
| Malonate | 1.5261 | 0.9585 | 0.6502 | 1.0657 | 0.8466 | 0.8359 |
| Mannitol | 1.0936 | 1.1092 | 1.1250 | 1.2405 | 0.0660 | 0.6412 |
| Melezitose | 0.0961 | 0.0961 | 1.4711 | 1.3830 | 0.0961 | 1.9143 |
| Methylamine | 1.3851 | 1.7672 | 0.6058 | 0.3882 | 0.4061 | 1.1005 |
| Methylguanidine | 1.0484 | 1.3052 | 1.2174 | 0.5614 | 2.0369 | 0.7587 |
| Myristic acid | 0.4798 | 0.4829 | 1.6560 | 1.1927 | 0.7299 | 1.1560 |
| Nicotinic acid | 0.5188 | 0.6904 | 1.4148 | 1.0057 | 1.8047 | 1.1617 |
| N-methylhistidine | 1.7554 | 1.8482 | 0.4653 | 0.5475 | 0.6610 | 0.6195 |
| Norleucine | 1.0346 | 1.2217 | 0.8997 | 1.0743 | 0.5619 | 0.8837 |
| Norvaline | 0.9179 | 0.9979 | 1.0631 | 1.0276 | 0.4674 | 1.0882 |
| Oleic acid | 0.5447 | 0.4665 | 1.4971 | 1.3193 | 0.7744 | 1.1201 |
| Ornithine | 1.1046 | 1.0805 | 0.9488 | 1.0191 | 0.7484 | 0.9123 |
| Oxalic acid | 1.7119 | 1.2393 | 0.5997 | 0.6241 | 1.0692 | 0.8842 |
| Palmitic acid | 0.7639 | 0.6918 | 1.3305 | 1.1189 | 0.8142 | 1.0814 |
| Palmitoleic acid | 0.3724 | 0.3292 | 1.8110 | 1.3771 | 0.4814 | 1.0993 |
| Phenylalanine | 2.3768 | 1.1482 | 0.5920 | 0.6114 | 0.7455 | 0.4330 |
| Phosphoric acid | 1.0407 | 1.1100 | 0.9812 | 0.9060 | 0.9545 | 0.9923 |
| Porphine | 1.3263 | 1.2287 | 0.7335 | 0.6648 | 0.9959 | 1.0945 |
| Proline | 1.0901 | 1.4520 | 0.7563 | 0.9125 | 0.7170 | 0.9087 |
| Pyrophosphate | 1.6226 | 1.8241 | 0.3119 | 0.7064 | 0.3278 | 0.8012 |
| Pyruvic acid | 1.0379 | 0.8334 | 1.1485 | 1.0783 | 0.6742 | 0.9477 |
| Serine | 0.9348 | 0.7908 | 1.4174 | 1.0603 | 0.8229 | 0.8229 |
| Serotonin | 0.5636 | 0.6252 | 1.6219 | 0.9631 | 0.9142 | 1.1906 |
| Stearic acid | 0.8852 | 0.7479 | 1.1489 | 1.0678 | 0.9642 | 1.1139 |
| Succinate | 1.2534 | 1.5567 | 0.8962 | 0.5803 | 0.6566 | 0.8906 |
| Sucrose | 2.1453 | 1.9014 | 0.0599 | 0.2327 | 0.2657 | 0.9767 |
| Tagatose | 0.1397 | 0.1397 | 0.4606 | 1.2478 | 7.9147 | 1.4715 |
| Threitol | 1.0606 | 1.2930 | 0.4808 | 1.0691 | 0.4826 | 1.2022 |
| Threonine | 0.9757 | 0.9887 | 1.3950 | 0.8644 | 0.7413 | 0.8548 |
| Tryptophan | 0.2717 | 0.2717 | 0.8619 | 1.3923 | 1.1701 | 1.9604 |
| Tyrosine | 1.6794 | 2.1506 | 0.4891 | 0.5175 | 0.5643 | 0.4671 |
| Urea | 0.9673 | 1.2735 | 0.7194 | 1.0845 | 0.6050 | 1.0484 |
| Uric acid | 0.9966 | 1.2271 | 0.4679 | 1.1374 | 0.3534 | 1.2812 |
| Valine | 1.1249 | 1.3032 | 0.8727 | 0.8195 | 0.7754 | 0.9754 |
Factors:
| F1 | Group:3M | State:Res |
| F2 | Group:3M | State:Unres |
| F3 | Group:Control | State:Control |
| F4 | Group:HF | State:Res |
| F5 | Group:HF | State:uc |
| F6 | Group:HF | State:Unres |
