Data for Uniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response (Study ST000465)
(Analysis AN000727)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
1-Methyladenosine | 1.3250 | 1.0540 | 0.9397 | 0.6813 |
1-Methylhistamine | NA | NA | NA | NA |
1-Methylhistidine | 1.4097 | 0.7981 | 1.0406 | 0.7516 |
1-Methylnicotinamide | NA | NA | NA | NA |
1-Pyrroline-5-carboxylic acid | 1.3599 | 0.8239 | 1.0330 | 0.7831 |
24,25-Dihydrolanosterol | 1.2176 | 0.7473 | 1.3620 | 0.6732 |
24,25-Epoxycholesterol | 1.1724 | 0.7583 | 1.3178 | 0.7515 |
2-Arachidonylglycerol | 0.8133 | 0.8146 | 1.6098 | 0.7624 |
2-Deoxyguanosine 5-monophosphate | NA | NA | NA | NA |
2-Octenoylcarnitine | NA | NA | NA | NA |
3,3^,5^-Triiodothyronine | 1.1815 | 1.1329 | 0.7570 | 0.9286 |
3, 5-Tetradecadiencarnitine | 1.1968 | 1.0021 | 1.1715 | 0.6297 |
3-Hydroxyanthranilic acid | 0.4316 | 0.3665 | 1.7265 | 1.4754 |
3-Hydroxy-cis-5-tetradecenoylcarnitine | 0.7895 | 1.0082 | 1.7880 | 0.4143 |
3-Hydroxydodecanoylcarnitine | 1.5726 | 0.8169 | 0.7586 | 0.8519 |
3-Hydroxyhexadecanoylcarnitine | 1.0655 | 0.6619 | 1.5238 | 0.7488 |
3-Hydroxyhexadecenoylcarnitine | 0.4762 | 1.0378 | 2.2314 | 0.2546 |
3-Hydroxyhexanoylcarnitine | NA | NA | NA | NA |
3-Hydroxyiso-/butyrylcarnitine | 1.5118 | 0.7407 | 0.6878 | 1.0597 |
3-Hydroxyisovaleryl Carnitine | 1.5546 | 0.7916 | 0.7679 | 0.8858 |
3-Hydroxylinoleylcarnitine | 1.0099 | 0.8560 | 1.2760 | 0.8582 |
3-Hydroxyoleoylcarnitine | 0.4233 | 1.0340 | 2.2987 | 0.2439 |
5,6-trans-25-Hydroxyvitamin D3 | 1.4384 | 0.7686 | 0.9559 | 0.8372 |
5alpha-Cholestanol | NA | NA | NA | NA |
5-Methylthioadenosine | NA | NA | NA | NA |
7a-Hydroxycholesterol | 1.3782 | 0.8213 | 1.1458 | 0.6548 |
7-Dehydrocholesterol | 1.5235 | 0.6894 | 1.0313 | 0.7558 |
7-ketocholesterol | 1.5932 | 0.6837 | 0.8798 | 0.8433 |
7-Methylguanosine | 0.9574 | 0.8809 | 1.3465 | 0.8152 |
9-Decenoylcarnitine | 1.1508 | 0.8936 | 1.1140 | 0.8416 |
9-Hexadecenoylcarnitine | 0.6114 | 1.1370 | 1.9901 | 0.2615 |
Acetylcholine | 1.4737 | 0.8921 | 0.8134 | 0.8207 |
Adenine | NA | NA | NA | NA |
Adenosine | 0.2300 | 0.7629 | 2.0967 | 0.9104 |
Adenosine monophosphate | 0.5840 | 0.2406 | 1.5375 | 1.6380 |
Adenosine triphosphate | NA | NA | NA | NA |
Adipoylcarnitine | 1.1700 | 0.7077 | 1.1181 | 1.0041 |
Agmatine | NA | NA | NA | NA |
Alanine | 0.9578 | 0.8891 | 1.2200 | 0.9331 |
Alpha-Tocopherol | 1.3771 | 0.7285 | 1.0034 | 0.8910 |
Amphetamine | 1.0791 | 0.8423 | 1.3946 | 0.6840 |
Anandamide | NA | NA | NA | NA |
Anserine | NA | NA | NA | NA |
Arachidonyl carnitine | 1.1416 | 0.7600 | 1.0614 | 1.0370 |
B-Carotene | 1.2732 | 0.7489 | 1.2179 | 0.7601 |
beta-Alanine | 1.4148 | 1.0172 | 0.7373 | 0.8306 |
Betaine | 1.2363 | 0.7958 | 1.1089 | 0.8591 |
Betaine aldehyde | NA | NA | NA | NA |
Bilirubin | NA | NA | NA | NA |
Biotin | 1.0791 | 0.8074 | 0.9737 | 1.1398 |
BMP(16:0/16:0) | NA | NA | NA | NA |
BMP(18:1/16:0) | NA | NA | NA | NA |
BMP(18:1/16:1) | NA | NA | NA | NA |
BMP(18:1/18:0) | NA | NA | NA | NA |
BMP(18:1/18:1) | NA | NA | NA | NA |
BMP(18:1/18:2) | NA | NA | NA | NA |
BMP(18:1/20:4) | NA | NA | NA | NA |
BMP(18:1/22:5) | NA | NA | NA | NA |
BMP(18:1/22:6) | NA | NA | NA | NA |
BMP(20:4/22:6) | NA | NA | NA | NA |
BMP(22:5/22:6) | NA | NA | NA | NA |
BMP(22:6/22:6) | NA | NA | NA | NA |
Butyrylcarnitine | 1.3664 | 0.8777 | 0.9393 | 0.8165 |
Carnosine | 1.1329 | 0.8359 | 1.1017 | 0.9294 |
Ceramide(d18:1/12:0) | NA | NA | NA | NA |
Ceramide(d18:1/16:0) | 0.8972 | 1.3941 | 1.0016 | 0.7070 |
Ceramide(d18:1/16:0 OH) | 1.4565 | 0.7546 | 1.0021 | 0.7868 |
Ceramide(d18:1/16:1) | 1.4118 | 0.5958 | 1.2882 | 0.7042 |
Ceramide(d18:1/16:1 OH) | 0.8662 | 1.4711 | 0.9233 | 0.7393 |
Ceramide(d18:1/16:2) | NA | NA | NA | NA |
Ceramide(d18:1/16:2 OH) | NA | NA | NA | NA |
Ceramide(d18:1/18:0) | 0.3557 | 1.9328 | 0.6348 | 1.0766 |
Ceramide(d18:1/18:0 OH) | 1.6233 | 0.5526 | 1.0339 | 0.7902 |
Ceramide(d18:1/18:1) | 1.5478 | 0.6958 | 1.1340 | 0.6224 |
Ceramide(d18:1/18:1 OH) | NA | NA | NA | NA |
Ceramide(d18:1/18:2) | NA | NA | NA | NA |
Ceramide(d18:1/18:2 OH) | NA | NA | NA | NA |
Ceramide(d18:1/20:0) | NA | NA | NA | NA |
Ceramide(d18:1/20:0 OH) | NA | NA | NA | NA |
Ceramide(d18:1/20:1) | NA | NA | NA | NA |
Ceramide(d18:1/20:1 OH) | NA | NA | NA | NA |
Ceramide(d18:1/20:2) | NA | NA | NA | NA |
Ceramide(d18:1/20:2 OH) | NA | NA | NA | NA |
Ceramide(d18:1/22:0) | NA | NA | 0.9548 | 1.0452 |
Ceramide(d18:1/22:0 OH) | NA | NA | NA | NA |
Ceramide(d18:1/22:1) | NA | NA | NA | NA |
Ceramide(d18:1/22:2) | NA | NA | NA | NA |
Ceramide(d18:1/22:2 OH) | NA | NA | NA | NA |
Ceramide(d18:1/23:0) or Ceramide(d18:1/22:1 OH) | NA | NA | NA | NA |
Ceramide(d18:1/24:0) | NA | NA | NA | NA |
Ceramide(d18:1/24:0 OH) | 0.1940 | 2.1137 | 0.9486 | 0.7436 |
Ceramide(d18:1/24:1) | 0.2074 | 1.9807 | 1.1019 | 0.7100 |
Ceramide(d18:1/24:2) | NA | NA | NA | NA |
Ceramide(d18:1/24:2 OH) | NA | NA | NA | NA |
Ceramide(d18:1/25:0) | 0.1461 | 2.6534 | 0.4955 | 0.7050 |
Ceramide(d18:1/26:0) | NA | NA | NA | NA |
Ceramide(d18:1/26:0 OH) | NA | NA | NA | NA |
Ceramide(d18:1/26:1) | NA | NA | NA | NA |
Ceramide(d18:1/26:1 OH) | NA | NA | NA | NA |
Ceramide(d18:1/26:2) | NA | NA | NA | NA |
Ceramide(d18:1/26:2 OH) | NA | NA | NA | NA |
Cholesterol | 0.3707 | 1.5089 | 0.7077 | 1.4127 |
Choline | 1.2339 | 0.8071 | 1.1006 | 0.8585 |
Cobalamin | 1.2980 | 0.6853 | 1.2136 | 0.8031 |
Coenzyme Q10 | NA | NA | NA | NA |
Coenzyme Q9 | NA | NA | NA | NA |
CoQ10H2 | NA | NA | NA | NA |
CoQ9H2 | NA | NA | NA | NA |
Corticosterone | 1.1622 | 0.9064 | 1.2691 | 0.6623 |
Cortisone | 1.4117 | 1.0973 | 0.7653 | 0.7257 |
Creatinine | 1.3211 | 0.9555 | 0.9902 | 0.7332 |
Cyanocobalamin | 1.2110 | 0.8557 | 1.0747 | 0.8586 |
Cysteamine | NA | NA | NA | NA |
Cysteine | 1.1714 | 1.0242 | 1.0745 | 0.7299 |
Cysteineglutathione disulfide | NA | NA | NA | NA |
Cytidine | 0.4013 | 2.4437 | 0.9892 | 0.1658 |
Cytidine monophosphate | 0.9914 | 1.1775 | 1.0611 | 0.7701 |
Cytosine | 1.7875 | 0.8002 | 0.7311 | 0.6812 |
Decanoylcarnitine | 1.0327 | 0.7167 | 1.6666 | 0.5840 |
Dehydroepiandrosterone | NA | NA | NA | NA |
Deoxyadenosine | NA | NA | NA | NA |
Deoxyadenosine monophosphate | 1.4182 | 0.7912 | 0.7482 | 1.0424 |
Deoxycytidine monophosphate | 1.9992 | 0.8211 | 0.6490 | 0.5308 |
Deoxyinosine monophosphate | 0.8399 | 0.6624 | 1.2293 | 1.2684 |
Deoxyuridine monophosphate | NA | NA | NA | NA |
Desmosterol | 1.3349 | 0.7370 | 1.0580 | 0.8701 |
DHC(18:1/16:0) | 1.1656 | 0.8505 | 1.3207 | 0.6632 |
DHC(18:1/22:0) | NA | NA | NA | NA |
DHC(18:1/24:0) | NA | NA | NA | NA |
DHC(18:1/24:1) | NA | NA | NA | NA |
Dimethylglycine | 1.3106 | 0.8165 | 1.0416 | 0.8313 |
Dimethyl-L-arginine | 1.4626 | 0.8257 | 0.9364 | 0.7753 |
Dodecanoylcarnitine | 1.0382 | 0.7909 | 1.6110 | 0.5599 |
Dodecenoylcarnitine | 1.0325 | 0.8028 | 1.4065 | 0.7583 |
Dopamine | 0.9461 | 1.0035 | 1.4413 | 0.6090 |
Epicatechin | NA | NA | NA | NA |
Epinephrine | NA | NA | NA | NA |
Ergosterol | 0.9318 | 1.0809 | 1.1446 | 0.8427 |
Estradiol | NA | NA | NA | NA |
Estriol | NA | NA | NA | NA |
Estrone | NA | NA | NA | NA |
Ethanolamine | NA | NA | NA | NA |
FMN | NA | NA | NA | NA |
Gamma-glutamyl-Alanine | NA | NA | NA | NA |
Gamma-glutamyl-Cysteine | NA | NA | NA | NA |
Gamma-glutamyl-Isoleucine | 0.8291 | 0.6592 | 1.8598 | 0.6520 |
Gamma-glutamyl-Valine | NA | NA | NA | NA |
GC(18:1/16:0) | 0.2626 | 1.5199 | 1.9401 | 0.2774 |
GC(18:1/20:0) | 0.0677 | 2.6307 | 1.0040 | 0.2976 |
GC(18:1/22:0) | 0.0211 | 2.8740 | 0.7499 | 0.3550 |
GC(18:1/24:0) | NA | NA | NA | NA |
GC(18:1/24:1) | 0.0577 | 2.5250 | 1.0794 | 0.3379 |
Gluconolactone | 1.4022 | 1.0428 | 1.0375 | 0.5175 |
Glucosamine | NA | NA | NA | NA |
Glyceraldehyde | 1.2638 | 0.8465 | 1.1765 | 0.7132 |
Glycerophosphocholine | 0.9049 | 1.1786 | 1.3784 | 0.5382 |
Glycine | 0.9942 | 0.9248 | 1.4141 | 0.6670 |
Guanosine | NA | NA | NA | NA |
Guanosine monophosphate | 0.6885 | 0.8443 | 0.9749 | 1.4923 |
Hexanoylcarnitine | NA | NA | NA | NA |
Histamine | 1.6882 | 0.9001 | 0.7557 | 0.6559 |
Homocysteine | NA | NA | NA | NA |
Hydroxycholesterol Species | 1.5175 | 0.6295 | 1.2741 | 0.5789 |
Hydroxykynurenine | NA | NA | NA | NA |
Hydroxyproline | 1.3148 | 0.7973 | 1.0624 | 0.8255 |
Hypoxanthine | 0.8460 | 1.0969 | 1.5560 | 0.5010 |
Indole | 1.1579 | 0.9130 | 1.2629 | 0.6662 |
Indoleacrylic acid | NA | NA | NA | NA |
Isovalerylcarnitine | 1.3599 | 0.8820 | 0.9409 | 0.8172 |
L-Acetylcarnitine | 1.4243 | 0.7705 | 0.7638 | 1.0413 |
Lanosterin | 1.8464 | 0.5891 | 0.9184 | 0.6461 |
L-Asparagine | 1.2995 | 0.8149 | 1.1871 | 0.6985 |
Lathosterol | 1.1719 | 0.7315 | 1.5032 | 0.5934 |
L-Carnitine | 1.6084 | 0.7261 | 0.7824 | 0.8831 |
L-Cystathionine | 1.3491 | 0.7970 | 0.8781 | 0.9759 |
L-Glutamine | 1.1392 | 0.8431 | 1.2074 | 0.8103 |
L-Glutarylcarnitine | NA | NA | NA | NA |
L-Histidine | 1.5892 | 0.8425 | 1.0025 | 0.5658 |
L-Histidinol | NA | NA | NA | NA |
L-Homoserine | NA | NA | NA | NA |
Linoleylcarnitine | 0.5338 | 1.0565 | 2.1193 | 0.2903 |
L-Isoleucine | 1.0715 | 0.8450 | 1.2164 | 0.8672 |
L-Kynurenine | 0.7467 | 0.7666 | 1.4455 | 1.0413 |
L-Lysine | 1.1536 | 0.8459 | 1.2095 | 0.7910 |
L-Methionine | 1.1657 | 0.8771 | 1.1622 | 0.7950 |
L-Palmitoylcarnitine | 0.5976 | 1.1015 | 2.0075 | 0.2934 |
L-Phenylalanine | 1.1213 | 0.8835 | 1.2338 | 0.7614 |
L-Proline | 1.1941 | 0.9110 | 1.0270 | 0.8679 |
L-Serine | 1.2145 | 0.9050 | 1.3155 | 0.5651 |
L-Tryptophan | 1.1310 | 0.9039 | 1.2228 | 0.7424 |
L-Tyrosine | 1.0640 | 0.8241 | 1.3992 | 0.7127 |
L-Valine | 1.1423 | 0.8636 | 1.2260 | 0.7680 |
LysoPC(16:0) | 2.0111 | 0.8267 | 0.4577 | 0.7045 |
LysoPC(18:0) | 0.4507 | 0.4871 | 1.4378 | 1.6244 |
Malonylcarnitine | 1.4628 | 0.7353 | 0.7485 | 1.0534 |
Melatonin | NA | NA | NA | NA |
Metanephrine | 0.9685 | 0.9345 | 1.2030 | 0.8941 |
Methionine sulfoxide | 1.1993 | 0.7869 | 1.3282 | 0.6857 |
Methylcobalamin | NA | NA | NA | NA |
Methylcysteine | 1.1402 | 0.8226 | 1.2618 | 0.7755 |
Myristoylcarnitine | 0.8234 | 1.0562 | 1.7377 | 0.3826 |
N-Acetylornithine | NA | NA | NA | NA |
N-acetylputrescine | NA | NA | NA | NA |
N-acetylserine | 1.7564 | 0.7420 | 0.6361 | 0.8654 |
Niacinamide | 1.1353 | 0.7490 | 1.3076 | 0.8081 |
Nicotinamide N-oxide | NA | NA | NA | NA |
Norepinephrine | 0.9528 | 0.5868 | 1.4232 | 1.0372 |
Normetanephrine | NA | NA | NA | NA |
O-acetylserine | NA | NA | NA | NA |
Octadecanoylcarnitine | 0.3528 | 1.0128 | 2.4720 | 0.1623 |
Octanoylcarnitine | 1.1025 | 0.8018 | 1.4827 | 0.6129 |
Oleoylcarnitine | 0.3896 | 1.2213 | 2.2003 | 0.1888 |
O-Phosphoethanolamine | 1.1394 | 0.8606 | NA | NA |
O-Phosphotyrosine | 1.1280 | 0.8375 | 1.0622 | 0.9723 |
Ornithine | 1.2153 | 0.8163 | 1.1000 | 0.8684 |
O-succinylcarnitine | 1.5476 | 0.7478 | 0.7677 | 0.9369 |
PC(16:0/16:0) | 1.5276 | 0.6121 | 0.9963 | 0.8641 |
PC(16:0/18:1) | 1.7475 | 0.4392 | 1.0644 | 0.7489 |
PC(16:0/18:2) | 1.5893 | 0.5282 | 1.1465 | 0.7360 |
PC(16:0/20:4) | 1.4588 | 0.4420 | 1.5130 | 0.5863 |
PC(16:0/22:6) | 1.5507 | 0.5214 | 1.2724 | 0.6555 |
PC(18:0/18:2) | NA | NA | NA | NA |
PC(18:0/20:3) | NA | NA | NA | NA |
PC(18:1/18:1) | 1.6013 | 0.5413 | 1.1237 | 0.7337 |
PC(18:3/22:4) | 1.4782 | 0.5682 | 1.2708 | 0.6828 |
PC(20:4/P-16:0) | 1.0813 | 0.4931 | 2.0883 | 0.3373 |
PC(20:5/P-16:0) | 1.3180 | 0.4880 | 1.6903 | 0.5036 |
PC(22:0) | NA | NA | NA | NA |
PC(22:1) | 1.2873 | 0.9281 | 0.8540 | 0.9306 |
PC(22:6/P-18:0) | 1.4234 | 0.6094 | 1.1419 | 0.8254 |
PC(24:0) | NA | NA | NA | NA |
PC(24:0/P-18:0) | 1.6620 | 0.4863 | 1.0766 | 0.7751 |
PC(24:1) | NA | NA | NA | NA |
PC(26:0) | 1.3930 | 0.5149 | 0.8757 | 1.2164 |
PC(26:1) | 1.5492 | 0.5172 | 1.1431 | 0.7905 |
PC(28:0) | 1.8406 | 0.5148 | 0.7520 | 0.8926 |
PC(28:1) | 1.8780 | 0.3725 | 0.9507 | 0.7988 |
PC(28:2) | 1.6864 | 0.5578 | 0.8792 | 0.8765 |
PC(30:0) | 1.9040 | 0.4397 | 0.8340 | 0.8223 |
PC(30:1) | 1.5913 | 0.6120 | 1.0089 | 0.7878 |
PC(30:2) | 1.8047 | 0.4405 | 0.8273 | 0.9275 |
PC(32:1) | 1.6221 | 0.5256 | 1.0769 | 0.7754 |
PC(32:2) | 1.4949 | 0.6785 | 1.1035 | 0.7231 |
PC(34:1) | 1.6965 | 0.4530 | 1.1076 | 0.7429 |
PC(34:2) | NA | NA | NA | NA |
PC(36:0) | 1.2604 | 0.4472 | 1.4874 | 0.8050 |
PC(36:1) | 1.6679 | 0.4935 | 1.1108 | 0.7278 |
PC(38:5) | 1.4787 | 0.5116 | 1.3925 | 0.6172 |
PC(40:6) | 1.5741 | 0.4794 | 1.1527 | 0.7938 |
PG(16:0/16:0) | NA | NA | NA | NA |
PG(18:0/18:0) | NA | NA | NA | NA |
PG(32:1) | 1.2012 | 0.7988 | NA | NA |
PG(32:2) | NA | NA | NA | NA |
PG(34:1) | 1.7766 | 0.3285 | 0.8029 | 1.0920 |
PG(34:2) | 1.3104 | 0.6080 | 1.4897 | 0.5918 |
PG(36:1) | NA | NA | NA | NA |
PG(36:2) | NA | NA | NA | NA |
PG(36:3) | NA | NA | NA | NA |
PG(38:4) | NA | NA | NA | NA |
PG(40:8) | 1.6840 | 0.4203 | 1.1530 | 0.7426 |
PG(44:12) | 1.9150 | 0.3141 | 0.7908 | 0.9800 |
Phosphorylcholine | 1.6834 | 1.0137 | 0.5768 | 0.7261 |
Pimelylcarnitine | NA | NA | NA | NA |
Propionylcarnitine | 1.3858 | 0.8653 | 0.8881 | 0.8607 |
Purine | 1.1361 | 0.9022 | 1.2555 | 0.7062 |
Pyridoxal | NA | NA | NA | NA |
Pyridoxine | NA | NA | 1.0763 | 0.9237 |
Retinal | 1.0815 | 0.7850 | 1.3700 | 0.7635 |
Retinol | 0.9580 | 0.8052 | 1.4412 | 0.7956 |
Saccharopine | NA | NA | NA | NA |
S-Adenosylhomocysteine | 0.6470 | 1.0238 | 0.9131 | 1.4161 |
S-Adenosylmethionine | NA | NA | NA | NA |
Sarcosine | 0.9610 | 0.8931 | 1.2071 | 0.9387 |
Serotonin | 0.9904 | 0.6722 | 1.3210 | 1.0164 |
Suberylcarnitine | NA | NA | NA | NA |
Testosterone | NA | NA | NA | NA |
Tetradecanoylcarnitine | 0.8261 | 1.0570 | 1.7207 | 0.3963 |
Tetrahydrobiopterin | NA | NA | NA | NA |
THC 18:1/16:0 | 1.2583 | 0.9059 | 1.0143 | 0.8215 |
THC 18:1/18:0 | 0.9888 | 1.4572 | 0.7187 | 0.8352 |
THC 18:1/24:1 | NA | NA | NA | NA |
Thiamine | NA | NA | NA | NA |
Thiamine monophosphate | NA | NA | NA | NA |
Thymidine | 0.7842 | 1.4709 | 1.2279 | 0.5170 |
Thymine | NA | NA | NA | NA |
Tiglylcarnitine | NA | NA | NA | NA |
Tiglylglycine | NA | NA | NA | NA |
Trimethylamine-N-oxide | 1.1541 | 0.8099 | 1.1042 | 0.9319 |
Tyramine | 0.9659 | 0.7769 | 1.2810 | 0.9763 |
Urea | 1.0649 | 0.8575 | 1.1571 | 0.9205 |
Ureidopropionic acid | 1.3091 | 0.7389 | 0.8884 | 1.0636 |
Uridine 5-monophosphate | 0.7925 | 0.7383 | 1.1756 | 1.2935 |
Vitamin D3 | 1.0440 | 0.7717 | 1.2911 | 0.8933 |
Vitamin K2 | 1.3504 | 0.8127 | 1.0934 | 0.7435 |
Zymosterol | 1.0494 | 0.7877 | 1.3915 | 0.7713 |
Factors:
F1 | Time:24hr | Treatment:Control |
F2 | Time:24hr | Treatment:Englerin (100 nM) |
F3 | Time:48hr | Treatment:Control |
F4 | Time:48hr | Treatment:Englerin (100 nM) |