Data for Metabolome of three Vancomycin-intermediate Staphylococcus aureus (VISA) mutants compared with the parent strain MM66 (Study ST000309)
(Analysis AN000489)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
11-Octadecenoic acid | 0.3443 | NA | 1.9475 | 0.7082 |
1-Methyl-beta-D-galactopyranoside | 0.9036 | 0.5784 | 0.0871 | 2.4308 |
1-Monohexadecanoylglycerol | 1.2431 | 1.2939 | 0.4905 | 0.9725 |
1-Monooctadecanoylglycerol | 1.1439 | 1.0302 | 0.7815 | 1.0444 |
2(1H)-Pyrimidinone, 1-b-D-ribofuranosyl-4-hydroxy-5^-P | 1.1027 | NA | NA | 0.8973 |
2,4,6-Tri-tert.-butylbenzenethiol | 1.2034 | 0.8595 | 0.5954 | 1.3417 |
2,4-hydroxybenzoic acid | NA | 0.3750 | 1.1531 | 1.4719 |
2,4-hydroxybutanoic acid | 0.3645 | 1.5645 | NA | 1.0710 |
2-Amino-4,6-dihydroxypyrimidine | 0.8457 | 0.9574 | NA | 1.1968 |
2-Aminoadipic acid | 0.7286 | 0.5985 | NA | 1.6729 |
2-Aminobutyric acid | NA | NA | NA | 1.0000 |
2-hydroxy-1,3-propanediylphosphate | 1.5447 | 0.3496 | NA | 1.1057 |
2-hydroxybutanoic acid | 0.7051 | 0.8333 | NA | 1.4615 |
2-hydroxyglutaric acid | 0.8061 | 0.8580 | 0.0480 | 2.2878 |
2-methyl-2,3-hydroxypropanoic acid | 1.5823 | 1.2816 | 0.1564 | 0.9797 |
2-methyl-2-hydroxybutanoic acid | 0.9320 | NA | NA | 1.0680 |
2-Methylserine | 1.1135 | 1.3129 | NA | 0.5737 |
2-oxy-3-hydroxypropylphosphate | NA | NA | NA | 1.0000 |
2-PGA | 0.9876 | 1.1328 | NA | 0.8797 |
2-Pyrrolidone-5-carboxylic acid | 0.8595 | 1.1405 | NA | NA |
3-Hydroxypyruvic acid | 0.2567 | NA | 1.7433 | NA |
3-PGA | 1.4090 | 0.7067 | 0.0211 | 1.8632 |
4,5-dimethyl-2,6-hydroxypyrimidine | 0.9906 | 0.8774 | NA | 1.1321 |
4,8-hydroxy-2-Quinolinecarboxylic acid | 0.9217 | 0.8942 | 0.6738 | 1.5103 |
4-hydroxyproline | 0.0969 | NA | 2.8500 | 0.0531 |
4-methyl-2-hydroxypentanoic acid | 1.0000 | 0.6250 | NA | 1.3750 |
5-Methylthioadenosine | 1.2795 | 1.3468 | 0.3502 | 1.0236 |
Adenine | 1.1798 | 0.7136 | 0.3404 | 1.7662 |
Adenosine | 1.2629 | 1.0984 | 0.3429 | 1.2958 |
a-Glycerophosphorylglycerol | 1.4755 | 0.2342 | NA | 1.2903 |
a-Ketoglutaric acid | 1.2178 | 1.6996 | 0.0492 | 1.0334 |
alanine | 1.3808 | 1.4568 | 0.0776 | 1.0848 |
Arabinofuranose | 1.0530 | 0.9563 | NA | 0.9907 |
Arabitol | 1.8232 | 0.1378 | 0.0712 | 1.9679 |
Asparagine | 1.1206 | 1.7325 | 0.0388 | 1.1081 |
Aspartic acid | 1.2904 | 1.1882 | 0.0669 | 1.4545 |
B-alanine | 0.5056 | 0.9258 | 0.0427 | 2.5258 |
Benzoic acid | 1.0909 | 1.1515 | 0.6465 | 1.1111 |
b-Lactic acid | 0.4275 | 0.9732 | 1.0629 | 1.5365 |
Butylamine | 0.1655 | 1.3968 | 2.1993 | 0.2384 |
Cadaverine | 1.1443 | 1.9786 | 0.1736 | 0.7034 |
Cholesterol | NA | NA | NA | 1.0000 |
Citramalic acid | NA | 0.5630 | NA | 1.4370 |
Citric acid | 1.7217 | 0.7369 | 0.0601 | 1.4812 |
Cystathonine | 1.2544 | 0.9698 | NA | 0.7758 |
cysteine | 0.3478 | NA | 1.6522 | NA |
Diethylene glycol | NA | NA | 1.0000 | NA |
Dihydroorotic acid | 1.1326 | 0.9380 | NA | 0.9294 |
Docosanoic acid | 0.8000 | 0.6897 | 0.7448 | 1.7655 |
docosanol | 0.6678 | 0.4710 | 0.5905 | 2.2707 |
Dodecanoic acid | 1.0251 | 0.6935 | 1.2814 | NA |
dodecanoylglycerol | NA | 1.3247 | 1.3377 | 0.3377 |
Eicosanoic acid | 0.9589 | 0.6108 | 0.4681 | 1.9621 |
eicosanoylglycerol | 1.2471 | 0.7373 | 0.3373 | 1.6784 |
ethanolamine | 0.8983 | 0.5163 | 1.7463 | 0.8391 |
Ethyl phosphoric acid | 0.3950 | 0.0308 | 2.0217 | 1.5524 |
fructose-6-p | 0.3774 | 0.6541 | 0.0575 | 2.9110 |
Fumaric acid | 1.2267 | 1.1480 | 0.0758 | 1.5495 |
GABA | NA | 1.2692 | 0.7308 | NA |
Galactitol | NA | NA | NA | 1.0000 |
galactosamine | 0.8684 | 1.1316 | NA | NA |
Gluconic acid | 1.3736 | 0.4366 | NA | 1.1899 |
glucosamine | 1.0403 | 1.0817 | NA | 0.8781 |
Glucose | NA | 0.1988 | 0.9669 | 1.8343 |
glucose-6-p | 0.8245 | 0.6714 | 0.0090 | 2.4952 |
glutamic acid | 1.2848 | 1.5013 | 0.0475 | 1.1664 |
Glutamine | 0.9332 | 2.2661 | 0.2228 | 0.5780 |
Glutaric acid | 0.8169 | NA | NA | 1.1831 |
Glyceric acid | 1.2150 | 1.0406 | 0.0602 | 1.6842 |
Glycerol | 1.1732 | 0.1466 | 0.0747 | 2.6055 |
Glycerol-2-P | 1.0702 | 0.6677 | 0.1780 | 2.0840 |
Glycerol-3-P | 0.8395 | 0.7601 | 0.1849 | 2.2156 |
Glycine | 0.8681 | 1.1176 | 0.1515 | 1.8627 |
Glycolic acid | 1.4789 | 1.1391 | 0.4346 | 0.9475 |
Guanine | 0.8686 | 0.9918 | 0.0494 | 2.0902 |
Guanosine | 1.0805 | 1.4457 | 0.1335 | 1.3403 |
Heptadecanoic acid | 0.7578 | 0.7753 | 0.2390 | 2.2279 |
Heptadecanoylglycerol | 1.0786 | 0.9303 | 0.2563 | 1.7348 |
Hexadecanol | NA | NA | 1.0000 | NA |
Homocysteine | 0.9044 | 1.1426 | NA | 0.9530 |
Homoserine | 1.2421 | 1.1832 | 0.0371 | 1.5376 |
Hydroxylamine | 1.0324 | 0.5877 | 1.1463 | 1.2336 |
Hydroxyphosphinyloxyacetic acid | 1.0303 | 1.6847 | 0.1628 | 1.1221 |
Hypoxanthine | 1.1053 | 1.6184 | 0.2763 | NA |
Inosine | 1.5130 | 0.4870 | NA | NA |
Inositol | 1.7968 | 0.7891 | 0.0444 | 1.3698 |
isoleucine | 1.1544 | 0.9064 | 0.2369 | 1.7023 |
lactic acid | 1.2177 | 0.6781 | 0.3150 | 1.7892 |
leucine | 1.3023 | 1.1143 | 0.1430 | 1.4404 |
lysine | 1.3593 | 1.1098 | 0.0423 | 1.4885 |
malic acid | 1.2940 | 0.5012 | NA | 1.2048 |
Malonic acid | 1.5570 | 0.7785 | 0.0380 | 1.6266 |
Mannitol | 0.2406 | 0.1429 | 0.1805 | 3.4361 |
Mannitol-p | 0.6159 | 0.6098 | NA | 1.7744 |
mannose-6-p | 0.3824 | 0.2412 | NA | 2.3765 |
methionine | 1.2675 | 1.1253 | 0.1250 | 1.4822 |
Methylcytosine | NA | NA | NA | 1.0000 |
methyl-hexadecanoic acid | 0.6359 | 0.6296 | 0.2630 | 2.4715 |
methyl-tetradecanoic acid | 0.8684 | 0.5050 | NA | 1.6265 |
Monomethylphosphate | 1.0667 | 1.2326 | 0.0506 | 1.6501 |
N-Acetyl aspartic acid | 1.1957 | 0.7993 | NA | 1.0050 |
N-Acetylglucosylamine | 1.3160 | NA | NA | 0.6840 |
N-Acetylglutamic acid | 1.1433 | 1.1205 | 0.2668 | 1.4694 |
N-Acetyl-Lysine | 1.2665 | 0.7399 | 0.4896 | 1.5040 |
N-Acetyl-serine | 0.5604 | 0.7653 | NA | 1.6743 |
Nicotinamide | 1.2579 | 1.0903 | 0.1427 | 1.5091 |
Nicotinic acid | 0.8296 | 2.1030 | 0.1427 | 0.9247 |
Nonadecanoic acid | 0.7634 | 0.7230 | 0.2149 | 2.2988 |
Nonadecanoylglycerol | 1.0405 | 0.7928 | 0.2387 | 1.9279 |
Nonanoic acid | 0.8000 | 0.7750 | 1.1625 | 1.2625 |
octadecanol | 0.8516 | 0.6968 | 1.1871 | 1.2645 |
ornitine | 1.3396 | 1.7711 | 0.0900 | 0.7994 |
Orotic acid | 0.8305 | 1.0339 | NA | 1.1356 |
Palmitelaidic acid | 2.0250 | 0.3750 | 0.8500 | 0.7500 |
palmitic acid | 1.0129 | 0.8603 | 0.9872 | 1.1395 |
Pentadecanoic acid | 0.9353 | 0.4688 | 0.2867 | 2.3092 |
Pentadecanoylglycerol | 0.5897 | 0.3890 | 0.7762 | 2.2451 |
phenylalanine | 1.3855 | 0.8383 | 0.2030 | 1.5732 |
Phosphoric acid | 1.4536 | 0.8198 | 0.0733 | 1.6533 |
Pipecolic acid | 0.7214 | 0.7302 | NA | 1.5484 |
Proline | 1.2610 | 1.4678 | 0.2573 | 1.0140 |
Propan-1,2-diol | 1.4044 | 0.8177 | 1.0789 | 0.6991 |
Putrescine | 1.1551 | 0.6032 | 0.3268 | 1.9149 |
Pyroglutamic acid | 1.3845 | 0.7354 | 0.0945 | 1.7856 |
pyrophosphate | 1.2968 | 0.7253 | 0.0173 | 1.9605 |
Pyrrole-2-carboxylic acid | NA | 0.9259 | 1.0741 | NA |
pyruvic acid | 0.9351 | 0.3681 | 0.5043 | 2.1925 |
Ribitol | 0.9846 | 0.5489 | 0.0549 | 2.4117 |
ribose | 1.3957 | 1.0102 | 0.1507 | 1.4434 |
Ribose-5-p | 1.0477 | 1.6572 | 0.0771 | 1.2180 |
serine | 0.8806 | 1.6468 | 0.1322 | 1.3405 |
Sorbitol | NA | NA | NA | 1.0000 |
Sorbitol-6-P | 2.8344 | 0.0912 | 0.0744 | NA |
Spermidine | 1.0166 | 0.7003 | 0.0230 | 2.2601 |
Squalene | 0.7067 | 0.9246 | 1.1914 | 1.1772 |
stearic acid | 0.8933 | 0.7742 | 0.9893 | 1.3432 |
Succinic acid | 1.3629 | 1.1662 | 0.0764 | 1.3945 |
sucrose | NA | NA | 0.2105 | 1.7895 |
Tetradecanoic acid | 1.0962 | 0.8185 | 1.0853 | NA |
Threonic acid | 1.2601 | 1.5895 | 0.0366 | 1.1137 |
Threonine | 1.2610 | 1.2025 | 0.1921 | 1.3445 |
Thymine | 0.7403 | 0.9386 | 0.0925 | 2.2286 |
Tryptophan | 1.1340 | 1.4606 | 0.1429 | 1.2625 |
tyrosine | 1.1032 | 1.1661 | 0.0625 | 1.6682 |
Uracil | 0.9618 | 1.3991 | 0.3354 | 1.3037 |
Urea | 1.3471 | 0.8034 | 0.9539 | 0.8956 |
Uridine | 1.0067 | 0.6578 | 0.1023 | 2.2332 |
valine | 1.2548 | 0.9653 | 0.1121 | 1.6679 |
Xylitol | 1.5808 | 1.2544 | 0.0683 | 1.0965 |
Xylulose | NA | NA | NA | 1.0000 |
Factors:
F1 | source:mutant | type:VISA2 |
F2 | source:mutant | type:VISA3 |
F3 | source:mutant | type:VISA4 |
F4 | source:parent | type:hVISA |