Data for Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant Plasmodium (Study ST000546)
(Analysis AN000833)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
1-18:2-2-18:2-monogalactosyldiacylglycerol | 0.8432 | 0.9093 | 0.8327 | 1.3111 |
1-Deoxy-D-altro-heptulose 7-phosphate | 0.9708 | 0.8377 | 1.1915 | NA |
1-Sinapoyl-D-glucose | 0.8741 | 0.8591 | 1.2045 | 1.0623 |
1-thio-beta-D-glucose | 0.8990 | 0.8288 | 1.2722 | NA |
2-16:0-lysoPG | 0.8736 | 0.8009 | 1.3255 | NA |
2,3-Bisphospho-D-glycerate | 0.6059 | 0.4236 | 0.4500 | 2.1404 |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate | 0.3284 | 0.3328 | 0.4507 | 2.4161 |
2-C-Methyl-D-erythritol 4-phosphate | 1.0014 | 0.6570 | 0.7892 | 1.4143 |
2-Dehydro-3-deoxy-D-gluconate | 0.4060 | 0.4257 | 0.4329 | 2.3016 |
2-Deoxy-2,3-dehydro-N-acetylneuraminic acid | 0.4744 | 0.3801 | 0.4001 | 2.3091 |
2-Hydroxy-1,3-dimethoxy-8,9-methylenedioxycoumestan | 1.1306 | 1.0166 | 1.1047 | 0.8111 |
2-Oxoglutaramate | 1.0268 | 1.4336 | 1.5400 | 0.2497 |
2-Oxoglutarate | 0.9194 | 1.0255 | 0.6366 | 1.3139 |
3-beta-D-Galactosyl-sn-glycerol | 0.4020 | 0.4266 | 0.4347 | 2.3025 |
3-Cyano-L-alanine | 1.1258 | 1.2924 | 0.9570 | 0.7185 |
3-Oxopropanoate | 0.8367 | 0.6150 | 0.7110 | 1.6279 |
3-Phospho-D-glycerate | 0.8113 | 0.5372 | 0.5067 | 1.8586 |
4-Amino-4-deoxychorismate | 0.7056 | 0.6173 | 0.6012 | 1.8070 |
4-Hydroxyphenylacetylglycine | 0.7676 | 0.5488 | 0.5942 | 1.8170 |
4-Methyl-2-oxopentanoate | 0.6151 | 0.6563 | 0.5582 | 1.8778 |
4-oxo-4-(3-pyridyl)-butanoate | 0.4090 | 0.3174 | 0.4859 | 2.3407 |
5-Acetyl-2,4-dimethyloxazole | 0.7374 | 0.6480 | 0.6306 | 1.7380 |
5-L-Glutamylglycine | 1.0599 | 1.3282 | 1.0999 | 0.6340 |
6-Phospho-D-gluconate | 1.3202 | 0.7805 | 0.8507 | 1.0365 |
7-Methyl-3-oxooctanoyl-CoA | 0.7229 | 0.5155 | 0.5524 | 1.9069 |
Acetyl phosphate | 0.8761 | 0.7781 | 0.4917 | 1.6406 |
ADP-ribose | 1.1704 | 0.9388 | 0.8908 | NA |
Ala-Glu-Ala-Glu | 0.8215 | 1.2371 | 0.9415 | NA |
Ala-Gly-Tyr | 1.2665 | 1.1728 | 1.1876 | 0.0596 |
Ala-Lys-Asp-Pro | 0.7232 | 1.3189 | 0.9579 | NA |
Ala-Ser | 1.0593 | 1.7462 | 1.4017 | 0.0946 |
Allogibberic acid | 0.3621 | 0.3382 | 0.3195 | 2.4852 |
AMCC | 0.8580 | 0.8979 | 1.2441 | NA |
ancymidol | 0.8096 | 0.7410 | 0.6897 | 1.5699 |
Arg-Cys-Cys-Tyr | 1.1737 | 0.6486 | 1.1777 | NA |
Asn-Met-Thr-Asp | 0.5897 | 0.5534 | 0.7317 | 1.8439 |
Asn-Ser | 1.0320 | 1.1022 | 0.8658 | NA |
Asp-Gln | 0.7434 | 1.0627 | 1.1939 | NA |
Asp-Phe-Pro-Tyr | 1.3608 | 0.9244 | 0.7149 | NA |
Asp-Ser-Tyr-Tyr | 1.3141 | 0.7913 | 0.8946 | NA |
Asp-Trp-Asp-Gln | 0.3997 | 0.4796 | 0.4546 | 2.2496 |
Benzyl sulfate | 0.8659 | 0.7057 | 0.8775 | 1.3796 |
Bergaptol | 0.6572 | 0.5622 | 0.4526 | 1.9960 |
Betaine | 0.3896 | 0.4193 | 0.3777 | 2.3600 |
Cholate | 1.1220 | 1.0461 | 0.8455 | 1.0203 |
Cholesterolsulfate | 0.6403 | 0.5413 | 0.4964 | 1.9915 |
cis-(homo)3aconitate | 0.7284 | 0.6609 | 0.5272 | 1.8126 |
Citrate | 0.3892 | 0.3230 | 0.3575 | 2.4478 |
CMP | 0.9364 | 1.2377 | 0.8047 | NA |
CMP-2-aminoethylphosphonate | 0.8066 | 0.8283 | 0.7653 | 1.4498 |
Cyclic 2,3-bisphospho-D-glycerate | 0.5767 | 0.3774 | 0.4622 | 2.1877 |
Cyclic ADP-ribose | 1.3175 | 1.2078 | 1.0242 | 0.5879 |
Cys-Leu-Cys-Tyr | 1.2880 | 0.9820 | 0.8968 | 0.4996 |
Cys-Lys-Ser-Ser | 1.0602 | 1.6374 | 1.2048 | 0.3232 |
D-4^-Phosphopantothenate | 0.9791 | 0.9190 | 1.1018 | NA |
deacetylcolchicine | 0.7138 | 0.5884 | 0.4271 | 1.9530 |
D-Erythrose | 0.3459 | 0.3856 | 0.5399 | 2.2964 |
D-Fructose | 0.9195 | 0.7807 | 0.9002 | 1.2997 |
D-Gluconic acid | 0.3509 | 0.3653 | 0.3698 | 2.4355 |
D-Glucosamine | 0.2960 | 0.3655 | 0.3267 | 2.5088 |
D-Glucose 6-phosphate | 1.2398 | 1.1432 | 0.9619 | 0.7414 |
D-Glucuronate | 0.7204 | 0.5101 | 0.4958 | 1.9553 |
D-Glycerate | 0.4795 | 0.5159 | 0.6456 | 2.0193 |
Dide-O-methylsimmondsin | 0.3392 | 0.4096 | 0.3108 | 2.4554 |
D-Mannitol 1-phosphate | 0.9957 | 0.8611 | 0.8179 | 1.2440 |
D-Ribose 5-phosphate | 0.9983 | 0.4959 | 0.5019 | 1.7530 |
D-Sedoheptulose 7-phosphate | 0.6471 | 0.4540 | 0.5088 | 2.0426 |
D-Sorbitol | 0.2746 | 0.2963 | 0.2930 | 2.6021 |
D-Xylonate | 0.2636 | 0.2277 | 0.2672 | 2.6811 |
D-Xylonolactone | 0.8627 | 0.5799 | 0.4936 | 1.7978 |
FA(16:0) | 0.9568 | 0.4685 | 0.5153 | 1.7945 |
[FA (18:1)] 9Z-octadecenoic acid | 0.9096 | 0.8281 | 0.9917 | 1.2029 |
[FA (18:3)] 9Z,12Z,15Z-octadecatrienoic acid | 0.9136 | 0.9401 | 1.0526 | 1.0703 |
FA (19:1) | 0.7946 | 0.7797 | 0.8958 | 1.3975 |
FA (20:0) | 0.9017 | 0.6306 | 0.5506 | 1.6878 |
[FA (20:1)] 11Z-eicosenoic acid | 0.9257 | 0.8711 | 0.7454 | 1.3433 |
FA (20:4) | 0.9755 | 0.8585 | 1.0964 | 1.0522 |
[FA (22:5)] 7Z,10Z,13Z,16Z,19Z-docosapentaenoic acid | 0.8800 | 0.8444 | 0.8987 | 1.2826 |
FA hydroxy(10:0) | 0.9550 | 0.7113 | 0.5108 | 1.6172 |
[FA trihydroxy(4:0)] 2,3,4-trihydroxy-butanoic acid | 0.5009 | 0.5316 | 0.6302 | 2.0030 |
Fumarate | 0.6818 | 0.5970 | 0.6468 | 1.8058 |
gamma-L-Glutamyl-D-alanine | 0.7769 | 1.1284 | 1.0948 | NA |
Gln-Leu-Lys-Tyr | 0.7601 | 0.6659 | 0.4914 | 1.8120 |
Gln-Met-Met-Thr | 1.0517 | 0.8640 | 1.0843 | NA |
Glycerol | 1.0900 | 1.2481 | 0.9143 | 0.8107 |
Glycochenodeoxycholate | 1.0632 | 0.8854 | 0.9625 | 1.0825 |
Glycyl-Serine | 0.9522 | 0.9240 | 1.1238 | NA |
Gravacridonetriol glucoside | 0.6211 | 0.6240 | 0.4727 | 1.9616 |
HEPES | 1.3855 | 1.0399 | 1.2039 | 0.5281 |
Histidinyl-Asparagine | 0.7539 | 1.1587 | 1.0873 | NA |
Hydantoin-5-propionate | 1.2819 | 1.7640 | 1.1539 | 0.1002 |
Hydroxymethylphosphonate | 1.2179 | 0.8571 | 0.7515 | 1.1301 |
Icosadienoic acid | 1.0177 | 0.6183 | 1.0548 | 1.4638 |
Icosatrienoic acid | 0.9596 | 0.8867 | 1.0390 | 1.0860 |
Ile-His-Val | 1.0919 | 0.8592 | 1.0489 | NA |
Ile-Thr | 0.8644 | 1.2270 | 0.9086 | NA |
Imidazole-4-acetaldehyde | 0.4546 | 0.4565 | 0.4851 | 2.2029 |
Kinobscurinone | 0.9829 | 1.0357 | 1.0153 | 0.9746 |
LacCer(d32:1) | 0.8829 | 0.9426 | 0.4900 | 1.5133 |
L-Aspartate | 0.7074 | 0.6471 | 0.6520 | 1.7451 |
L-beta-aspartyl-L-serine | 0.8880 | 1.6351 | 1.5874 | 0.1671 |
L-Cysteate | 0.7980 | 0.7007 | 0.9150 | 1.4397 |
L-Cysteine | 1.1348 | 0.7393 | 1.1259 | NA |
L-prolyl-L-glycine | 1.2554 | 1.4445 | 0.9365 | 0.3636 |
LysoPA(16:0) | 0.5263 | 0.5387 | 0.5185 | 2.0624 |
LysoPA(18:0) | 0.5548 | 0.5311 | 0.3818 | 2.1493 |
LysoPE(18:0) | 0.9216 | 0.8107 | 1.0044 | 1.1975 |
LysoPE(18:2) | 0.7473 | 0.7245 | 1.0914 | 1.3276 |
LysoPE(18:3) | 0.9249 | 0.8113 | 1.2638 | NA |
LysoPE(20:4) | 0.6313 | 0.5668 | 0.5880 | 1.9104 |
LysoPE(20:5) | 1.1949 | 0.9598 | 1.1532 | 0.6921 |
LysoPE(22:5) | 0.9022 | 0.7272 | 0.8477 | 1.3921 |
Maleamate | 1.5182 | 1.1343 | 1.2399 | 0.3307 |
Melibiitol | 0.6302 | 0.7825 | 0.7897 | 1.5981 |
melibionate | 0.6088 | 0.4859 | 0.5138 | 2.0437 |
Met-Met-Ala | 0.7321 | 1.2828 | 0.9851 | NA |
Met-Thr-Asp | 1.1150 | 0.6202 | 0.5674 | 1.5230 |
Miroestrol | 0.9553 | 0.7079 | 0.6255 | 1.5335 |
N2-Succinyl-L-ornithine | 1.2148 | 1.6694 | 1.3764 | 0.0545 |
N-Acetyl-D-glucosaminate | 0.4324 | 0.3766 | 0.3609 | 2.3725 |
N-Acetyl-D-glucosamine 6-phosphate | 0.5644 | 0.5550 | 0.5254 | 2.0164 |
N-Acetyl-D-mannosaminolactone | 0.9571 | 0.9795 | 1.1728 | 0.9179 |
N-Acetyl-L-citrulline | 0.7336 | 1.2752 | 0.9912 | NA |
N-Acetyl-L-glutamate | 1.3595 | 1.1992 | 1.0612 | 0.5350 |
N-Acetylmethionine | 1.1297 | 1.2507 | 1.4362 | 0.3875 |
N-Amidino-L-glutamate | 1.0326 | 0.9300 | 1.0374 | NA |
N-D-Glucosylarylamine | 0.8091 | 0.6815 | 0.6415 | 1.6509 |
nonulose 9-phosphate | 0.7797 | 0.5488 | 0.5090 | 1.8719 |
N-Succinyl-L-glutamate | 0.8761 | 1.0725 | 1.0513 | NA |
octulose 8-phosphate | 0.3455 | 0.3042 | 0.3996 | 2.4630 |
Orotate(Fragment) | 1.3550 | 1.2324 | 1.4047 | 0.2560 |
Orotidine | 0.5267 | 0.5346 | 0.4448 | 2.1204 |
Orthophosphate | 0.7505 | 0.5900 | 0.4893 | 1.8777 |
[PA(16:0/18:1)] 1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphate | 0.8067 | 0.7574 | 0.6871 | 1.5616 |
PA(18:1(9Z)/0:0) | 0.5912 | 0.6894 | 0.6508 | 1.8014 |
PA(34:2) | 0.7151 | 0.6213 | 0.5574 | 1.8297 |
PA(36:3) | 0.7091 | 0.6503 | 0.5551 | 1.8141 |
PA(36:4) | 0.6344 | 0.6326 | 0.4968 | 1.9272 |
PE(14:0/20:2(11Z,14Z)) | 1.1910 | 1.2055 | 0.9582 | 0.7340 |
[PE(18:1/16:0)] 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine | 0.9916 | 1.2486 | 1.0470 | 0.7846 |
[PE(18:2/18:2)] 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine | 0.8898 | 0.9598 | 0.8052 | 1.2589 |
PE(30:4) | 0.7925 | 0.7907 | 0.6857 | 1.5483 |
PE(31:4) | 0.7327 | 0.7167 | 0.6307 | 1.6899 |
PE(36:1) | 1.1966 | 1.1563 | 1.1970 | 0.5876 |
PE(36:3) | 0.6808 | 0.5817 | 0.5208 | 1.9125 |
PE(38:5) | 0.6605 | 0.6267 | 0.4704 | 1.9318 |
PE(P-38:4) | 0.3980 | 0.3494 | 0.2609 | 2.4939 |
PE(P-40:4) | 0.4894 | 0.3536 | 0.2920 | 2.3987 |
[PG (18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1^-sn-glycerol) | 0.8478 | 0.9312 | 1.2209 | NA |
[PG (18:1)] 1-(9E-octadecenoyl)-sn-glycero-3-phospho-(1^-sn-glycerol) | 0.8887 | 0.8196 | 1.2916 | NA |
PG(33:1) | 1.0021 | 0.8637 | 1.1342 | NA |
PG(34:1) | 1.2278 | 1.1800 | 1.6249 | 0.2255 |
PG(34:2) | 1.1001 | 1.0687 | 1.4642 | 0.0506 |
PG(34:3) | 0.8640 | 0.8645 | 1.2715 | NA |
PG(36:1) | 1.4047 | 1.2314 | 1.2611 | 0.3271 |
PG(36:2) | 1.3419 | 1.2630 | 1.5831 | 0.1091 |
PG(36:3) | 0.9321 | 0.8714 | 1.1966 | NA |
PG(36:4) | 0.9989 | 1.0173 | 1.3058 | 0.0340 |
PG(36:5) | 0.9349 | 0.9472 | 1.1179 | NA |
PG(38:6) | 0.9057 | 0.9803 | 1.1140 | NA |
PG(40:5) | 1.1400 | 0.9407 | 0.9193 | NA |
PG(40:6) | 1.0235 | 0.9750 | 1.0015 | NA |
PG(54:0) | 1.0691 | 1.1588 | 0.7721 | NA |
Phaeantharine | 0.8227 | 0.9850 | 1.1923 | NA |
Phenolsulfonphthalein | 1.1574 | 1.0469 | 1.0744 | 0.7909 |
Phosphocreatine | 0.3835 | 0.4932 | 0.3442 | 2.3343 |
Phosphodimethylethanolamine | 1.2598 | 1.2025 | 0.8594 | 0.0348 |
Phosphoenolpyruvate | 0.7791 | 0.5552 | 0.5622 | 1.8276 |
Phosphoramidate | 0.6136 | 0.5369 | 0.4467 | 2.0520 |
[PI(16:0)] 1-hexadecanoyl-sn-glycero-3-phospho-(1^-myo-inositol) | 0.8585 | 1.0750 | 1.0665 | NA |
[PI(18:0)] 1-octadecanoyl-sn-glycero-3-phospho-(1^-myo-inositol) | 0.8995 | 1.1788 | 0.9217 | NA |
[PI(18:0/20:4)] 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1^-myo-inositol) | 1.0978 | 0.8131 | 0.7566 | 1.2494 |
PI(34:2) | 0.8746 | 0.7653 | 0.7330 | 1.4703 |
PI(36:1) | 1.5249 | 1.3756 | 1.2048 | 0.1710 |
PI(36:2) | 1.3120 | 1.2444 | 1.2256 | 0.4135 |
PI(36:3) | 1.1168 | 0.9893 | 1.0525 | 0.8811 |
PI(36:4) | 0.6613 | 0.6478 | 0.6145 | 1.8073 |
PI(38:5) | 1.1483 | 0.9849 | 0.8485 | 1.0137 |
PI(40:5) | 1.5201 | 1.2481 | 1.0354 | 0.3973 |
PIP(36:1) | 1.3045 | 1.1652 | 1.3063 | 0.4181 |
PS(18:0) | 0.7368 | 0.7255 | 0.8090 | 1.5465 |
PS(18:0/18:1(9Z)) | 1.4048 | 1.2234 | 1.1533 | 0.4140 |
[PS(18:1)] 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine | 1.3322 | 1.2295 | 1.0967 | 0.5061 |
[PS(20:4)] 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine | 0.7197 | 0.7295 | 0.5477 | 1.7523 |
PS(34:1) | 1.2956 | 1.3143 | 0.9604 | 0.5723 |
PS(34:2) | 1.4091 | 1.2039 | 0.8993 | 0.2316 |
PS(36:4) | 1.1837 | 1.1039 | 0.9118 | 0.8504 |
PS(38:4) | 0.6509 | 0.6042 | 0.4630 | 1.9614 |
PS(38:5) | 1.2139 | 0.9618 | 0.7219 | 1.0768 |
PS(38:6) | 1.0793 | 1.0265 | 0.7471 | 1.1103 |
PS(40:5) | 0.7348 | 0.6700 | 0.5082 | 1.8152 |
Psychosine | 0.2699 | 0.3908 | 0.4164 | 2.4421 |
Pyridoxine phosphate | 1.3189 | 0.9439 | 0.7672 | 0.9099 |
Raffinose | 0.3261 | 0.7310 | 0.3011 | 2.2313 |
(R,R)-Tartaric acid | 0.7294 | 0.6115 | 0.5507 | 1.8313 |
Sambutoxin | 0.8620 | 0.7264 | 0.9845 | 1.3204 |
Sanguinarine | 0.5288 | 0.5782 | 0.6005 | 1.9694 |
(S)-ATPA | 1.1259 | 1.6007 | 1.2525 | 0.2657 |
(S)-Dihydroorotate | 1.4672 | 1.2048 | 1.5281 | 0.0999 |
Ser-Ser-Ser | 1.0581 | 0.8764 | 0.9540 | 1.0836 |
Sinalbin | 1.0782 | 0.9016 | 1.0202 | NA |
(S)-Lactate | 0.6109 | 0.8091 | 0.9331 | 1.4851 |
(S)-Malate | 1.1039 | 0.8795 | 1.0100 | 1.0050 |
sn-glycero-3-Phosphoethanolamine | 0.6274 | 0.5250 | 0.5079 | 2.0047 |
sn-Glycerol 3-phosphate | 0.3306 | 0.3511 | 0.3062 | 2.5091 |
[SP (16:0)] N-(hexadecanoyl)-sphing-4-enine | 0.9463 | 0.7631 | 0.7519 | 1.4040 |
[SP] Sphing-4-enine-1-phosphate | 0.6950 | 0.5673 | 0.4897 | 1.8598 |
Succinyladenosine | 1.1890 | 1.0436 | 1.2794 | 0.4880 |
Sucrose monopalmitate | 0.9284 | 1.0857 | 0.6053 | 1.5707 |
Sulfate | 0.7100 | 0.5842 | 0.6757 | 1.7725 |
Sulfoacetaldehyde | 1.1611 | 1.1404 | 1.5041 | 0.3958 |
Taurine | 0.2843 | 0.3120 | 0.3291 | 2.5560 |
UDP-glucose | 1.1970 | 0.7880 | 0.7442 | 1.2031 |
UDP-glucuronate | 0.5275 | 0.3133 | 0.3598 | 2.3496 |
UDP-N-acetyl-D-galactosamine | 0.8367 | 0.8635 | 0.7756 | 1.3932 |
Val-Pro | 0.9108 | 1.0585 | 1.0307 | NA |
(Z)-4-Hydroxyphenylacetaldehyde-oxime | 0.7374 | 0.7027 | 0.6596 | 1.6752 |
Factors:
F1 | Artemisinin resistant:Resistant | PfKelch13 mutation:C580Y |
F2 | Artemisinin resistant:Resistant | PfKelch13 mutation:R539T |
F3 | Artemisinin resistant:Sensitive | PfKelch13 mutation:WT |
F4 | Artemisinin resistant:Uinfected red blood cells | PfKelch13 mutation:Control |