Data for Metabolome of three Vancomycin-intermediate Staphylococcus aureus (VISA) mutants compared with the parent strain MM66 (Study ST000309)

(Analysis AN000489)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
11-Octadecenoic acid 0.3443 NA 1.9475 0.7082
1-Methyl-beta-D-galactopyranoside 0.9036 0.5784 0.0871 2.4308
1-Monohexadecanoylglycerol 1.2431 1.2939 0.4905 0.9725
1-Monooctadecanoylglycerol 1.1439 1.0302 0.7815 1.0444
2(1H)-Pyrimidinone, 1-b-D-ribofuranosyl-4-hydroxy-5^-P 1.1027 NA NA 0.8973
2,4,6-Tri-tert.-butylbenzenethiol 1.2034 0.8595 0.5954 1.3417
2,4-hydroxybenzoic acid NA 0.3750 1.1531 1.4719
2,4-hydroxybutanoic acid 0.3645 1.5645 NA 1.0710
2-Amino-4,6-dihydroxypyrimidine 0.8457 0.9574 NA 1.1968
2-Aminoadipic acid 0.7286 0.5985 NA 1.6729
2-Aminobutyric acid NA NA NA 1.0000
2-hydroxy-1,3-propanediylphosphate 1.5447 0.3496 NA 1.1057
2-hydroxybutanoic acid 0.7051 0.8333 NA 1.4615
2-hydroxyglutaric acid 0.8061 0.8580 0.0480 2.2878
2-methyl-2,3-hydroxypropanoic acid 1.5823 1.2816 0.1564 0.9797
2-methyl-2-hydroxybutanoic acid 0.9320 NA NA 1.0680
2-Methylserine 1.1135 1.3129 NA 0.5737
2-oxy-3-hydroxypropylphosphate NA NA NA 1.0000
2-PGA 0.9876 1.1328 NA 0.8797
2-Pyrrolidone-5-carboxylic acid 0.8595 1.1405 NA NA
3-Hydroxypyruvic acid 0.2567 NA 1.7433 NA
3-PGA 1.4090 0.7067 0.0211 1.8632
4,5-dimethyl-2,6-hydroxypyrimidine 0.9906 0.8774 NA 1.1321
4,8-hydroxy-2-Quinolinecarboxylic acid 0.9217 0.8942 0.6738 1.5103
4-hydroxyproline 0.0969 NA 2.8500 0.0531
4-methyl-2-hydroxypentanoic acid 1.0000 0.6250 NA 1.3750
5-Methylthioadenosine 1.2795 1.3468 0.3502 1.0236
Adenine 1.1798 0.7136 0.3404 1.7662
Adenosine 1.2629 1.0984 0.3429 1.2958
a-Glycerophosphorylglycerol 1.4755 0.2342 NA 1.2903
a-Ketoglutaric acid 1.2178 1.6996 0.0492 1.0334
alanine 1.3808 1.4568 0.0776 1.0848
Arabinofuranose 1.0530 0.9563 NA 0.9907
Arabitol 1.8232 0.1378 0.0712 1.9679
Asparagine 1.1206 1.7325 0.0388 1.1081
Aspartic acid 1.2904 1.1882 0.0669 1.4545
B-alanine 0.5056 0.9258 0.0427 2.5258
Benzoic acid 1.0909 1.1515 0.6465 1.1111
b-Lactic acid 0.4275 0.9732 1.0629 1.5365
Butylamine 0.1655 1.3968 2.1993 0.2384
Cadaverine 1.1443 1.9786 0.1736 0.7034
Cholesterol NA NA NA 1.0000
Citramalic acid NA 0.5630 NA 1.4370
Citric acid 1.7217 0.7369 0.0601 1.4812
Cystathonine 1.2544 0.9698 NA 0.7758
cysteine 0.3478 NA 1.6522 NA
Diethylene glycol NA NA 1.0000 NA
Dihydroorotic acid 1.1326 0.9380 NA 0.9294
Docosanoic acid 0.8000 0.6897 0.7448 1.7655
docosanol 0.6678 0.4710 0.5905 2.2707
Dodecanoic acid 1.0251 0.6935 1.2814 NA
dodecanoylglycerol NA 1.3247 1.3377 0.3377
Eicosanoic acid 0.9589 0.6108 0.4681 1.9621
eicosanoylglycerol 1.2471 0.7373 0.3373 1.6784
ethanolamine 0.8983 0.5163 1.7463 0.8391
Ethyl phosphoric acid 0.3950 0.0308 2.0217 1.5524
fructose-6-p 0.3774 0.6541 0.0575 2.9110
Fumaric acid 1.2267 1.1480 0.0758 1.5495
GABA NA 1.2692 0.7308 NA
Galactitol NA NA NA 1.0000
galactosamine 0.8684 1.1316 NA NA
Gluconic acid 1.3736 0.4366 NA 1.1899
glucosamine 1.0403 1.0817 NA 0.8781
Glucose NA 0.1988 0.9669 1.8343
glucose-6-p 0.8245 0.6714 0.0090 2.4952
glutamic acid 1.2848 1.5013 0.0475 1.1664
Glutamine 0.9332 2.2661 0.2228 0.5780
Glutaric acid 0.8169 NA NA 1.1831
Glyceric acid 1.2150 1.0406 0.0602 1.6842
Glycerol 1.1732 0.1466 0.0747 2.6055
Glycerol-2-P 1.0702 0.6677 0.1780 2.0840
Glycerol-3-P 0.8395 0.7601 0.1849 2.2156
Glycine 0.8681 1.1176 0.1515 1.8627
Glycolic acid 1.4789 1.1391 0.4346 0.9475
Guanine 0.8686 0.9918 0.0494 2.0902
Guanosine 1.0805 1.4457 0.1335 1.3403
Heptadecanoic acid 0.7578 0.7753 0.2390 2.2279
Heptadecanoylglycerol 1.0786 0.9303 0.2563 1.7348
Hexadecanol NA NA 1.0000 NA
Homocysteine 0.9044 1.1426 NA 0.9530
Homoserine 1.2421 1.1832 0.0371 1.5376
Hydroxylamine 1.0324 0.5877 1.1463 1.2336
Hydroxyphosphinyloxyacetic acid 1.0303 1.6847 0.1628 1.1221
Hypoxanthine 1.1053 1.6184 0.2763 NA
Inosine 1.5130 0.4870 NA NA
Inositol 1.7968 0.7891 0.0444 1.3698
isoleucine 1.1544 0.9064 0.2369 1.7023
lactic acid 1.2177 0.6781 0.3150 1.7892
leucine 1.3023 1.1143 0.1430 1.4404
lysine 1.3593 1.1098 0.0423 1.4885
malic acid 1.2940 0.5012 NA 1.2048
Malonic acid 1.5570 0.7785 0.0380 1.6266
Mannitol 0.2406 0.1429 0.1805 3.4361
Mannitol-p 0.6159 0.6098 NA 1.7744
mannose-6-p 0.3824 0.2412 NA 2.3765
methionine 1.2675 1.1253 0.1250 1.4822
Methylcytosine NA NA NA 1.0000
methyl-hexadecanoic acid 0.6359 0.6296 0.2630 2.4715
methyl-tetradecanoic acid 0.8684 0.5050 NA 1.6265
Monomethylphosphate 1.0667 1.2326 0.0506 1.6501
N-Acetyl aspartic acid 1.1957 0.7993 NA 1.0050
N-Acetylglucosylamine 1.3160 NA NA 0.6840
N-Acetylglutamic acid 1.1433 1.1205 0.2668 1.4694
N-Acetyl-Lysine 1.2665 0.7399 0.4896 1.5040
N-Acetyl-serine 0.5604 0.7653 NA 1.6743
Nicotinamide 1.2579 1.0903 0.1427 1.5091
Nicotinic acid 0.8296 2.1030 0.1427 0.9247
Nonadecanoic acid 0.7634 0.7230 0.2149 2.2988
Nonadecanoylglycerol 1.0405 0.7928 0.2387 1.9279
Nonanoic acid 0.8000 0.7750 1.1625 1.2625
octadecanol 0.8516 0.6968 1.1871 1.2645
ornitine 1.3396 1.7711 0.0900 0.7994
Orotic acid 0.8305 1.0339 NA 1.1356
Palmitelaidic acid 2.0250 0.3750 0.8500 0.7500
palmitic acid 1.0129 0.8603 0.9872 1.1395
Pentadecanoic acid 0.9353 0.4688 0.2867 2.3092
Pentadecanoylglycerol 0.5897 0.3890 0.7762 2.2451
phenylalanine 1.3855 0.8383 0.2030 1.5732
Phosphoric acid 1.4536 0.8198 0.0733 1.6533
Pipecolic acid 0.7214 0.7302 NA 1.5484
Proline 1.2610 1.4678 0.2573 1.0140
Propan-1,2-diol 1.4044 0.8177 1.0789 0.6991
Putrescine 1.1551 0.6032 0.3268 1.9149
Pyroglutamic acid 1.3845 0.7354 0.0945 1.7856
pyrophosphate 1.2968 0.7253 0.0173 1.9605
Pyrrole-2-carboxylic acid NA 0.9259 1.0741 NA
pyruvic acid 0.9351 0.3681 0.5043 2.1925
Ribitol 0.9846 0.5489 0.0549 2.4117
ribose 1.3957 1.0102 0.1507 1.4434
Ribose-5-p 1.0477 1.6572 0.0771 1.2180
serine 0.8806 1.6468 0.1322 1.3405
Sorbitol NA NA NA 1.0000
Sorbitol-6-P 2.8344 0.0912 0.0744 NA
Spermidine 1.0166 0.7003 0.0230 2.2601
Squalene 0.7067 0.9246 1.1914 1.1772
stearic acid 0.8933 0.7742 0.9893 1.3432
Succinic acid 1.3629 1.1662 0.0764 1.3945
sucrose NA NA 0.2105 1.7895
Tetradecanoic acid 1.0962 0.8185 1.0853 NA
Threonic acid 1.2601 1.5895 0.0366 1.1137
Threonine 1.2610 1.2025 0.1921 1.3445
Thymine 0.7403 0.9386 0.0925 2.2286
Tryptophan 1.1340 1.4606 0.1429 1.2625
tyrosine 1.1032 1.1661 0.0625 1.6682
Uracil 0.9618 1.3991 0.3354 1.3037
Urea 1.3471 0.8034 0.9539 0.8956
Uridine 1.0067 0.6578 0.1023 2.2332
valine 1.2548 0.9653 0.1121 1.6679
Xylitol 1.5808 1.2544 0.0683 1.0965
Xylulose NA NA NA 1.0000
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Factors:

F1source:mutant | type:VISA2
F2source:mutant | type:VISA3
F3source:mutant | type:VISA4
F4source:parent | type:hVISA
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