Metabolite_name RefMet_name G2.1 G2.2 G2.3 G2.4 G2.5 G2.6 G2.7 G2.8 G1.1 G1.2 G1.3 G1.4 G1.5 G1.6 G1.7 G1.8 Factors - Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Npm1-knockout Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type 2-Hydroxyglutaric acid 2-Hydroxyglutaric acid 228.3125 221.9584 236.7527 288.9175 299.9956 249.4886 283.1124 319.2852 353.5693 286.0528 272.1830 282.9775 239.4592 231.0206 424.7979 340.7256 2-Isopropylmalic acid 2-Isopropylmalic acid 2.5088 2.4471 2.4312 2.6418 2.5833 2.5355 1.9315 2.8190 0.9983 2.2248 1.3415 2.0265 1.6756 1.9535 2.6423 1.6630 3-Phosphoglyceric acid 3-Phosphoglyceric acid 1371.6905 1240.3732 1363.8763 964.2622 675.4229 714.2933 982.1174 891.5441 662.7169 602.8089 572.1526 524.7340 463.3086 635.6591 676.5986 506.1987 4-Hydroxyphenylpyruvic acid 4-Hydroxyphenylpyruvic acid 122.1228 98.0877 61.5219 41.6458 34.2725 49.4426 69.9158 76.3063 81.3248 96.2842 93.5640 84.3096 99.9894 94.1205 87.9420 91.0897 6-Phosphogluconic acid 6-Phosphogluconic acid 2089.8054 1126.1680 2045.7738 1550.9400 1189.8207 618.0880 698.8019 654.9214 240.5202 118.5075 94.9476 96.2572 208.6747 299.7346 61.1906 29.9938 Adenosine diphosphate ADP 246.5635 150.6115 158.5773 210.3190 230.9646 154.7419 208.1178 176.8085 2114.2844 36.3303 22.5604 1305.4709 1001.8374 27.0865 2846.8193 768.7548 Adenosine triphosphate ATP 29.3843 16.8140 18.3559 29.5709 52.6108 11.5543 19.5166 13.1689 1151.3443 451.2420 306.6886 32.6418 955.1010 383.8435 alpha-Ketoglutaric acid 2-Oxoglutaric acid 104.7069 227.8293 324.8938 427.5780 161.9903 226.5613 310.6725 105.3286 46.9664 42.6908 28.3174 22.2689 30.4687 17.7156 24.6566 54.2128 alpha-Ketoisovaleric acid Ketoisovaleric acid 56.8181 67.3241 153.3764 115.7875 73.5598 86.6118 69.8070 56.4826 25.3635 22.2549 16.6781 17.1089 18.3356 15.8638 16.7583 18.6026 cis-Aconitic acid cis-Aconitic acid 44.1869 47.0809 42.9281 48.7702 63.2198 41.3403 47.4806 62.9511 142.7259 78.0736 59.3556 61.8855 60.2173 73.6429 54.8706 67.2949 Citric acid Citric acid 1470.1378 1822.0399 1617.5945 1797.2152 2019.1037 1612.5703 2045.6756 2598.7758 10861.0682 6320.0283 5254.9558 5318.3068 5790.5896 5948.6848 4920.3278 5889.8297 Cyclic 3^_5^-AMP 3',5' cyclic AMP 1.1271 0.5600 0.5886 0.8729 0.9187 0.7733 0.7751 0.8256 2.4274 2.7002 1.7547 2.8272 2.0635 1.4765 3.1914 2.3114 Cysteic acid Cysteic acid 22.4449 29.5917 26.2066 19.6210 20.0269 17.4469 22.9510 21.1251 23.6559 34.7777 24.7695 19.9886 38.2222 36.5195 27.8332 22.1510 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 3.9477 2.1303 1.7204 3.0161 2.8780 2.1219 1.2110 2.4550 108.8036 5.2318 1.5177 8.4796 44.4509 52.8169 Erythrose 4-phosphate Erythrose 4-phosphate 2188.5423 1250.5061 2124.9831 1591.6806 1220.9547 736.7873 803.2817 775.5217 164.9559 90.2959 82.6681 77.0107 152.3298 203.9691 Flavine-adenine dinucleotide FAD 53.8187 42.2709 41.6215 47.5483 50.8397 28.5518 38.9980 33.0666 21.0192 75.7923 36.1609 43.9428 68.7633 29.2305 67.9366 61.2197 Flavin mononucleotide FMN 11.5971 20.5167 27.3511 26.9920 11.0036 28.4823 24.8249 23.2829 204.2083 104.1225 141.7160 141.9549 63.9606 118.4974 75.5057 76.8903 Fructose 1_6-bisphosphate Fructose 1,6-bisphosphate 94.0667 87.1031 83.7072 96.0352 94.6192 83.9395 67.5652 100.1152 611.1761 36.5929 14.3088 49.9651 12.2116 251.5420 304.5605 Fructose 6-phosphate Fructose 6-phosphate 654.2762 548.4679 609.4765 370.8632 304.0656 571.3849 408.0287 674.0642 155.4178 141.2560 105.9804 77.4617 120.2498 113.6612 61.2175 48.2232 Fumaric acid Fumaric acid 1101.3975 957.8691 919.5849 951.0395 886.1095 1190.9899 912.0767 1083.7596 960.3341 795.7878 746.7286 768.1022 682.6518 692.1097 633.1991 647.9366 Glucaric acid Glucaric acid 14.8301 16.5660 17.7126 14.9314 14.2365 13.8842 16.0367 18.6795 16.1896 19.0524 14.2380 14.0773 15.1822 14.8865 12.8165 12.5615 Gluconic acid Gluconic acid 163.0151 190.3152 175.7770 204.2375 210.7862 145.1067 173.1578 175.5066 329.6730 275.7366 276.7596 287.3227 184.4940 186.7567 329.3478 348.3432 Glucose 6-phosphate Glucose 6-phosphate 3261.8056 2202.4623 2668.5653 1544.4360 1369.5357 2613.5163 1519.9425 2947.5319 638.6939 283.9010 276.5219 255.6350 187.3360 282.0996 217.8612 117.3323 Glucuronic acid Glucuronic acid 14.3474 19.6951 18.6511 18.2496 22.3836 18.7394 20.3367 24.5062 34.5341 36.7661 30.1761 26.0374 29.1717 31.1411 29.9937 30.0999 Glyceric acid Glyceric acid 318.3611 276.2499 299.8092 369.4889 488.0762 312.6117 178.3615 372.3992 67.9699 52.1617 59.4346 49.9286 41.6891 46.0618 49.9907 50.2578 Glycerol 3-phosphate sn-Glycero-3-phosphate 756.5621 600.4179 549.0118 450.4659 432.8545 346.0969 565.6869 395.9758 658.4046 705.4618 699.2583 623.0087 672.6558 749.4982 364.1014 332.7196 Glycolic acid Glycolic acid 207.0821 176.7925 173.3682 225.9545 233.6445 187.0016 142.6359 232.1491 59.3274 48.4043 44.4549 33.0598 38.3287 42.4541 49.3488 57.6214 Glyoxylic acid Glyoxylic acid 17.0408 21.7965 13.2170 16.7491 17.8733 14.9442 13.0311 23.6537 49.6649 91.3036 70.2327 62.3456 67.1012 60.5451 61.4995 74.2928 Guanosine diphosphate GDP 135.8406 62.3017 101.9952 91.8184 64.9002 69.8500 110.2556 66.6754 800.4947 221.1242 378.4703 664.5608 454.1669 161.9173 659.9578 710.1088 Guanosine triphosphate GTP 17.0578 8.4040 11.4973 19.3027 16.9906 8.1455 9.5882 8.9546 507.5304 41.1526 55.2570 241.9402 147.3307 53.1318 326.8326 430.6616 Hippuric acid Hippuric acid 115.6509 94.4446 56.7416 37.1446 32.3259 46.3904 62.4571 72.5856 84.8911 94.0458 92.5769 87.3919 93.7361 91.9847 79.0267 91.0520 Homogentisic acid Homogentisic acid 30.5062 34.4465 27.7798 20.0606 16.8987 23.2153 26.1269 29.1119 52.1527 54.9558 52.2500 49.6557 55.1293 55.5065 56.3844 57.9474 Indoleacetic acid Indoleacetic acid 44.7557 48.5910 43.4698 50.5244 63.2692 40.4690 46.7224 65.1321 142.3937 79.4325 61.2998 63.4183 60.5038 73.2724 54.6499 67.5647 L-Lactic acid Lactic acid 17102.2745 14433.6516 15865.3872 13853.3371 13542.3556 16384.4710 12177.2579 17099.5467 25065.2783 24975.2369 23473.9912 22571.7217 20923.2448 20671.1937 17124.5467 19895.4937 Maleic acid Maleic acid 6.6404 6.3520 6.9371 6.3284 6.0999 4.9691 4.1964 7.4797 6.3965 6.0011 5.3862 5.8189 3.9728 5.7844 4.8998 4.2800 Malic acid Malic acid 4024.2596 3586.6583 3568.8990 4202.0862 4091.8508 4594.2231 3198.2579 4494.1830 3704.6210 2850.2124 2190.4226 2360.8063 2299.4184 2281.1574 3131.5235 2502.9970 Mannose 6-phosphate Mannose 6-phosphate 436.3182 372.0532 458.7580 143.7808 86.4580 335.3812 261.3273 376.2002 126.0992 101.2012 87.3370 87.5443 83.9294 104.4607 66.0901 56.4622 Methylmalonic acid Methylmalonic acid 12.1497 21.7805 25.0451 16.8327 15.4682 18.7934 28.3055 35.4435 16.5233 20.9934 16.9537 16.2643 18.0680 19.4372 112.4473 67.8050 Mevalonic acid Mevalonic acid 0.2790 0.3477 0.3447 0.2100 0.1912 0.4053 0.4165 0.3871 0.4869 0.3891 0.5372 0.3247 0.4581 0.3971 0.2896 0.4133 Orotic acid Orotic acid 7.1320 6.4391 6.5978 7.8577 8.8645 8.0213 4.7629 8.2684 27.1092 17.5276 9.5633 10.0463 15.0174 13.5444 7.8337 10.6292 Phosphoenolpyruvic acid Phosphoenolpyruvic acid 809.0014 710.3424 900.9907 384.5843 161.3744 244.4300 549.8649 329.6930 91.9146 122.9447 200.3336 142.7971 43.9814 153.5757 263.7706 121.0941 Picolinic acid Picolinic acid 28.2498 30.7273 25.7148 17.8784 17.1687 20.1607 23.0638 26.6257 47.1752 52.5965 49.8011 46.6176 54.9100 56.7066 53.2110 52.8439 Pyruvic acid Pyruvic acid 950.3275 2303.6480 2346.9259 2474.7288 975.2839 1699.8156 1674.1174 2720.3211 429.7340 886.8944 427.4142 176.1382 206.1186 256.0929 168.9690 133.7453 Quinolinic acid Quinolinic acid 29.8447 33.8710 26.9962 20.4270 18.3935 20.3024 26.2448 28.5874 49.5950 53.8019 50.3754 49.3089 55.2053 55.9735 54.3404 55.9845 Ribose 5-phosphate Ribose 5-phosphate 559.0288 560.8130 431.5947 828.0001 356.9020 684.2616 421.3240 660.3010 159.8150 574.4249 500.8731 282.7686 188.7010 194.9397 400.7963 281.4640 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 480.4240 405.3777 458.8148 435.3916 345.3297 457.6058 655.4205 459.7638 101.8684 523.3882 242.4552 216.5095 160.0632 98.9931 304.5773 309.1524 Succinic acid Succinic acid 692.4150 1256.8984 1443.5015 1302.6651 1328.1758 1400.0754 1883.6997 1798.9628 3674.6015 4433.5712 4374.1382 4265.9666 3583.3951 3650.1083 7553.2473 5872.1308 Ureidopropionic acid Ureidopropionic acid 7.9583 5.4267 6.5717 6.9897 10.9037 5.7321 2.8822 5.2283 2.0469 2.3815 2.7177 2.6704 1.5244 1.2909 2.1819 1.7134