Data for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)

(Analysis AN000574)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1,2-dipalmitoylglycerol 1.0199 1.0341 0.9896 0.9607
1,3-dihydroxyacetone 0.9394 0.9597 1.1230 0.9694
1,3-dipalmitoylglycerol 0.6991 1.0079 1.1240 1.1324
1,5-anhydroglucitol (1,5-AG) 0.9339 1.4084 1.0945 0.5632
1,6-anhydroglucose 0.9284 1.2786 0.8755 0.9175
1-palmitoylglycerol (1-monopalmitin) 0.9587 1.0398 0.9840 1.0175
1-stearoylglycerol (1-monostearin) 1.0483 1.0485 0.9223 0.9808
2-aminoadipate 0.4495 0.4888 1.5061 1.5556
2-aminobutyrate 1.3666 1.2637 0.2883 0.2580
2-hydroxybutyrate (AHB) 1.3741 1.2871 0.6732 0.6247
2-hydroxyglutarate 0.9693 1.0398 1.0136 0.9773
2-oleoylglycerol (2-monoolein) 1.1121 1.4086 0.9517 0.7224
2-palmitoylglycerol (2-monopalmitin) 0.9864 0.9048 1.0287 1.0778
2-pyrrolidinone 0.8489 0.8856 1.1496 1.1158
3-hydroxybutyrate (BHBA) 1.4622 1.1918 0.7893 0.5568
3-phosphoglycerate 1.0140 1.2551 0.8253 0.9056
3-phosphoserine 0.6173 0.9715 1.1773 1.2303
5,6-dihydrouracil 1.2553 1.2439 0.7354 0.7653
5-hydroxyindoleacetate 1.0524 1.1018 1.0553 0.7905
7-alpha-hydroxycholesterol 1.1544 1.1962 0.7691 0.8803
7-beta-hydroxycholesterol 1.1342 1.0767 0.8462 0.9429
adenine 1.0013 0.9603 0.9567 1.0817
alanine 0.9940 1.0282 0.9887 0.9890
allantoin 1.1392 1.2858 0.8701 0.7049
allo-threonine 1.2054 1.1248 0.8945 0.3989
alpha-tocopherol 0.6751 0.9088 1.3466 0.8616
arabinose 1.0092 1.1858 0.8235 0.9594
arabitol 0.8137 0.8206 0.9852 1.3805
ascorbate (Vitamin C) 1.0425 1.1481 0.9585 0.8510
aspartate 0.7902 0.7385 1.2188 1.2524
beta-alanine 0.9575 0.9027 1.0131 1.1267
campesterol 1.2825 1.1386 0.8290 0.7498
chiro-inositol 0.5539 0.7536 1.1715 1.1096
cholesterol 0.9163 1.0189 1.0352 1.0296
cis-vaccenate (18:1n7) 0.8487 0.8427 1.1435 1.1650
citrate 0.9158 1.2752 0.9310 0.8780
cystathionine 1.0922 1.1510 0.8863 0.8705
cysteine 0.9419 0.8544 1.1028 1.1009
cysteinylglycine 0.6262 0.7911 1.2065 1.3034
dehydroascorbate 1.0919 0.9907 0.8682 1.0492
desmosterol 1.4865 1.5178 0.4765 0.4505
dimethylglycine 1.1408 1.2027 0.6547 0.5598
erythritol 0.8424 0.9947 1.0490 1.1140
erythronate* 0.7984 0.8921 1.1161 1.1933
ethanolamine 1.1660 1.1000 0.8729 0.8612
fructose 0.8849 1.0402 0.9720 1.1029
fructose-6-phosphate 0.9398 1.3804 0.8431 0.8367
fumarate 1.0368 1.1737 0.9090 0.8806
gamma-aminobutyrate (GABA) 0.8520 0.8724 1.1174 1.1582
glucarate (saccharate) 1.1863 1.1800 0.7201 0.8786
glucose 0.7664 1.9653 0.6280 0.6403
glucose-6-phosphate (G6P) 0.9019 1.3985 0.8691 0.8305
glycerate 1.1540 1.0734 0.8241 0.9485
glycerol 0.9367 0.8844 1.0838 1.0951
glycerol 2-phosphate 0.9322 0.9341 0.9313 1.2024
glycerol 3-phosphate (G3P) 1.0122 0.9751 0.8403 1.1724
glycerophosphoethanolamine 0.4600 0.5395 1.2584 1.6846
glycine 0.9249 0.9649 1.0706 1.0395
homoserine 1.1481 1.1470 0.7250 0.9799
hypotaurine 1.1225 0.9833 1.0597 0.8345
inositol 1-phosphate (I1P) 1.0267 1.0695 0.9430 0.9608
inositol 2-phosphate (I2P) 1.0188 1.1872 0.8375 0.9565
inositol 4-phosphate 0.6441 1.8524 0.8972 1.0244
lactate 1.0322 0.9631 0.9974 1.0073
lanosterol 1.1063 1.0349 0.6056 1.2039
lathosterol 1.1124 1.1956 0.7579 0.9341
lignocerate (24:0) 0.7469 0.9028 1.2174 1.1328
malate 0.9512 0.9966 1.0397 1.0125
maltose 1.0722 1.4491 0.6830 0.7957
maltotriose 1.1475 1.5974 0.5971 0.5093
mannitol 0.9914 1.2016 0.8417 0.9445
mannose 1.0866 1.2992 0.8264 0.7877
mannose-6-phosphate 0.9268 1.3622 0.8748 0.8362
methylphosphate 0.7744 0.8603 1.1420 1.2233
myo-inositol 0.8355 0.9349 1.0738 1.1557
N-acetylglucosamine 1.0396 0.5146 1.1935 1.0393
oleamide 1.3495 1.4678 0.4796 0.7032
oleate (18:1n9) 0.8717 0.8699 1.1388 1.1197
ornithine 1.0058 1.1408 0.8788 0.9746
oxalate (ethanedioate) 1.0513 1.0786 0.9404 0.9296
palmitic amide 1.1093 1.1246 0.8410 0.9251
palmitoyl sphingomyelin 1.1199 1.1145 0.9457 0.8199
phosphate 0.9960 0.9772 1.0005 1.0263
phosphoethanolamine 1.3384 1.3524 0.6511 0.6582
phosphoglycolate 0.9086 1.2963 0.9101 0.9109
putrescine 1.0724 1.1574 1.3749 0.3953
pyrophosphate (PPi) 0.9168 0.9078 1.0587 1.1167
ribitol 0.9922 0.9792 0.9553 1.0677
ribose 0.8761 0.8909 1.1037 1.1293
ribose 5-phosphate 0.7641 0.8913 1.0936 1.2510
ribulose 0.8301 0.9689 1.1368 1.0641
ribulose/xylulose 5-phosphate 0.8018 1.0243 1.1035 1.0703
sarcosine (N-Methylglycine) 1.0126 0.9635 1.0090 1.0149
scyllo-inositol 0.8538 0.8930 1.1453 1.1079
sedoheptulose-7-phosphate 0.8439 1.3160 0.9440 0.8961
serine 1.2573 1.2363 0.8210 0.6854
sorbitol 0.8812 0.7819 1.0342 1.3027
stearamide 1.3275 1.4890 0.4989 0.6845
stearoyl sphingomyelin 0.9038 0.9808 1.0135 1.1018
taurine 1.1981 1.1919 0.8039 0.8060
trans-4-hydroxyproline 1.4722 1.4503 0.5237 0.5538
trizma acetate 1.6552 0.6514 1.2758 0.2236
UDP-galactose 1.0758 1.0999 0.8607 0.9462
uracil 1.3135 1.1586 0.7869 0.7410
urate 0.8560 0.7226 1.6240 0.7974
urea 1.0058 1.1744 1.0358 0.7841
xylonate 0.9604 1.0414 0.9377 1.0604
xylose 0.9760 0.7848 1.2405 0.9750
xylulose 0.9913 1.0372 0.9702 1.0003
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Factors:

F1age:P15 | genotype:Twitcher
F2age:P15 | genotype:Wild Type
F3age:P22 | genotype:Twitcher
F4age:P22 | genotype:Wild Type
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