Data for Targeting CRBN to alter CD8 T cell metabolism (Study ST000307)

(Analysis AN000487)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
2^,4^-DIHYDROXYACETOPHENONE 1.4069 0.6538 1.5395 0.6686 0.6241 1.1070
2-HYDROXYPHENYLACETIC ACID 0.9452 0.4553 1.1470 0.3614 0.2299 2.8613
3-(2-HYDROXYPHENYL)PROPANOATE 4.9285 0.3382 0.2541 0.0806 0.2975 0.1010
3-HYDROXYPHENYLACETATE 2.2184 1.0474 1.4474 0.5010 0.3677 0.4180
3-METHYL-2-OXOVALERIC ACID 4.1264 0.3525 0.4584 0.2153 0.3794 0.4680
3-SULFINO-L-ALANINE 0.0338 3.4235 0.2654 1.1554 0.4208 0.7012
4-COUMARATE 1.8283 0.7093 0.7906 0.7294 0.7009 1.2415
4-GUANIDINOBUTANOATE 1.4636 1.4237 1.4403 0.7691 0.3832 0.5202
4-METHYL-2-OXO-PENTANOIC ACID 4.1251 0.3282 0.3498 0.3650 0.3585 0.4734
4-PYRIDOXATE 2.5004 0.4912 2.0007 0.3637 0.2740 0.3701
ADENINE 0.9552 0.7365 0.9375 0.6246 0.8692 1.8770
ALDOPENTOSE 0.1355 1.3259 0.0560 0.9491 0.1233 3.4101
ALLANTOIN 0.3687 2.2177 0.6067 1.3934 0.4743 0.7499
ALPHA-HYDROXYISOBUTYRIC ACID 3.3551 0.4663 0.5314 0.4865 0.5437 0.6170
AZELAIC ACID 1.8350 0.9329 1.6885 0.4812 0.5486 0.5138
C12H22O11-DISACCHARIDE-(6C/6C; GLC-GLC/GLC-FRC/GAL-GLC) 0.0262 1.9552 1.1616 0.7113 0.2242 1.9215
C6H12O6-HEXOSE/KETOSE/INOSITOL 0.0483 0.9454 0.0861 0.9330 0.0694 3.9179
CITRAMALATE 2.3570 1.4142 0.2071 0.5956 0.4051 1.0210
CREATINE 0.0151 2.4688 0.2883 1.2124 1.1900 0.8254
CYTIDINE 2.4703 0.6394 0.2050 0.2782 0.4419 1.9652
Disaccharide (6C/6C) 0.1610 2.2900 1.1236 0.9573 0.3368 1.1314
ETHYLMALONIC ACID 1.6454 1.0969 0.4735 0.7152 0.5446 1.5244
GLUCONIC ACID 0.3043 1.9187 0.0841 0.9577 0.2532 2.4820
GLUTARATE 1.0915 1.4861 0.5206 0.7188 0.6737 1.5094
GLYCERALDEHYDE/LACTATE 0.8674 0.9552 0.9930 0.7916 0.8575 1.5354
GLYCOLATE 0.5744 0.7389 1.5933 0.8231 0.5246 1.7456
GUANINE 0.1761 2.5931 0.3286 0.9148 0.9166 1.0709
GUANOSINE 5^-MONOPHOSPHATE 0.5533 1.4173 NA 0.1043 0.3078 1.9817
hexose alcohol 0.1995 2.6345 0.5957 1.3965 0.3055 0.8683
HOMOVANILLATE 4.5201 0.7054 0.3214 0.1703 0.2069 0.0759
HYPOXANTHINE 0.1490 1.5613 0.2653 1.0273 0.7369 2.2602
ISOCITRIC ACID 1.0243 2.2008 0.3173 2.1336 0.1802 0.1438
L-GLUTAMINE 0.5803 1.6147 0.6452 0.7410 0.5700 1.8487
L-METHIONINE 0.5994 0.6600 0.1685 0.0940 0.2549 4.2231
L-PHENYLALANINE 0.7743 1.0677 0.2844 0.3265 0.2483 3.2987
L-TYROSINE 1.4289 1.6444 0.4290 0.6501 0.3699 1.4777
MALONIC ACID 0.2257 2.5460 0.5589 1.1500 0.3739 1.1456
MEVALOLACTONE 3.7923 0.6285 0.8467 0.2698 0.1839 0.2788
N-ACETYL-DL-GLUTAMIC ACID 3.9151 0.6088 0.2928 0.2838 0.2369 0.6627
N-ACETYL-DL-SERINE 1.2290 1.7635 0.7755 0.8343 0.6612 0.7365
N-ACETYLGLYCINE 1.7136 0.9973 0.4643 0.7391 1.3643 0.7215
N-ACETYL-L-ASPARTIC ACID 1.1867 2.8533 0.1862 0.9338 0.3836 0.4563
N-ACETYL-L-LEUCINE 4.4487 0.3314 0.2999 0.2658 0.2989 0.3553
NICOTINATE 4.2821 0.2919 0.1345 0.2502 0.0756 0.9657
N-METHYL-D-ASPARTIC ACID 0.4707 0.6953 0.2249 0.6245 0.2862 3.6983
O-ACETYL-L-SERINE 1.1682 0.6732 0.2657 0.3640 0.3028 3.2262
(R)-MALATE 1.6440 1.8768 0.1303 1.0562 0.3649 0.9278
Salicylic Acid-d4 0.9870 0.9742 0.9018 0.9766 1.0344 1.1259
SUCCINATE 3.1801 0.9522 0.2817 0.5150 0.4249 0.6461
Succinic Acid-d4 0.8859 1.0344 0.9700 1.0791 0.9915 1.0391
THREONINE/HOMOSERINE 0.4796 0.9555 0.5011 0.6160 0.3833 3.0646
THYMIDINE 5^-MONOPHOSPHATE 0.0226 0.2333 0.0002 0.0014 0.0951 3.3099
URACIL 2.8052 0.3958 0.3066 0.2086 0.4546 1.8291
URATE 0.7567 2.0073 0.6887 0.9199 0.6726 0.9549
URIDINE 2.5718 0.9950 0.2394 0.3133 0.4704 1.4101
UROCANATE 1.3817 1.7653 0.7861 0.7302 0.7409 0.5958
XANTHINE 0.6044 1.0749 0.2826 0.5895 0.4922 2.9564
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Factors:

F1Strain:CRBN -/- | Treatment:anti-CD3 & anti-CD28 stimulation
F2Strain:CRBN +/+ | Treatment:anti-CD3 & anti-CD28 stimulation
F3Strain:CRBN -/- | Treatment:anti-CD3 stimulation
F4Strain:CRBN +/+ | Treatment:anti-CD3 stimulation
F5Strain:CRBN -/- | Treatment:unstimulated
F6Strain:CRBN +/+ | Treatment:unstimulated
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