Data for Isocitrate dehydrogenase-1/Glioma Fluxomics Study (Study ST000302)
(Analysis AN000481)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FA_14:0_Me | 0.9514 | 1.6787 | 0.4730 | 0.7272 | 0.9854 | 0.8400 | 1.1697 | 1.3145 | 0.6672 | 1.2639 | 0.6740 | 1.3429 |
| FA_14:0_Me_13C_1 | 0.1690 | 0.3049 | 0.5293 | 0.3380 | 1.9756 | 1.6015 | 0.1593 | 0.1936 | 0.8970 | 0.1551 | 1.4465 | 2.8989 |
| FA_14:0_Me_13C_10 | NA | NA | 1.4324 | 0.5600 | 1.3024 | 0.7340 | NA | NA | 1.3273 | 1.2651 | 0.7728 | 0.6943 |
| FA_14:0_Me_13C_2 | 0.0030 | 0.0183 | 1.0479 | 0.0474 | 3.1399 | 1.9595 | 0.0105 | 0.0262 | 1.6462 | 0.0967 | 1.5136 | 1.5275 |
| FA_14:0_Me_13C_3 | NA | NA | 0.9166 | 0.1094 | 2.0206 | 1.1822 | NA | NA | 1.2268 | 0.0937 | 0.8821 | 0.9697 |
| FA_14:0_Me_13C_4 | NA | NA | 1.3759 | 0.1133 | 2.0868 | 1.0413 | NA | NA | 1.3819 | 0.1453 | 0.8503 | 0.7204 |
| FA_14:0_Me_13C_5 | NA | NA | 1.5124 | 0.1580 | 1.7754 | 0.9478 | NA | NA | 1.4235 | 0.3955 | 0.9277 | 0.6582 |
| FA_14:0_Me_13C_6 | NA | NA | 1.6914 | 0.2709 | 1.8049 | 0.8293 | NA | NA | 1.4116 | 0.4161 | 0.7536 | 0.6276 |
| FA_14:0_Me_13C_7 | NA | NA | 1.1919 | 0.3398 | 1.3289 | 0.9443 | NA | NA | 1.2772 | 0.8795 | 0.9455 | 1.0528 |
| FA_14:0_Me_13C_8 | NA | NA | 1.7522 | 0.4060 | 1.5451 | 0.7648 | NA | NA | 1.2877 | 0.7748 | 0.7090 | 0.6852 |
| FA_14:0_Me_13C_9 | NA | NA | 1.0820 | NA | 1.0535 | 1.0131 | NA | NA | 1.2220 | NA | 0.7826 | 0.8467 |
| FA_16:0_Me | 0.8236 | 1.4571 | 0.5535 | 0.7128 | 0.8710 | 0.7129 | 1.2418 | 1.3564 | 0.8975 | 1.5192 | 0.7631 | 1.2642 |
| FA_16:0_Me_13C_1 | 0.2792 | 0.5798 | 0.4067 | 0.2104 | 1.5921 | 1.5906 | 0.4415 | 0.5079 | 1.0387 | 0.5484 | 1.6047 | 3.0494 |
| FA_16:0_Me_13C_10 | NA | 0.1104 | 1.6771 | 0.2294 | 1.6189 | 1.0151 | NA | 0.1482 | 1.6537 | 0.6990 | 1.3182 | 1.4296 |
| FA_16:0_Me_13C_2 | 0.0008 | 0.0102 | 0.7945 | 0.0210 | 2.4579 | 1.9814 | 0.0027 | 0.0054 | 1.5134 | 0.0353 | 1.7866 | 2.0705 |
| FA_16:0_Me_13C_3 | 0.0162 | 0.0199 | 1.1069 | 0.0501 | 2.5914 | 1.9874 | 0.0077 | 0.0120 | 1.7597 | 0.0624 | 1.9437 | 2.1302 |
| FA_16:0_Me_13C_4 | NA | 0.0115 | 1.3377 | 0.0501 | 2.1867 | 1.5546 | NA | 0.0084 | 1.6257 | 0.0742 | 1.4355 | 1.4070 |
| FA_16:0_Me_13C_5 | NA | 0.0255 | 1.4832 | 0.0748 | 2.0127 | 1.3877 | NA | 0.0151 | 1.6643 | 0.1435 | 1.4765 | 1.4311 |
| FA_16:0_Me_13C_6 | NA | 0.0298 | 1.6991 | 0.1075 | 1.9545 | 1.3454 | NA | 0.0273 | 1.6502 | 0.1957 | 1.3879 | 1.3346 |
| FA_16:0_Me_13C_7 | NA | 0.0534 | 1.7374 | 0.1417 | 1.8330 | 1.2109 | NA | 0.0601 | 1.6763 | 0.3378 | 1.3621 | 1.3665 |
| FA_16:0_Me_13C_8 | NA | 0.0630 | 1.7739 | 0.1703 | 1.7706 | 1.1698 | NA | 0.0679 | 1.6481 | 0.4027 | 1.3680 | 1.3666 |
| FA_16:0_Me_13C_9 | NA | 0.0910 | 1.6657 | 0.2135 | 1.6355 | 1.0349 | NA | 0.1224 | 1.7047 | 0.5876 | 1.3407 | 1.4666 |
| FA_16:1_Me | 0.6674 | 1.3238 | 0.6627 | 0.5043 | 0.9986 | 0.7120 | 1.1938 | 1.3197 | 1.1695 | 1.6514 | 0.7304 | 1.2837 |
| FA_16:1_Me_13C_1 | 0.1604 | 0.2171 | 0.7784 | 3.7476 | 1.1155 | 1.1827 | 0.2474 | 1.8862 | 0.7409 | 0.7757 | 1.1940 | 1.8923 |
| FA_16:1_Me_13C_10 | NA | NA | 0.4943 | NA | 0.4874 | 1.1157 | NA | NA | 0.1681 | NA | 0.7385 | 2.9960 |
| FA_16:1_Me_13C_2 | 0.0368 | 0.0488 | 0.5923 | 0.0444 | 1.8917 | 1.6413 | 0.0715 | 0.0986 | 1.0388 | NA | 1.3911 | 1.9722 |
| FA_16:1_Me_13C_3 | NA | NA | 0.4953 | NA | 1.5511 | 1.3307 | NA | NA | 1.1319 | NA | 1.0068 | 0.8222 |
| FA_16:1_Me_13C_4 | NA | NA | 0.6470 | NA | 1.3662 | 1.1809 | NA | NA | 0.7288 | NA | 0.9977 | 1.0793 |
| FA_16:1_Me_13C_5 | NA | NA | 0.7253 | NA | 1.0983 | 1.0941 | NA | NA | 0.8193 | NA | 1.0623 | 1.2006 |
| FA_16:1_Me_13C_6 | NA | NA | 0.7225 | NA | 1.2866 | 1.0874 | NA | NA | 0.8089 | NA | 0.9464 | 1.1482 |
| FA_16:1_Me_13C_7 | NA | NA | 0.8722 | NA | 1.1646 | 0.7765 | NA | NA | 1.0614 | NA | 0.8899 | 1.2354 |
| FA_16:1_Me_13C_8 | NA | NA | 0.8126 | NA | 1.2050 | 0.9637 | NA | NA | 0.8297 | NA | 1.0239 | 1.1652 |
| FA_16:1_Me_13C_9 | NA | NA | 0.7158 | NA | 0.9844 | 0.8288 | NA | NA | 1.0644 | NA | 0.9019 | 1.5048 |
| FA_18:0_Me | 0.8309 | 1.3230 | 0.6299 | 0.7360 | 0.8498 | 0.6936 | 1.2764 | 1.3762 | 0.9540 | 1.4981 | 0.7685 | 1.2297 |
| FA_18:0_Me_13C_1 | 0.1786 | 0.4824 | 0.4363 | 0.2000 | 1.4553 | 1.6433 | 0.3900 | 0.4896 | 0.9923 | 0.5461 | 1.6951 | 3.3398 |
| FA_18:0_Me_13C_10 | NA | 0.0533 | 1.5644 | 0.1610 | 1.6638 | 1.3075 | NA | 0.0648 | 1.4409 | 0.3536 | 1.5455 | 1.6297 |
| FA_18:0_Me_13C_2 | 0.0051 | 0.0449 | 0.7789 | 0.0879 | 2.2079 | 2.1125 | 0.0037 | 0.0473 | 1.3683 | 0.1670 | 1.8711 | 2.3640 |
| FA_18:0_Me_13C_3 | 0.0138 | 0.0274 | 0.7733 | 0.0251 | 2.0950 | 2.0436 | 0.0134 | 0.0174 | 1.3466 | 0.0313 | 1.9476 | 2.3576 |
| FA_18:0_Me_13C_4 | 0.0016 | 0.0079 | 1.1539 | 0.0403 | 2.3059 | 2.1104 | 0.0005 | 0.0070 | 1.5353 | 0.0472 | 1.8284 | 1.9780 |
| FA_18:0_Me_13C_5 | NA | NA | 0.8936 | 0.0444 | 1.5467 | 1.3412 | NA | NA | 1.1228 | 0.0592 | 1.2841 | 1.3945 |
| FA_18:0_Me_13C_6 | NA | 0.0143 | 1.3778 | 0.0699 | 1.8889 | 1.6658 | NA | 0.0117 | 1.3756 | 0.0924 | 1.5625 | 1.6385 |
| FA_18:0_Me_13C_7 | NA | 0.0221 | 1.4860 | 0.1009 | 1.8085 | 1.5369 | NA | 0.0188 | 1.4381 | 0.1818 | 1.5805 | 1.5537 |
| FA_18:0_Me_13C_8 | NA | 0.0284 | 1.5473 | 0.1192 | 1.7655 | 1.4705 | NA | 0.0268 | 1.4120 | 0.1935 | 1.5447 | 1.6233 |
| FA_18:0_Me_13C_9 | NA | 0.0430 | 1.4953 | 0.1461 | 1.7265 | 1.3425 | NA | 0.0561 | 1.4412 | 0.3381 | 1.5749 | 1.6156 |
| FA_18:1_Me | 0.7740 | 1.1332 | 0.7209 | 0.7147 | 0.9342 | 0.7580 | 1.1899 | 1.2901 | 1.0896 | 1.4324 | 0.8564 | 1.2507 |
| FA_18:1_Me_13C_1 | 0.4705 | 0.9751 | 0.4599 | 0.4137 | 1.0200 | 1.0601 | 0.9627 | 1.1224 | 1.0585 | 1.3464 | 1.0898 | 2.1365 |
| FA_18:1_Me_13C_10 | NA | NA | 0.8160 | NA | 1.0425 | 1.0870 | NA | NA | 0.7311 | NA | 1.1909 | 1.1325 |
| FA_18:1_Me_13C_2 | 0.1298 | 0.1322 | 0.7626 | 0.1510 | 1.9916 | 2.1812 | 0.3370 | 0.4374 | 1.2638 | 0.5678 | 2.0584 | 1.8433 |
| FA_18:1_Me_13C_3 | 0.1506 | 0.2099 | 0.5191 | 0.2142 | 1.7330 | 2.0923 | 0.4396 | 0.2842 | 1.0007 | 0.3998 | 1.6500 | 2.9198 |
| FA_18:1_Me_13C_4 | NA | NA | 0.5119 | NA | 1.1140 | 1.4389 | NA | NA | 0.5563 | NA | 1.1452 | 1.2337 |
| FA_18:1_Me_13C_5 | NA | NA | 0.6353 | NA | 1.3511 | 1.4262 | NA | NA | 0.6611 | NA | 1.2263 | 0.7000 |
| FA_18:1_Me_13C_6 | NA | NA | 0.6994 | NA | 1.1835 | 1.3452 | NA | NA | 0.6208 | NA | 1.1825 | 0.9686 |
| FA_18:1_Me_13C_7 | NA | NA | 0.6781 | NA | 1.0491 | 1.2317 | NA | NA | 0.5077 | NA | 1.1424 | 1.3910 |
| FA_18:1_Me_13C_8 | NA | NA | 0.7654 | NA | 1.0942 | 1.2231 | NA | NA | 0.6244 | NA | 1.0921 | 1.2008 |
| FA_18:1_Me_13C_9 | NA | NA | 0.8346 | NA | 1.0455 | 1.1467 | NA | NA | 0.7564 | NA | 1.3358 | 0.8810 |
Factors:
| F1 | Cell line:pLKO | Labelint time (hours):0 |
| F2 | Cell line:pLKO | Labelint time (hours):1 |
| F3 | Cell line:pLKO | Labelint time (hours):24 |
| F4 | Cell line:pLKO | Labelint time (hours):3 |
| F5 | Cell line:pLKO | Labelint time (hours):48 |
| F6 | Cell line:pLKO | Labelint time (hours):72 |
| F7 | Cell line:shIDH1 | Labelint time (hours):0 |
| F8 | Cell line:shIDH1 | Labelint time (hours):1 |
| F9 | Cell line:shIDH1 | Labelint time (hours):24 |
| F10 | Cell line:shIDH1 | Labelint time (hours):3 |
| F11 | Cell line:shIDH1 | Labelint time (hours):48 |
| F12 | Cell line:shIDH1 | Labelint time (hours):72 |
