Data for Glycolysis/TCA/Nucleotide_Wt_KO_TimeCourse_LPS (Study ST000209)
(Analysis AN000311)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 or 3-phosphoglycerate_2PG/3PG | 0.2392 | 0.2341 | 0.9144 | 1.3243 | 1.1620 | 1.0983 | 1.1283 | 1.7255 | 0.6453 | 1.3257 | 0.8193 | 1.3835 |
| Acetyl-CoA | 0.5125 | 0.4516 | 0.9408 | 1.2469 | 1.2127 | 1.5499 | 2.0523 | 1.4258 | 0.5035 | 0.7011 | 0.5812 | 0.8218 |
| ADP | 0.8462 | 0.8096 | 0.9976 | 1.1948 | 1.1948 | 0.8450 | 1.1869 | 0.8398 | 0.8624 | 1.1943 | 0.9290 | 1.0996 |
| AMP | 1.3175 | 0.9512 | 0.7104 | 0.7447 | 1.0906 | 0.5129 | 0.8060 | 0.4105 | 1.6923 | 0.9164 | 1.8761 | 0.9714 |
| ATP | 0.9663 | 1.1392 | 0.9614 | 1.0520 | 0.8820 | 0.9310 | 1.1939 | 0.9099 | 0.7597 | 1.1975 | 0.8046 | 1.2026 |
| Citrate or Isocitrate | 0.9105 | 0.7129 | 1.1258 | 0.9115 | 1.1308 | 0.7721 | 1.0695 | 0.9445 | 0.9623 | 1.5017 | 0.9264 | 1.0321 |
| Erythrose 4-phosphate | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| flavin adenine dinucleotide | 0.9235 | 1.1712 | 1.0082 | 1.0070 | 1.0726 | 0.8745 | 1.1535 | 0.7511 | 0.9314 | 1.1632 | 0.8114 | 1.1325 |
| Fructose 1,6-bisphosphate | 0.6450 | 0.6224 | 0.9416 | 1.3780 | 0.9704 | 0.9805 | 1.0751 | 1.2287 | 0.7966 | 1.3387 | 0.8162 | 1.2069 |
| Glucose 6-phosphate or fructose-6-phosphate | 0.5158 | 0.5759 | 0.7482 | 1.2254 | 1.0800 | 1.1465 | 1.2463 | 1.4612 | 0.7653 | 1.2070 | 0.7704 | 1.2582 |
| Malate | 0.7504 | 0.6792 | 1.0573 | 0.8390 | 1.1090 | 0.7319 | 1.0644 | 0.6613 | 1.1053 | 1.7944 | 1.1389 | 1.0689 |
| Nicotinamide Adenine Dinucleotide oxidized | 0.9203 | 0.9730 | 1.0376 | 1.0249 | 0.7681 | 0.9372 | 0.8651 | 0.8104 | 0.9477 | 1.8298 | 0.8795 | 1.0064 |
| nicotinamide adenine dinucleotide phosphate oxidized | 1.0312 | 0.9295 | 1.0114 | 1.0323 | 1.0407 | 0.8767 | 1.1312 | 0.8628 | 0.9476 | 1.0630 | 1.0068 | 1.0669 |
| nicotinamide adenine dinucleotide phosphate reduced | 1.0968 | 1.0409 | 1.0191 | 0.9487 | 0.8088 | 0.8617 | 1.1437 | 0.7260 | 0.9200 | 1.2556 | 0.9827 | 1.1960 |
| Nicotinamide Adenine Dinucleotide reduced | 0.5110 | 0.6248 | 0.9782 | 1.0805 | 0.7440 | 0.8306 | 0.8821 | 0.9253 | 0.8085 | 1.9639 | 0.9445 | 1.7068 |
| Phosphoenolpyruvate | 0.0281 | 0.0499 | 1.0809 | 1.4331 | 1.6384 | 1.7840 | 2.3183 | 2.4361 | 0.0717 | 0.2119 | 0.3646 | 0.5829 |
| Ribose-5-phosphate or xylulose 5-phosphate | 0.4200 | 0.3731 | 1.0573 | 0.7160 | 2.2422 | 0.7459 | 1.5243 | 1.0286 | 0.9471 | 0.5718 | 1.6331 | 0.7406 |
| Sedoheptulose 7-phosphate | 0.3376 | 0.4097 | 0.6866 | 1.6431 | 1.0289 | 1.7371 | 1.3324 | 2.0107 | 0.4165 | 0.9213 | 0.4745 | 1.0015 |
| Sucrose | 0.0979 | 0.1217 | 1.0104 | 1.4930 | 1.4736 | 1.7913 | 2.1853 | 2.3292 | 0.1217 | 0.2654 | 0.4105 | 0.7000 |
Factors:
| F1 | time course:0h | Cell type:KO macrophage | Treatment:untreated |
| F2 | time course:0h | Cell type:Wt macrophage | Treatment:untreated |
| F3 | time course:12h | Cell type:KO macrophage | Treatment:LPS |
| F4 | time course:12h | Cell type:Wt macrophage | Treatment:LPS |
| F5 | time course:18h | Cell type:KO macrophage | Treatment:LPS |
| F6 | time course:18h | Cell type:Wt macrophage | Treatment:LPS |
| F7 | time course:24h | Cell type:KO macrophage | Treatment:LPS |
| F8 | time course:24h | Cell type:Wt macrophage | Treatment:LPS |
| F9 | time course:3h | Cell type:KO macrophage | Treatment:LPS |
| F10 | time course:3h | Cell type:Wt macrophage | Treatment:LPS |
| F11 | time course:6h | Cell type:KO macrophage | Treatment:LPS |
| F12 | time course:6h | Cell type:Wt macrophage | Treatment:LPS |
