Data for Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease (Study ST000352)
(Analysis AN000574)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
1,2-dipalmitoylglycerol | 1.0199 | 1.0341 | 0.9896 | 0.9607 |
1,3-dihydroxyacetone | 0.9394 | 0.9597 | 1.1230 | 0.9694 |
1,3-dipalmitoylglycerol | 0.6991 | 1.0079 | 1.1240 | 1.1324 |
1,5-anhydroglucitol (1,5-AG) | 0.9339 | 1.4084 | 1.0945 | 0.5632 |
1,6-anhydroglucose | 0.9284 | 1.2786 | 0.8755 | 0.9175 |
1-palmitoylglycerol (1-monopalmitin) | 0.9587 | 1.0398 | 0.9840 | 1.0175 |
1-stearoylglycerol (1-monostearin) | 1.0483 | 1.0485 | 0.9223 | 0.9808 |
2-aminoadipate | 0.4495 | 0.4888 | 1.5061 | 1.5556 |
2-aminobutyrate | 1.3666 | 1.2637 | 0.2883 | 0.2580 |
2-hydroxybutyrate (AHB) | 1.3741 | 1.2871 | 0.6732 | 0.6247 |
2-hydroxyglutarate | 0.9693 | 1.0398 | 1.0136 | 0.9773 |
2-oleoylglycerol (2-monoolein) | 1.1121 | 1.4086 | 0.9517 | 0.7224 |
2-palmitoylglycerol (2-monopalmitin) | 0.9864 | 0.9048 | 1.0287 | 1.0778 |
2-pyrrolidinone | 0.8489 | 0.8856 | 1.1496 | 1.1158 |
3-hydroxybutyrate (BHBA) | 1.4622 | 1.1918 | 0.7893 | 0.5568 |
3-phosphoglycerate | 1.0140 | 1.2551 | 0.8253 | 0.9056 |
3-phosphoserine | 0.6173 | 0.9715 | 1.1773 | 1.2303 |
5,6-dihydrouracil | 1.2553 | 1.2439 | 0.7354 | 0.7653 |
5-hydroxyindoleacetate | 1.0524 | 1.1018 | 1.0553 | 0.7905 |
7-alpha-hydroxycholesterol | 1.1544 | 1.1962 | 0.7691 | 0.8803 |
7-beta-hydroxycholesterol | 1.1342 | 1.0767 | 0.8462 | 0.9429 |
adenine | 1.0013 | 0.9603 | 0.9567 | 1.0817 |
alanine | 0.9940 | 1.0282 | 0.9887 | 0.9890 |
allantoin | 1.1392 | 1.2858 | 0.8701 | 0.7049 |
allo-threonine | 1.2054 | 1.1248 | 0.8945 | 0.3989 |
alpha-tocopherol | 0.6751 | 0.9088 | 1.3466 | 0.8616 |
arabinose | 1.0092 | 1.1858 | 0.8235 | 0.9594 |
arabitol | 0.8137 | 0.8206 | 0.9852 | 1.3805 |
ascorbate (Vitamin C) | 1.0425 | 1.1481 | 0.9585 | 0.8510 |
aspartate | 0.7902 | 0.7385 | 1.2188 | 1.2524 |
beta-alanine | 0.9575 | 0.9027 | 1.0131 | 1.1267 |
campesterol | 1.2825 | 1.1386 | 0.8290 | 0.7498 |
chiro-inositol | 0.5539 | 0.7536 | 1.1715 | 1.1096 |
cholesterol | 0.9163 | 1.0189 | 1.0352 | 1.0296 |
cis-vaccenate (18:1n7) | 0.8487 | 0.8427 | 1.1435 | 1.1650 |
citrate | 0.9158 | 1.2752 | 0.9310 | 0.8780 |
cystathionine | 1.0922 | 1.1510 | 0.8863 | 0.8705 |
cysteine | 0.9419 | 0.8544 | 1.1028 | 1.1009 |
cysteinylglycine | 0.6262 | 0.7911 | 1.2065 | 1.3034 |
dehydroascorbate | 1.0919 | 0.9907 | 0.8682 | 1.0492 |
desmosterol | 1.4865 | 1.5178 | 0.4765 | 0.4505 |
dimethylglycine | 1.1408 | 1.2027 | 0.6547 | 0.5598 |
erythritol | 0.8424 | 0.9947 | 1.0490 | 1.1140 |
erythronate* | 0.7984 | 0.8921 | 1.1161 | 1.1933 |
ethanolamine | 1.1660 | 1.1000 | 0.8729 | 0.8612 |
fructose | 0.8849 | 1.0402 | 0.9720 | 1.1029 |
fructose-6-phosphate | 0.9398 | 1.3804 | 0.8431 | 0.8367 |
fumarate | 1.0368 | 1.1737 | 0.9090 | 0.8806 |
gamma-aminobutyrate (GABA) | 0.8520 | 0.8724 | 1.1174 | 1.1582 |
glucarate (saccharate) | 1.1863 | 1.1800 | 0.7201 | 0.8786 |
glucose | 0.7664 | 1.9653 | 0.6280 | 0.6403 |
glucose-6-phosphate (G6P) | 0.9019 | 1.3985 | 0.8691 | 0.8305 |
glycerate | 1.1540 | 1.0734 | 0.8241 | 0.9485 |
glycerol | 0.9367 | 0.8844 | 1.0838 | 1.0951 |
glycerol 2-phosphate | 0.9322 | 0.9341 | 0.9313 | 1.2024 |
glycerol 3-phosphate (G3P) | 1.0122 | 0.9751 | 0.8403 | 1.1724 |
glycerophosphoethanolamine | 0.4600 | 0.5395 | 1.2584 | 1.6846 |
glycine | 0.9249 | 0.9649 | 1.0706 | 1.0395 |
homoserine | 1.1481 | 1.1470 | 0.7250 | 0.9799 |
hypotaurine | 1.1225 | 0.9833 | 1.0597 | 0.8345 |
inositol 1-phosphate (I1P) | 1.0267 | 1.0695 | 0.9430 | 0.9608 |
inositol 2-phosphate (I2P) | 1.0188 | 1.1872 | 0.8375 | 0.9565 |
inositol 4-phosphate | 0.6441 | 1.8524 | 0.8972 | 1.0244 |
lactate | 1.0322 | 0.9631 | 0.9974 | 1.0073 |
lanosterol | 1.1063 | 1.0349 | 0.6056 | 1.2039 |
lathosterol | 1.1124 | 1.1956 | 0.7579 | 0.9341 |
lignocerate (24:0) | 0.7469 | 0.9028 | 1.2174 | 1.1328 |
malate | 0.9512 | 0.9966 | 1.0397 | 1.0125 |
maltose | 1.0722 | 1.4491 | 0.6830 | 0.7957 |
maltotriose | 1.1475 | 1.5974 | 0.5971 | 0.5093 |
mannitol | 0.9914 | 1.2016 | 0.8417 | 0.9445 |
mannose | 1.0866 | 1.2992 | 0.8264 | 0.7877 |
mannose-6-phosphate | 0.9268 | 1.3622 | 0.8748 | 0.8362 |
methylphosphate | 0.7744 | 0.8603 | 1.1420 | 1.2233 |
myo-inositol | 0.8355 | 0.9349 | 1.0738 | 1.1557 |
N-acetylglucosamine | 1.0396 | 0.5146 | 1.1935 | 1.0393 |
oleamide | 1.3495 | 1.4678 | 0.4796 | 0.7032 |
oleate (18:1n9) | 0.8717 | 0.8699 | 1.1388 | 1.1197 |
ornithine | 1.0058 | 1.1408 | 0.8788 | 0.9746 |
oxalate (ethanedioate) | 1.0513 | 1.0786 | 0.9404 | 0.9296 |
palmitic amide | 1.1093 | 1.1246 | 0.8410 | 0.9251 |
palmitoyl sphingomyelin | 1.1199 | 1.1145 | 0.9457 | 0.8199 |
phosphate | 0.9960 | 0.9772 | 1.0005 | 1.0263 |
phosphoethanolamine | 1.3384 | 1.3524 | 0.6511 | 0.6582 |
phosphoglycolate | 0.9086 | 1.2963 | 0.9101 | 0.9109 |
putrescine | 1.0724 | 1.1574 | 1.3749 | 0.3953 |
pyrophosphate (PPi) | 0.9168 | 0.9078 | 1.0587 | 1.1167 |
ribitol | 0.9922 | 0.9792 | 0.9553 | 1.0677 |
ribose | 0.8761 | 0.8909 | 1.1037 | 1.1293 |
ribose 5-phosphate | 0.7641 | 0.8913 | 1.0936 | 1.2510 |
ribulose | 0.8301 | 0.9689 | 1.1368 | 1.0641 |
ribulose/xylulose 5-phosphate | 0.8018 | 1.0243 | 1.1035 | 1.0703 |
sarcosine (N-Methylglycine) | 1.0126 | 0.9635 | 1.0090 | 1.0149 |
scyllo-inositol | 0.8538 | 0.8930 | 1.1453 | 1.1079 |
sedoheptulose-7-phosphate | 0.8439 | 1.3160 | 0.9440 | 0.8961 |
serine | 1.2573 | 1.2363 | 0.8210 | 0.6854 |
sorbitol | 0.8812 | 0.7819 | 1.0342 | 1.3027 |
stearamide | 1.3275 | 1.4890 | 0.4989 | 0.6845 |
stearoyl sphingomyelin | 0.9038 | 0.9808 | 1.0135 | 1.1018 |
taurine | 1.1981 | 1.1919 | 0.8039 | 0.8060 |
trans-4-hydroxyproline | 1.4722 | 1.4503 | 0.5237 | 0.5538 |
trizma acetate | 1.6552 | 0.6514 | 1.2758 | 0.2236 |
UDP-galactose | 1.0758 | 1.0999 | 0.8607 | 0.9462 |
uracil | 1.3135 | 1.1586 | 0.7869 | 0.7410 |
urate | 0.8560 | 0.7226 | 1.6240 | 0.7974 |
urea | 1.0058 | 1.1744 | 1.0358 | 0.7841 |
xylonate | 0.9604 | 1.0414 | 0.9377 | 1.0604 |
xylose | 0.9760 | 0.7848 | 1.2405 | 0.9750 |
xylulose | 0.9913 | 1.0372 | 0.9702 | 1.0003 |
Factors:
F1 | age:P15 | genotype:Twitcher |
F2 | age:P15 | genotype:Wild Type |
F3 | age:P22 | genotype:Twitcher |
F4 | age:P22 | genotype:Wild Type |