Data for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)

(Analysis AN000572)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4
1-methylimidazoleacetate 0.8707 0.8557 1.1161 1.1576
1-oleoylglycerophosphocholine (18:1) 0.8680 0.7564 0.9461 1.4295
1-palmitoleoylglycerophosphocholine (16:1)* 1.1592 0.8788 1.4136 0.8665
1-palmitoylglycerophosphocholine (16:0) 0.8799 0.7828 0.9329 1.4045
1-stearoylglycerophosphocholine (18:0) 0.7513 0.7895 1.0019 1.4573
1-stearoylglycerophosphoethanolamine 0.8468 0.7862 1.0540 1.3197
2-arachidonoylglycerophosphocholine* 0.9800 0.7723 1.0426 1.2051
2-arachidonoylglycerophosphoethanolamine* 0.8391 0.8225 0.9576 1.3808
2-docosahexaenoylglycerophosphocholine* 0.7657 0.8184 1.0480 1.3686
2-docosahexaenoylglycerophosphoethanolamine* 0.8116 0.8280 0.9942 1.3662
2-docosapentaenoylglycerophosphoethanolamine* 0.9162 0.8650 0.9866 1.2222
2-linoleoylglycerophosphoethanolamine* 0.7991 1.0441 0.7837 1.3346
2-methylbutyrylcarnitine (C5) 1.0839 0.9387 1.1346 0.8429
2-oleoylglycerophosphocholine* 0.8095 0.8574 1.0346 1.3461
2-palmitoylglycerophosphocholine* 0.8830 0.7058 0.9794 1.4318
2-palmitoylglycerophosphoethanolamine* 0.8663 0.7323 1.0069 1.3443
3-dehydrocarnitine* 0.8551 0.9078 1.2561 0.9810
4-guanidinobutanoate 0.9870 1.0997 0.8333 1.0800
5-aminovalerate 1.1981 1.1178 0.8460 0.8381
5-methylthioadenosine (MTA) 1.1869 1.1657 0.8377 0.8097
acetylcarnitine 0.9374 0.9055 1.2288 0.9283
adenosine 0.2095 0.2145 0.6626 2.9134
adenosine 2^-monophosphate (2^-AMP) 1.0402 1.0515 1.0388 0.8695
adenosine 5^-monophosphate (AMP) 0.9439 0.9593 1.0397 1.0571
arginine 0.9860 0.9464 1.0381 1.0295
argininosuccinate 0.9327 0.9020 1.0945 1.0809
beta-hydroxyisovaleroylcarnitine 0.7498 0.7895 1.3307 1.1299
betaine 1.0614 1.0447 0.7942 1.0997
butyrylcarnitine 0.9084 0.9071 1.2958 0.8887
carnitine 0.7698 0.7960 1.3369 1.0974
C-glycosyltryptophan* 1.0215 1.0916 0.9152 0.9718
choline 0.8899 0.8989 1.1140 1.0972
choline phosphate 1.2878 1.2294 0.7181 0.7647
citrulline 1.1094 1.0671 0.8285 0.9949
corticosterone 0.4707 0.4975 1.4181 0.9644
creatine 0.9878 0.9873 1.0219 1.0029
creatinine 0.9701 0.9812 0.9808 1.0679
cysteine-glutathione disulfide 0.8682 0.7733 1.1915 1.1670
cytidine 1.1539 1.2179 0.7809 0.8472
cytidine 5^-diphosphocholine 1.1717 0.9603 0.9079 0.9602
cytidine-5^-diphosphoethanolamine 1.1098 1.3093 0.7962 0.7847
cytidine 5^-monophosphate (5^-CMP) 1.0832 1.2132 0.8362 0.8674
deoxycarnitine 0.9966 1.0254 0.8724 1.0897
dimethylarginine (SDMA + ADMA) 0.9163 1.1720 1.0315 0.8511
ergothioneine 1.0704 0.8517 1.0799 1.0068
gamma-glutamylglutamate 0.7997 0.7683 1.1930 1.2390
gamma-glutamylglutamine 0.9021 0.9337 1.0577 1.1065
gamma-glutamylleucine 1.1172 1.0407 1.0539 0.7883
gamma-glutamylphenylalanine 1.0751 0.9797 1.1035 0.8486
gamma-glutamylthreonine* 1.3004 1.1000 0.8046 0.6719
gamma-glutamyltyrosine 1.1004 1.0170 1.0458 0.8368
glutamate 0.9064 0.8862 1.0782 1.1292
glutamate, gamma-methyl ester 1.0333 1.1017 0.8216 1.0435
glutamine 1.0142 1.0123 0.9890 0.9844
glutathione, oxidized (GSSG) 1.0353 0.9953 0.9624 1.0069
glutathione, reduced (GSH) 0.9193 0.9640 1.0817 1.0350
glycerophosphorylcholine (GPC) 0.6451 0.6267 1.1614 1.5668
glycylleucine 1.0058 0.8188 1.1424 1.0331
guanosine 1.1766 1.2559 0.6987 0.8687
guanosine 5^- monophosphate (5^-GMP) 1.1281 1.4345 0.6338 0.7578
homocitrulline 0.7618 0.9284 1.1061 1.2037
hydroxybutyrylcarnitine* 1.2810 1.2408 1.0448 0.4334
isobutyrylcarnitine 1.0282 0.9500 1.2817 0.7402
isoleucine 1.1300 1.0446 0.9896 0.8357
isovalerylcarnitine 0.8650 0.8549 1.2179 1.0622
leucine 1.0474 0.9915 1.0645 0.8966
lysine 1.0630 1.0820 0.9310 0.9240
methionine 1.0299 0.9891 1.0075 0.9734
N1-methyladenosine 1.0213 1.1430 0.7528 1.0520
N6-acetyllysine 0.9797 0.9451 1.0025 1.0727
N6-methyladenosine 0.9284 1.0076 1.0882 0.9724
N-acetyl-aspartyl-glutamate (NAAG) 1.0805 1.0564 0.9542 0.9089
N-acetylglutamate 0.8304 0.9367 1.0951 1.1377
N-acetylglutamine 0.8303 0.8583 1.1280 1.1834
N-acetylneuraminate 1.0127 1.0636 0.9392 0.9845
N-delta-acetylornithine* 0.4735 0.3972 1.3661 1.7632
nicotinamide 0.9651 0.9781 1.0098 1.0469
nicotinamide adenine dinucleotide (NAD+) 0.9083 0.8941 0.9929 1.1341
ophthalmate 1.5029 1.3962 0.5770 0.5239
palmitoylcarnitine 0.9766 0.9104 1.0306 1.0599
pantothenate 1.0978 1.1010 0.9468 0.8545
phenylalanine 1.0398 0.9702 1.0953 0.8948
phosphopantetheine 0.9875 1.0308 0.9521 1.0383
pipecolate 1.1158 1.2433 0.7719 0.8690
pro-hydroxy-pro 1.4369 1.3819 0.5863 0.4599
proline 1.1294 1.1590 0.8924 0.8192
propionylcarnitine 0.7043 0.6978 1.4601 1.1379
pyridoxal 1.0260 0.9974 0.9055 1.0711
pyroglutamine* 0.6798 0.6715 1.1338 1.5150
riboflavin (Vitamin B2) 0.9934 0.8894 1.1228 0.9944
serylleucine 0.7841 0.7887 1.4272 1.0603
serylphenyalanine 0.8689 1.0065 1.0864 1.0095
spermidine 1.1857 1.2232 0.8009 0.7903
spermine 1.3886 1.5465 0.5249 0.5400
stachydrine 0.4817 0.5614 1.1730 1.3702
succinylcarnitine 0.8388 0.8229 1.1952 1.0248
threonine 1.3999 1.2878 0.7873 0.5250
tryptophan 1.0881 1.0314 1.0435 0.8369
tyrosine 1.1107 1.0434 0.9461 0.8999
valine 1.1926 1.0828 0.9605 0.7641
xanthine 0.9943 0.9755 1.0387 0.9915
xanthosine 0.8939 0.9782 1.0448 1.0860
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1age:P15 | genotype:Twitcher
F2age:P15 | genotype:Wild Type
F3age:P22 | genotype:Twitcher
F4age:P22 | genotype:Wild Type
  logo