Data for Long-Chain Fatty Acid Combustion Rate Is Associated with Unique Metabolite Profiles in Skeletal Muscle Mitochondria (Study ST000393)

(Analysis AN000629)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10F11F12
1-hexadecanol 1.0126 0.8982 0.9436 0.6540 0.7040 0.7301 1.0934 1.4646 1.4404 1.0931 1.0773 0.9932
1-monoolein 0.9171 1.1831 1.0043 0.9269 1.6324 1.5653 1.4155 0.7332 0.8210 0.5520 0.6542 0.3020
1-monostearin 1.6243 1.9605 1.9855 1.3445 1.7635 1.6372 0.2259 0.1866 0.2125 0.2008 0.2205 0.0873
2-hydroxyvaleric acid 0.8517 1.3851 1.4930 0.8445 1.2624 0.9756 0.7643 0.7398 0.8993 1.0286 0.9133 0.7474
2-ketoisocaproic acid 0.6994 0.6600 0.8387 0.7591 1.0661 1.2443 0.8164 0.9798 1.2460 1.0978 1.4723 1.2541
2-monopalmitin 0.8923 1.4899 0.8457 1.0825 2.3574 1.7808 1.3319 0.3160 0.6138 0.2539 0.2923 0.2646
3-hydroxybutanoic acid 0.4650 0.6346 1.0081 0.4741 0.9793 1.3861 0.6242 0.6364 2.9919 0.7210 1.4551 0.5117
3-hydroxypyridine 0.7829 0.8267 0.9252 1.4319 0.7927 0.7210 0.5071 0.9463 0.6486 1.5525 1.7057 1.4321
adenine 0.7355 0.7426 1.0692 0.5554 0.8073 0.8522 1.4911 1.4210 1.8149 0.6581 1.1101 0.7291
adenosine-5-monophosphate 0.0684 0.0781 0.2409 0.0496 0.0488 0.0437 1.7292 1.4855 1.6707 1.3373 4.2815 1.7806
adipic acid 0.8522 0.7529 0.7281 1.7262 0.7409 0.7715 0.6310 3.0131 0.8650 0.7547 0.5821 0.7687
aspartic acid 0.1050 0.1055 0.1051 0.1074 0.0723 0.0890 4.3792 3.6974 2.3397 0.2772 0.3954 0.4662
benzoic acid 1.1286 1.1421 1.1911 1.1562 1.5695 1.2599 0.6463 0.7615 0.9187 0.6221 0.7490 0.6527
capric acid 1.0569 0.9565 1.1782 0.7325 1.0167 1.3100 0.8599 1.0382 1.3582 0.6708 0.8591 0.8691
creatinine 0.3811 0.4712 0.4490 0.7423 1.4868 0.9215 2.2831 2.0239 2.3131 0.2271 0.2515 0.2398
fructose 1 0.9880 0.9042 1.5048 1.0437 0.7373 0.6540 0.9019 1.8459 1.0884 0.6570 0.8111 0.8992
fructose 2 1.1911 1.1688 1.6261 0.7707 0.6816 0.7650 0.8004 1.9303 1.2420 0.6766 0.4801 0.6183
fumarate 1.3816 2.1583 2.8525 0.6393 1.0594 1.0823 0.2499 0.3393 0.5415 0.3412 0.5051 0.4566
GABA 0.6839 0.7876 0.8246 0.8525 0.9730 0.9920 1.5432 1.4620 1.5747 0.6836 0.8291 0.7476
glucose 1 0.3107 0.1622 0.2268 0.6076 0.1370 0.1336 2.6005 3.2143 2.8939 0.6518 0.6142 0.6329
glucose non-meox 1.4276 0.3844 0.8655 4.1839 0.3014 0.9047 0.4635 0.4652 1.1573 0.4791 0.4926 0.5370
glycerol 0.4997 0.4318 0.5938 0.4432 0.5784 0.5586 1.5302 1.8079 2.0487 1.1092 1.3304 1.3311
glycerol-alpha-phosphate 0.4624 0.3176 0.6754 0.8777 0.6863 0.7597 1.4424 2.0163 1.3145 1.2264 1.7994 0.7147
glycine 0.5648 0.4969 0.5582 0.8284 0.6152 0.3935 1.6275 1.7286 1.8079 0.8668 1.3165 1.4172
glycolic acid 1.1960 0.9137 1.3893 1.5811 1.0435 1.6092 0.6880 0.8277 0.8581 0.5046 0.6053 0.5277
heptadecanoic acid 1.1982 1.3018 1.3654 0.9384 1.1321 1.2033 0.6862 0.9297 0.9212 0.7324 0.8599 0.5820
hydroxylamine 0.8421 0.8038 1.1195 0.8964 0.9126 1.0155 0.7900 0.7807 0.8856 1.0097 1.5998 1.4912
hypoxanthine 0.1719 0.0728 0.3249 0.1991 0.2282 0.3917 2.0049 1.5171 3.2472 1.1660 1.4217 1.5264
inosine 0.2311 0.2530 0.2139 0.0848 0.7232 0.1236 2.1950 1.1700 2.5522 1.0151 2.3751 1.3877
inositol myo- 0.2119 0.2192 0.2034 0.1812 0.1852 0.4044 2.8232 2.9089 3.1732 0.5907 0.6698 0.5483
lactic acid 1.0930 1.0232 1.0182 0.9242 1.2108 1.0985 0.8656 1.3624 0.7190 0.4552 1.3130 0.9264
lauric acid 0.9647 0.8940 1.2339 0.7904 0.9789 1.8819 0.7229 0.8938 1.3275 0.5961 0.7487 0.8082
linoleic acid 0.9963 0.9358 1.3011 0.9693 1.2972 1.7755 0.8291 0.7533 1.4156 0.3074 0.5857 0.5296
lysine 0.0692 0.0450 0.0677 0.0892 0.0597 0.0825 3.3525 2.5655 3.5364 0.6519 0.9319 0.6880
malate 1.7192 2.7999 3.2166 0.0555 0.3031 0.5830 0.1778 0.2806 1.0521 0.1018 0.4944 0.8346
methionine 0.2033 0.1358 0.2572 0.3560 0.2600 0.2124 3.3360 1.9129 2.5422 1.0418 1.0567 0.8251
monopalmitin-1-glyceride 1.3366 1.4461 1.7839 1.2102 1.5262 1.5530 0.7336 0.4897 0.5277 0.4173 0.4230 0.1293
myristic acid 1.0475 1.0508 1.2372 0.7720 1.0064 2.0123 0.7475 0.8184 1.1336 0.5894 0.6832 0.7002
nicotinic acid 1.2541 0.9883 1.1976 1.5881 0.6964 0.8057 0.5784 0.6963 0.7796 1.0845 1.2912 1.0621
octadecanol 1.3187 1.1953 1.3074 0.8678 1.0768 1.1042 0.7718 1.0311 0.9600 0.8186 0.7573 0.6707
oleic acid 1.1150 1.1459 1.4055 0.8993 1.3878 1.6973 0.8350 0.7181 1.1882 0.2632 0.5401 0.4697
oxalic acid 0.9870 0.2606 0.4764 1.2514 0.2705 0.2815 1.0646 1.3929 2.3765 1.3047 1.2664 1.2737
oxoproline 0.5527 0.5112 0.5241 0.6169 0.3016 0.4500 2.2311 2.0690 2.1508 0.9151 1.1398 0.6700
palmitic acid 1.2960 2.3641 3.1460 0.6271 0.9305 0.8466 0.3983 0.4865 0.5198 0.2777 0.3860 0.2956
palmitoleic acid 0.9773 0.9226 1.1634 0.8388 1.1702 1.5964 0.8313 0.8892 1.3906 0.3438 0.8025 0.8959
pelargonic acid 1.4070 1.5997 1.3342 1.1883 1.2946 1.1746 0.6808 0.6504 0.6334 0.4819 0.7692 0.5236
pentadecanoic acid 1.2433 1.1844 1.2442 0.8558 0.9293 1.0542 0.8998 0.9106 1.2138 0.8117 0.7514 0.7764
phenylalanine 0.1419 0.0798 0.1345 0.2887 0.2200 0.1884 2.7285 1.7387 3.3713 0.8722 1.4070 0.9984
phenylalanine TMS1x 0.2110 0.1161 0.1961 0.1752 0.2241 0.2667 1.7148 1.8924 2.4986 1.5374 2.1271 1.5600
phosphoethanolamine 1.0094 0.6554 1.8198 0.8150 0.7273 1.4754 1.4887 0.7590 1.5604 0.4490 0.6044 0.3260
phosphoric acid 0.2729 0.2980 0.3486 0.1387 0.1826 0.1647 1.9955 2.0040 2.0224 1.6626 1.6507 1.7745
phthalic acid 1.2088 0.9558 1.6346 1.0973 0.9685 1.3798 0.8318 0.8895 1.1197 0.5190 0.6542 0.5016
putrescine 3TMS 0.8764 0.8499 0.9734 0.8809 0.6875 0.7278 0.7623 0.9048 0.9440 1.2098 1.6235 1.8193
ribose 0.1425 0.1169 0.1626 0.1271 0.1322 0.1510 1.6908 1.6978 2.5472 2.1284 1.6617 2.0276
ribose-5-phosphate 0.0524 0.0490 0.0551 0.0581 0.0330 0.0501 3.3862 2.5924 3.1101 1.2695 0.9022 0.6831
ribulose-5-phosphate 0.0537 0.0442 0.0471 0.0604 0.0310 0.0404 3.2862 2.1757 2.8236 1.0463 1.5790 1.1351
sorbitol 0.2962 0.6963 0.6211 1.1666 0.9413 0.2647 0.2536 7.4433 0.2768 0.1468 0.2175 0.3723
stearic acid 1.1052 1.4286 1.0929 0.9138 1.0680 1.1090 0.8284 0.9986 1.0971 0.6402 1.0524 0.5371
succinic acid 0.7380 0.8797 1.2721 0.9933 1.2279 1.5937 0.6016 0.8513 1.4796 0.4706 1.0640 0.6711
sucrose 0.8587 1.1039 1.1287 0.4503 0.7818 0.9520 0.8776 1.5784 1.9680 0.7288 0.9322 0.6153
taurine 0.0038 0.0489 0.0050 0.1146 0.0095 0.0509 3.0447 4.0501 4.6634 0.0087 0.0087 0.0037
threonine 0.3291 0.2425 0.3117 0.3763 0.3331 0.2838 2.5488 1.9128 2.0643 1.3385 1.4812 1.0801
trehalose 0.4304 0.5396 0.5345 0.4511 0.3733 0.4470 1.8327 2.0521 1.7450 1.3521 1.4048 1.1665
tris(ethylenglycol) NIST 1.4114 1.3430 1.4665 1.1486 1.2955 1.3515 0.5344 0.5996 0.6508 0.5733 0.7738 0.6112
tryptophan 0.2520 0.1420 0.2839 0.3084 0.2957 0.3377 2.3825 1.8292 3.1452 0.7988 1.5297 0.8655
tyrosine 0.1289 0.0739 0.1360 0.1320 0.1069 0.1370 2.7646 1.7891 3.5163 0.7638 1.7469 0.9055
tyrosine minor 0.1105 0.0747 0.1336 0.1105 0.1313 0.1245 1.4545 2.7930 2.0289 2.6001 1.1411 2.0635
xanthine 0.1078 0.0628 0.1328 0.1275 0.1008 0.1735 2.1846 2.3033 2.8282 1.2783 1.7685 1.3882
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Factors:

F1Organ:cytosol | Time:0 min | Dose:palmitic acid 2.4 uM
F2Organ:cytosol | Time:0 min | Dose:palmitic acid 9.6 uM
F3Organ:cytosol | Time:0 min | Dose:palmitoyl carnitine 9.6 uM
F4Organ:cytosol | Time:20 min | Dose:palmitic acid 2.4 uM
F5Organ:cytosol | Time:20 min | Dose:palmitic acid 9.6 uM
F6Organ:cytosol | Time:20 min | Dose:palmitoyl carnitine 9.6 uM
F7Organ:mitochondria | Time:0 min | Dose:palmitic acid 2.4 uM
F8Organ:mitochondria | Time:0 min | Dose:palmitic acid 9.6 uM
F9Organ:mitochondria | Time:0 min | Dose:palmitoyl carnitine 9.6 uM
F10Organ:mitochondria | Time:20 min | Dose:palmitic acid 2.4 uM
F11Organ:mitochondria | Time:20 min | Dose:palmitic acid 9.6 uM
F12Organ:mitochondria | Time:20 min | Dose:palmitoyl carnitine 9.6 uM
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