Data for Uniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response (Study ST000465)

(Analysis AN000727)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1-Methyladenosine 1.3250 1.0540 0.9397 0.6813
1-Methylhistamine NA NA NA NA
1-Methylhistidine 1.4097 0.7981 1.0406 0.7516
1-Methylnicotinamide NA NA NA NA
1-Pyrroline-5-carboxylic acid 1.3599 0.8239 1.0330 0.7831
24,25-Dihydrolanosterol 1.2176 0.7473 1.3620 0.6732
24,25-Epoxycholesterol 1.1724 0.7583 1.3178 0.7515
2-Arachidonylglycerol 0.8133 0.8146 1.6098 0.7624
2-Deoxyguanosine 5-monophosphate NA NA NA NA
2-Octenoylcarnitine NA NA NA NA
3,3^,5^-Triiodothyronine 1.1815 1.1329 0.7570 0.9286
3, 5-Tetradecadiencarnitine 1.1968 1.0021 1.1715 0.6297
3-Hydroxyanthranilic acid 0.4316 0.3665 1.7265 1.4754
3-Hydroxy-cis-5-tetradecenoylcarnitine 0.7895 1.0082 1.7880 0.4143
3-Hydroxydodecanoylcarnitine 1.5726 0.8169 0.7586 0.8519
3-Hydroxyhexadecanoylcarnitine 1.0655 0.6619 1.5238 0.7488
3-Hydroxyhexadecenoylcarnitine 0.4762 1.0378 2.2314 0.2546
3-Hydroxyhexanoylcarnitine NA NA NA NA
3-Hydroxyiso-/butyrylcarnitine 1.5118 0.7407 0.6878 1.0597
3-Hydroxyisovaleryl Carnitine 1.5546 0.7916 0.7679 0.8858
3-Hydroxylinoleylcarnitine 1.0099 0.8560 1.2760 0.8582
3-Hydroxyoleoylcarnitine 0.4233 1.0340 2.2987 0.2439
5,6-trans-25-Hydroxyvitamin D3 1.4384 0.7686 0.9559 0.8372
5alpha-Cholestanol NA NA NA NA
5-Methylthioadenosine NA NA NA NA
7a-Hydroxycholesterol 1.3782 0.8213 1.1458 0.6548
7-Dehydrocholesterol 1.5235 0.6894 1.0313 0.7558
7-ketocholesterol 1.5932 0.6837 0.8798 0.8433
7-Methylguanosine 0.9574 0.8809 1.3465 0.8152
9-Decenoylcarnitine 1.1508 0.8936 1.1140 0.8416
9-Hexadecenoylcarnitine 0.6114 1.1370 1.9901 0.2615
Acetylcholine 1.4737 0.8921 0.8134 0.8207
Adenine NA NA NA NA
Adenosine 0.2300 0.7629 2.0967 0.9104
Adenosine monophosphate 0.5840 0.2406 1.5375 1.6380
Adenosine triphosphate NA NA NA NA
Adipoylcarnitine 1.1700 0.7077 1.1181 1.0041
Agmatine NA NA NA NA
Alanine 0.9578 0.8891 1.2200 0.9331
Alpha-Tocopherol 1.3771 0.7285 1.0034 0.8910
Amphetamine 1.0791 0.8423 1.3946 0.6840
Anandamide NA NA NA NA
Anserine NA NA NA NA
Arachidonyl carnitine 1.1416 0.7600 1.0614 1.0370
B-Carotene 1.2732 0.7489 1.2179 0.7601
beta-Alanine 1.4148 1.0172 0.7373 0.8306
Betaine 1.2363 0.7958 1.1089 0.8591
Betaine aldehyde NA NA NA NA
Bilirubin NA NA NA NA
Biotin 1.0791 0.8074 0.9737 1.1398
BMP(16:0/16:0) NA NA NA NA
BMP(18:1/16:0) NA NA NA NA
BMP(18:1/16:1) NA NA NA NA
BMP(18:1/18:0) NA NA NA NA
BMP(18:1/18:1) NA NA NA NA
BMP(18:1/18:2) NA NA NA NA
BMP(18:1/20:4) NA NA NA NA
BMP(18:1/22:5) NA NA NA NA
BMP(18:1/22:6) NA NA NA NA
BMP(20:4/22:6) NA NA NA NA
BMP(22:5/22:6) NA NA NA NA
BMP(22:6/22:6) NA NA NA NA
Butyrylcarnitine 1.3664 0.8777 0.9393 0.8165
Carnosine 1.1329 0.8359 1.1017 0.9294
Ceramide(d18:1/12:0) NA NA NA NA
Ceramide(d18:1/16:0) 0.8972 1.3941 1.0016 0.7070
Ceramide(d18:1/16:0 OH) 1.4565 0.7546 1.0021 0.7868
Ceramide(d18:1/16:1) 1.4118 0.5958 1.2882 0.7042
Ceramide(d18:1/16:1 OH) 0.8662 1.4711 0.9233 0.7393
Ceramide(d18:1/16:2) NA NA NA NA
Ceramide(d18:1/16:2 OH) NA NA NA NA
Ceramide(d18:1/18:0) 0.3557 1.9328 0.6348 1.0766
Ceramide(d18:1/18:0 OH) 1.6233 0.5526 1.0339 0.7902
Ceramide(d18:1/18:1) 1.5478 0.6958 1.1340 0.6224
Ceramide(d18:1/18:1 OH) NA NA NA NA
Ceramide(d18:1/18:2) NA NA NA NA
Ceramide(d18:1/18:2 OH) NA NA NA NA
Ceramide(d18:1/20:0) NA NA NA NA
Ceramide(d18:1/20:0 OH) NA NA NA NA
Ceramide(d18:1/20:1) NA NA NA NA
Ceramide(d18:1/20:1 OH) NA NA NA NA
Ceramide(d18:1/20:2) NA NA NA NA
Ceramide(d18:1/20:2 OH) NA NA NA NA
Ceramide(d18:1/22:0) NA NA 0.9548 1.0452
Ceramide(d18:1/22:0 OH) NA NA NA NA
Ceramide(d18:1/22:1) NA NA NA NA
Ceramide(d18:1/22:2) NA NA NA NA
Ceramide(d18:1/22:2 OH) NA NA NA NA
Ceramide(d18:1/23:0) or Ceramide(d18:1/22:1 OH) NA NA NA NA
Ceramide(d18:1/24:0) NA NA NA NA
Ceramide(d18:1/24:0 OH) 0.1940 2.1137 0.9486 0.7436
Ceramide(d18:1/24:1) 0.2074 1.9807 1.1019 0.7100
Ceramide(d18:1/24:2) NA NA NA NA
Ceramide(d18:1/24:2 OH) NA NA NA NA
Ceramide(d18:1/25:0) 0.1461 2.6534 0.4955 0.7050
Ceramide(d18:1/26:0) NA NA NA NA
Ceramide(d18:1/26:0 OH) NA NA NA NA
Ceramide(d18:1/26:1) NA NA NA NA
Ceramide(d18:1/26:1 OH) NA NA NA NA
Ceramide(d18:1/26:2) NA NA NA NA
Ceramide(d18:1/26:2 OH) NA NA NA NA
Cholesterol 0.3707 1.5089 0.7077 1.4127
Choline 1.2339 0.8071 1.1006 0.8585
Cobalamin 1.2980 0.6853 1.2136 0.8031
Coenzyme Q10 NA NA NA NA
Coenzyme Q9 NA NA NA NA
CoQ10H2 NA NA NA NA
CoQ9H2 NA NA NA NA
Corticosterone 1.1622 0.9064 1.2691 0.6623
Cortisone 1.4117 1.0973 0.7653 0.7257
Creatinine 1.3211 0.9555 0.9902 0.7332
Cyanocobalamin 1.2110 0.8557 1.0747 0.8586
Cysteamine NA NA NA NA
Cysteine 1.1714 1.0242 1.0745 0.7299
Cysteineglutathione disulfide NA NA NA NA
Cytidine 0.4013 2.4437 0.9892 0.1658
Cytidine monophosphate 0.9914 1.1775 1.0611 0.7701
Cytosine 1.7875 0.8002 0.7311 0.6812
Decanoylcarnitine 1.0327 0.7167 1.6666 0.5840
Dehydroepiandrosterone NA NA NA NA
Deoxyadenosine NA NA NA NA
Deoxyadenosine monophosphate 1.4182 0.7912 0.7482 1.0424
Deoxycytidine monophosphate 1.9992 0.8211 0.6490 0.5308
Deoxyinosine monophosphate 0.8399 0.6624 1.2293 1.2684
Deoxyuridine monophosphate NA NA NA NA
Desmosterol 1.3349 0.7370 1.0580 0.8701
DHC(18:1/16:0) 1.1656 0.8505 1.3207 0.6632
DHC(18:1/22:0) NA NA NA NA
DHC(18:1/24:0) NA NA NA NA
DHC(18:1/24:1) NA NA NA NA
Dimethylglycine 1.3106 0.8165 1.0416 0.8313
Dimethyl-L-arginine 1.4626 0.8257 0.9364 0.7753
Dodecanoylcarnitine 1.0382 0.7909 1.6110 0.5599
Dodecenoylcarnitine 1.0325 0.8028 1.4065 0.7583
Dopamine 0.9461 1.0035 1.4413 0.6090
Epicatechin NA NA NA NA
Epinephrine NA NA NA NA
Ergosterol 0.9318 1.0809 1.1446 0.8427
Estradiol NA NA NA NA
Estriol NA NA NA NA
Estrone NA NA NA NA
Ethanolamine NA NA NA NA
FMN NA NA NA NA
Gamma-glutamyl-Alanine NA NA NA NA
Gamma-glutamyl-Cysteine NA NA NA NA
Gamma-glutamyl-Isoleucine 0.8291 0.6592 1.8598 0.6520
Gamma-glutamyl-Valine NA NA NA NA
GC(18:1/16:0) 0.2626 1.5199 1.9401 0.2774
GC(18:1/20:0) 0.0677 2.6307 1.0040 0.2976
GC(18:1/22:0) 0.0211 2.8740 0.7499 0.3550
GC(18:1/24:0) NA NA NA NA
GC(18:1/24:1) 0.0577 2.5250 1.0794 0.3379
Gluconolactone 1.4022 1.0428 1.0375 0.5175
Glucosamine NA NA NA NA
Glyceraldehyde 1.2638 0.8465 1.1765 0.7132
Glycerophosphocholine 0.9049 1.1786 1.3784 0.5382
Glycine 0.9942 0.9248 1.4141 0.6670
Guanosine NA NA NA NA
Guanosine monophosphate 0.6885 0.8443 0.9749 1.4923
Hexanoylcarnitine NA NA NA NA
Histamine 1.6882 0.9001 0.7557 0.6559
Homocysteine NA NA NA NA
Hydroxycholesterol Species 1.5175 0.6295 1.2741 0.5789
Hydroxykynurenine NA NA NA NA
Hydroxyproline 1.3148 0.7973 1.0624 0.8255
Hypoxanthine 0.8460 1.0969 1.5560 0.5010
Indole 1.1579 0.9130 1.2629 0.6662
Indoleacrylic acid NA NA NA NA
Isovalerylcarnitine 1.3599 0.8820 0.9409 0.8172
L-Acetylcarnitine 1.4243 0.7705 0.7638 1.0413
Lanosterin 1.8464 0.5891 0.9184 0.6461
L-Asparagine 1.2995 0.8149 1.1871 0.6985
Lathosterol 1.1719 0.7315 1.5032 0.5934
L-Carnitine 1.6084 0.7261 0.7824 0.8831
L-Cystathionine 1.3491 0.7970 0.8781 0.9759
L-Glutamine 1.1392 0.8431 1.2074 0.8103
L-Glutarylcarnitine NA NA NA NA
L-Histidine 1.5892 0.8425 1.0025 0.5658
L-Histidinol NA NA NA NA
L-Homoserine NA NA NA NA
Linoleylcarnitine 0.5338 1.0565 2.1193 0.2903
L-Isoleucine 1.0715 0.8450 1.2164 0.8672
L-Kynurenine 0.7467 0.7666 1.4455 1.0413
L-Lysine 1.1536 0.8459 1.2095 0.7910
L-Methionine 1.1657 0.8771 1.1622 0.7950
L-Palmitoylcarnitine 0.5976 1.1015 2.0075 0.2934
L-Phenylalanine 1.1213 0.8835 1.2338 0.7614
L-Proline 1.1941 0.9110 1.0270 0.8679
L-Serine 1.2145 0.9050 1.3155 0.5651
L-Tryptophan 1.1310 0.9039 1.2228 0.7424
L-Tyrosine 1.0640 0.8241 1.3992 0.7127
L-Valine 1.1423 0.8636 1.2260 0.7680
LysoPC(16:0) 2.0111 0.8267 0.4577 0.7045
LysoPC(18:0) 0.4507 0.4871 1.4378 1.6244
Malonylcarnitine 1.4628 0.7353 0.7485 1.0534
Melatonin NA NA NA NA
Metanephrine 0.9685 0.9345 1.2030 0.8941
Methionine sulfoxide 1.1993 0.7869 1.3282 0.6857
Methylcobalamin NA NA NA NA
Methylcysteine 1.1402 0.8226 1.2618 0.7755
Myristoylcarnitine 0.8234 1.0562 1.7377 0.3826
N-Acetylornithine NA NA NA NA
N-acetylputrescine NA NA NA NA
N-acetylserine 1.7564 0.7420 0.6361 0.8654
Niacinamide 1.1353 0.7490 1.3076 0.8081
Nicotinamide N-oxide NA NA NA NA
Norepinephrine 0.9528 0.5868 1.4232 1.0372
Normetanephrine NA NA NA NA
O-acetylserine NA NA NA NA
Octadecanoylcarnitine 0.3528 1.0128 2.4720 0.1623
Octanoylcarnitine 1.1025 0.8018 1.4827 0.6129
Oleoylcarnitine 0.3896 1.2213 2.2003 0.1888
O-Phosphoethanolamine 1.1394 0.8606 NA NA
O-Phosphotyrosine 1.1280 0.8375 1.0622 0.9723
Ornithine 1.2153 0.8163 1.1000 0.8684
O-succinylcarnitine 1.5476 0.7478 0.7677 0.9369
PC(16:0/16:0) 1.5276 0.6121 0.9963 0.8641
PC(16:0/18:1) 1.7475 0.4392 1.0644 0.7489
PC(16:0/18:2) 1.5893 0.5282 1.1465 0.7360
PC(16:0/20:4) 1.4588 0.4420 1.5130 0.5863
PC(16:0/22:6) 1.5507 0.5214 1.2724 0.6555
PC(18:0/18:2) NA NA NA NA
PC(18:0/20:3) NA NA NA NA
PC(18:1/18:1) 1.6013 0.5413 1.1237 0.7337
PC(18:3/22:4) 1.4782 0.5682 1.2708 0.6828
PC(20:4/P-16:0) 1.0813 0.4931 2.0883 0.3373
PC(20:5/P-16:0) 1.3180 0.4880 1.6903 0.5036
PC(22:0) NA NA NA NA
PC(22:1) 1.2873 0.9281 0.8540 0.9306
PC(22:6/P-18:0) 1.4234 0.6094 1.1419 0.8254
PC(24:0) NA NA NA NA
PC(24:0/P-18:0) 1.6620 0.4863 1.0766 0.7751
PC(24:1) NA NA NA NA
PC(26:0) 1.3930 0.5149 0.8757 1.2164
PC(26:1) 1.5492 0.5172 1.1431 0.7905
PC(28:0) 1.8406 0.5148 0.7520 0.8926
PC(28:1) 1.8780 0.3725 0.9507 0.7988
PC(28:2) 1.6864 0.5578 0.8792 0.8765
PC(30:0) 1.9040 0.4397 0.8340 0.8223
PC(30:1) 1.5913 0.6120 1.0089 0.7878
PC(30:2) 1.8047 0.4405 0.8273 0.9275
PC(32:1) 1.6221 0.5256 1.0769 0.7754
PC(32:2) 1.4949 0.6785 1.1035 0.7231
PC(34:1) 1.6965 0.4530 1.1076 0.7429
PC(34:2) NA NA NA NA
PC(36:0) 1.2604 0.4472 1.4874 0.8050
PC(36:1) 1.6679 0.4935 1.1108 0.7278
PC(38:5) 1.4787 0.5116 1.3925 0.6172
PC(40:6) 1.5741 0.4794 1.1527 0.7938
PG(16:0/16:0) NA NA NA NA
PG(18:0/18:0) NA NA NA NA
PG(32:1) 1.2012 0.7988 NA NA
PG(32:2) NA NA NA NA
PG(34:1) 1.7766 0.3285 0.8029 1.0920
PG(34:2) 1.3104 0.6080 1.4897 0.5918
PG(36:1) NA NA NA NA
PG(36:2) NA NA NA NA
PG(36:3) NA NA NA NA
PG(38:4) NA NA NA NA
PG(40:8) 1.6840 0.4203 1.1530 0.7426
PG(44:12) 1.9150 0.3141 0.7908 0.9800
Phosphorylcholine 1.6834 1.0137 0.5768 0.7261
Pimelylcarnitine NA NA NA NA
Propionylcarnitine 1.3858 0.8653 0.8881 0.8607
Purine 1.1361 0.9022 1.2555 0.7062
Pyridoxal NA NA NA NA
Pyridoxine NA NA 1.0763 0.9237
Retinal 1.0815 0.7850 1.3700 0.7635
Retinol 0.9580 0.8052 1.4412 0.7956
Saccharopine NA NA NA NA
S-Adenosylhomocysteine 0.6470 1.0238 0.9131 1.4161
S-Adenosylmethionine NA NA NA NA
Sarcosine 0.9610 0.8931 1.2071 0.9387
Serotonin 0.9904 0.6722 1.3210 1.0164
Suberylcarnitine NA NA NA NA
Testosterone NA NA NA NA
Tetradecanoylcarnitine 0.8261 1.0570 1.7207 0.3963
Tetrahydrobiopterin NA NA NA NA
THC 18:1/16:0 1.2583 0.9059 1.0143 0.8215
THC 18:1/18:0 0.9888 1.4572 0.7187 0.8352
THC 18:1/24:1 NA NA NA NA
Thiamine NA NA NA NA
Thiamine monophosphate NA NA NA NA
Thymidine 0.7842 1.4709 1.2279 0.5170
Thymine NA NA NA NA
Tiglylcarnitine NA NA NA NA
Tiglylglycine NA NA NA NA
Trimethylamine-N-oxide 1.1541 0.8099 1.1042 0.9319
Tyramine 0.9659 0.7769 1.2810 0.9763
Urea 1.0649 0.8575 1.1571 0.9205
Ureidopropionic acid 1.3091 0.7389 0.8884 1.0636
Uridine 5-monophosphate 0.7925 0.7383 1.1756 1.2935
Vitamin D3 1.0440 0.7717 1.2911 0.8933
Vitamin K2 1.3504 0.8127 1.0934 0.7435
Zymosterol 1.0494 0.7877 1.3915 0.7713
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Factors:

F1Time:24hr | Treatment:Control
F2Time:24hr | Treatment:Englerin (100 nM)
F3Time:48hr | Treatment:Control
F4Time:48hr | Treatment:Englerin (100 nM)
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