Metabolite_name	RefMet_name	185S0	185S1	185S14	185S18	185S7	188S0	188S1	188S14	188S18	188S7	908S0	908S1	908S14	908S18	908S7	909S0	909S1	909S14	909S18	909S7	081S0	081S1	081S14	081S18	081S7	107S0	107S1	107S14	107S18	107S7	120S0	120S1	120S14	120S18	120S7	122S0	122S1	122S14	122S18	122S7	180S0	180S1	180S14	180S18	180S7	907S0	907S1	907S14	907S18	907S7
Factors	-	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:control	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention	Sample source:fecal | Factor:intervention
12-ketoLCA	12-Ketolithocholic acid	53.7278	42.5963	62.8800	26.3241	43.2669	126.5720	101.9639	53.2800	84.8485	37.2908	58.2107	83.0952	41.5842	57.5806	94.7879	80.8065	75.6627	66.6932	24.3863	31.7787	86.4097	78.1065	85.7831	89.0551	20.1939	23.4623	46.4822	18.0478	26.0446	24.2915	48.9505	87.1006	26.9291	88.8791	46.9355	65.7201	25.2883	20.4970	23.3939	130.5882	82.5152	110.3150	29.2216	71.6633	76.9355	80.7229	72.7634	62.8235	46.1167	51.9115
"6_7-diketoLCA"	6,7-Diketolithocholic acid	0.1527	0.1950	0.2616	0.0609	0.1551	0.3383	0.3487	0.1637	0.1464	0.1716	0.3054	0.2714	0.1148	0.1911	0.4291	0.5032	0.3590	0.3944	0.1077	0.0714	0.2412	0.2793	0.7060	0.3945	0.1396	0.1151	0.1852	0.0662	0.0718	0.0821	0.2124	0.3740	0.1644	0.3191	0.0905	0.2376	0.2324	0.1995	0.3855	0.4353	0.1519	0.3118	0.1250	0.2886	0.2257	0.3157	0.3125	0.3200	0.1376	0.1874
"7_12-diketoLCA"	7,12-Diketolithocholic acid	2.2722	2.6288	1.8120	1.7621	2.2231	1.5383	1.4285	3.2160	1.7164	1.2000	2.9583	2.3381	1.6016	1.8629	1.9758	2.8548	3.9036	2.3833	1.4632	1.6292	2.2637	2.2130	3.3012	1.5780	2.5697	2.1214	2.2791	1.7307	1.8207	1.7636	2.3002	2.4615	1.5142	2.9670	3.5081	2.5801	1.8203	1.5645	1.1442	2.7059	1.9132	2.7402	1.4204	2.1884	1.9548	2.1349	2.9821	2.6588	2.0113	2.2817
7-ketoLCA	7-Ketolithocholic acid	0.5018	1.5067	0.9648	0.3439	0.8080	1.1781	0.6084	0.8544	1.4109	0.5092	0.6322	2.9286	0.1994	1.3573	1.5709	4.4758	9.6867	2.8446	0.7099	0.7708	0.9542	3.1479	3.8554	0.6591	0.3345	0.7576	0.9296	0.2653	0.2081	0.7749	0.7224	2.9586	1.2331	4.0879	3.9194	0.8763	0.7944	0.8189	1.0085	4.6588	0.3554	3.2835	0.4168	1.5896	1.3161	1.6578	1.3861	1.7247	0.4394	0.9682
ACA	Allocholic acid	6.9586	8.3245	14.2800	10.0553	11.5697	35.0507	17.7234	13.5840	13.9152	10.8526	26.9583	14.3810	21.2436	14.0806	17.1636	29.7581	9.4940	22.2072	9.9960	6.2372	14.7018	13.9172	24.8193	18.5906	15.3455	5.2301	6.4032	10.1116	19.9838	10.2996	9.7426	22.3905	37.7953	57.4945	11.7581	17.1116	14.9105	13.8698	29.0909	20.3765	9.7850	11.5512	9.8922	25.9719	13.2339	21.0843	20.5408	16.0235	14.1730	14.9457
alloLCA	Allolithocholic acid	0.3574	0.3797	0.1918	0.1352	0.2027	0.5647	0.2766	0.5760	0.1658	0.2307	0.7586	0.2643	0.1839	0.1781	0.1733	0.4815	0.2819	0.2211	0.2019	0.1174	0.2824	0.3882	0.2699	0.2717	0.2667	0.1933	0.2289	0.1489	0.1779	0.2317	0.3659	0.3905	0.2669	0.6369	0.1544	0.4771	0.1668	0.2047	0.3345	0.4776	0.3383	0.3685	0.1593	0.2393	0.3290	0.2383	0.2252	0.1598	0.1490	0.2006
alpha-MCA	alpha-Muricholic acid	38.3432	33.5903	42	15.0593	38.9641	93.9554	42.5651	38.6400	22.8364	24.6215	65.6064	33.3333	27.0891	23.2500	48.7273	88.5484	48.6747	48.2869	14.0523	26.0870	49.8986	44.7337	52.7711	31.8898	42.1818	31.0387	26.5613	15.4183	21.7120	37.4089	38.7327	54.6746	53.6220	64.4835	42.3387	55.4970	43.1809	25.3254	39.2727	62.1176	48.1947	36.3780	20.5988	47.8557	52.0161	45.7831	40.3181	35.7647	20.3058	49.9799
beta-MCA	beta-Muricholic acid	154.5562	153.8337	169.2000	139.4466	164.4622	214.4422	175.3106	169.2000	147.8788	134.8207	198.9662	156.9048	169.4257	155.3226	174.7879	198.1452	149.6386	180.4781	120.2414	121.1858	172.5761	177.9882	197.3494	179.7638	153.9394	130.2648	147.5099	114.9801	158.4584	155.2227	164.1980	186.0355	181.6535	545.9341	156.5323	173.7931	170.8151	154.3195	191.2727	177.8824	166.9777	155.1969	137.0060	185.4108	156.7742	177.5904	174.8708	176.4706	145.1107	168.5312
beta-UDCA	Isoursodeoxycholic acid	0.4189	0.3724	0.8184		0.2438	1.7258	0.3824	0.2054	0.4097	0.3371	1.3551	0.3381	0.1777	0.3435	1.1758	1.6306	1.2506	0.7482	0.1041	0.1010	0.8349	0.6130	1.6313	0.8244	0.0992	0.1095	0.2353		0.1271	0.1839	0.2229	0.6059	0.7724	0.8374	0.4016	0.7424	0.6608	0.3101	0.4994	1.2071	0.2653	0.5528	0.1334	0.7022	0.7573	0.2747	0.4461	0.8824	0.1598	0.4612
CA	Cholic acid	3.5740	6.3286	5.8560	1.1597	2.7729	5.2089	5.4830	2.7360	9.2606	8.2231	8.0636	15.0238	2.2764	9.9435	14.6667	46.4516	24.8193	28.6853	6.3260	3.8419	11.5862	8.4024	35.4217	9.4724	2.4485	2.7617	4.2213	1.1307	2.8235	9.0364	7.8653	27.9290	13.9370	68.1758	22.6452	8.7140	13.6700	12.2840	57.9394	15.2471	2.0592	11.5276	3.0180	16.7375	6.3387	8.9398	17.1531	30.8235	5.0463	6.4225
CDCA	Chenodeoxycholic acid	1.7538	3.4807	1.4808	0.8775	1.4295	1.7063	1.1808	1.4400	1.8667	0.9562	1.9014	6.1905	0.6986	2.0032	2.3370	9.4355	11.6386	4.1833	3.0905	2.6324	2.0373	3.9527	5.2771	1.5969	1.1758	1.8868	1.4158	0.6813	0.4114	4.2753	2.5188	6.8166	5.2913	6.1978	2.9032	2.3562	4.7475	3.5266	8.3879	4.9412	0.7716	3.1417	1.4060	4.4008	5.5403	2.1639	2.8628	4.4706	1.2145	1.8085
DCA	Deoxycholic acid	46.6272	41.1359	42.7200	28.2213	47.3307	84.2191	63.2465	52.0800	45.8182	43.0279	75.6262	46.9048	55.1287	37.9839	49.9394	69.1935	50.8434	54.9801	36.9416	26.7984	59.8783	49.2308	55.4217	52.2047	38.0606	28.5947	35.3360	25.0996	39.9189	46.3968	55.8416	66.2722	66.8504	175.3846	47.9032	62.5558	65.3678	46.1538	61.8182	53.1765	51.3590	52.4409	26.8263	55.3106	60.9677	68.9157	55.8250	46.3529	39.3561	58.1891
DHCA	Dehydrocholic acid	0.0237	0.0903	0.0379			0.0304	0.0455	0.0418	0.1726	0.0753		0.0883		0.1619	0.2160	0.1311	0.5133	0.1506		0.1513	0.0504	0.1096	0.3012	0.0772		0.0276	0.1048				0.0285	0.0914		0.2400	0.3315	0.0256	0.0193	0.0237	0.0229	0.3294	0.0333	0.3472	0.0251	0.0741	0.0244	0.0323	0.1820	0.1593	0.0231	0.0204
GCA	Glycocholic acid	0.0400	0.0689	0.0506	0.0164	0.0516	0.0358	0.0284	0.0696	0.0419	0.0564	0.0396	0.0636	0.0366	0.0641	0.1682	0.2419	0.3108	0.3753	0.0454	0.0375	0.0613	0.0516	0.2164	0.0591	0.0315	0.0249	0.0422	0.0198	0.0240	0.0979	0.0665	0.1735	0.0335	0.1116	0.0503	0.0467	0.1155	0.1191	0.1457	0.2965	0.0235	0.0999	0.0335	0.0500	0.0419	0.0892	0.0561	0.1127	0.0244	0.0401
GCDCA	Glycochenodeoxycholic acid	0.0116	0.0138	0.0128	0.0101	0.0151	0.0111	0.0129	0.0141	0.0152	0.0136	0.0111	0.0159	0.0113	0.0122	0.0252	0.0261	0.0390	0.0325	0.0160	0.0167	0.0140	0.0159	0.0313	0.0129	0.0111	0.0127	0.0130	0.0098	0.0101	0.0158	0.0123	0.0232	0.0146	0.0559	0.0136	0.0107	0.0155	0.0205	0.0187	0.0282	0.0114	0.0167	0.0121	0.0137	0.0179	0.0136	0.0143	0.0180	0.0101	0.0141
GDCA	Glycodeoxycholic acid	0.0596	0.0545	0.0749	0.0382	0.0708	0.1383	0.1390	0.2592	0.0844	0.0576	0.1579	0.1026	0.1454	0.0738	0.1345	0.1161	0.1157	0.1716	0.0734	0.0496	0.1105	0.0620	0.1087	0.1165	0.0509	0.0359	0.0583	0.0375	0.0448	0.0595	0.0549	0.1512	0.1807	0.2664	0.0864	0.1081	0.0890	0.0646	0.1976	0.1115	0.0876	0.1013	0.0402	0.0681	0.0965	0.1280	0.1112	0.0953	0.0514	0.1198
GHDCA	Glycohyodeoxycholic acid		0.0068	0.0074		0.0192	0.0085	0.0118	0.0120	0.0100	0.0075	0.0042	0.0091	0.0117	0.0043	0.0301	0.0605	0.0501			0.0075	0.0078	0.0148	0.0386	0.0120			0.0027			0.0035		0.0123	0.0064		0.0064		0.0032	0.0253	0.0199	0.0541	0.0055	0.0257			0.0083	0.0103	0.0109			0.0151
GLCA	Glycolithocholic acid	0.0956	0.1013	0.0996	0.0918	0.0997	0.1161	0.1113	0.1387	0.0987	0.0956	0.1074	0.1193	0.1041	0.0958	0.1115	0.1055	0.1186	0.1033	0.0995	0.0987	0.1064	0.1011	0.1072	0.1006	0.0975	0.0973	0.0989	0.0925	0.0935	0.0991	0.0943	0.1020	0.1042	0.5064	0.0997	0.1030	0.0973	0.0954	0.1033	0.1292	0.1049	0.1042	0.0941	0.0950	0.1132	0.1219	0.0995	0.0976	0.0954	0.1123
GUDCA	Glycoursodeoxycholic acid	0.0106	0.0102	0.0116	0.0073	0.0096	0.0112	0.0102	0.0153	0.0099	0.0161	0.0151	0.0150		0.0118	0.0262	0.0215	0.0226	0.0418	0.0093	0.0086	0.0155	0.0100	0.0492	0.0156		0.0079	0.0100			0.0113	0.0100	0.0164	0.0147		0.0129	0.0107	0.0131	0.0138	0.0231	0.0318	0.0092	0.0137		0.0103	0.0119	0.0123	0.0124	0.0282		0.0124
HDCA	Hyodeoxycholic acid	3.3136	3.2373	4.2720	1.7597	5.7371	13.5091	9.3307	5.1600	4	9.9681	7.1809	2.9048	7.9366	2.0540	3.9273	9.4355	4.2169	2.4861	1.4439	3.2490	5.3550	5.6095	9.0843	6.5433	3.2242	1.6815	1.9186	1.3936	2.0933	4.1296	2.6139	6.3195	11.8110	10.1670	4.1129	3.8215	4.1034	5.4911	11.3939	6.9412	6.4990	5.1260	1.3581	2.0345	8.4435	7.3012	6.0119	2.5412	1.6419	8.1368
isoLCA	Isolithocholic acid	4.4970	4.2110	2.1576	0.7399	2.2614	14.5071	4.6653	7.8000	1.3552	2.0343	6.3459	1.9190	2.2479	1.0282	2.6424	6.9435	3.8554	1.8311	1.7119	1.0245	4.1379	4.6391	2.8434	2.2913	3.2727	3.2994	2.3621	0.7339	0.9030	2.6478	4.3723	4.1657	3.5197	4.5758	1.8532	8.4949	2.7674	1.5550	2.3273	10	4.6734	4.1102	1.1353	1.4790	5.8306	3.6386	1.7606	1.1906	1.1590	2.9698
LCA	Lithocholic acid	50.8876	41.6227	23.5680	8.9407	26.7729	152.3732	69.2585	74.8800	16.5818	27.9681	96.8588	49.0476	26.1386	12.7984	37.0909	79.1129	50.3614	26.2948	22.3581	12.4032	53.3063	54.9112	36.8675	28.5827	36.8485	32.7495	27.9842	8.6295	9.7120	30.8502	47.5248	49.4675	42.9921	46.8132	22.9113	65.2333	33.3996	22.4379	28.8485	99.7647	43.3266	44.8819	14.2036	19.2144	64.3548	78.0723	29.1054	19.6235	15.2596	39.8390
LCA-3S	Lithocholic acid sulfate	0.2840	0.4892	0.5736	0.6142	0.4685		0.3824	0.3648	0.6400	0.5928		0.3071	0.4040	0.4597	0.9358	0.3048	1.2699	1.1594	1.0503	0.4909	0.4333	0.2722	0.6651	0.4984	0.3273	0.4057	0.3344	0.4470	0.3675	0.4785	0.3350	0.3408	0.4299	2.3473	0.4960	0.2921	0.2839	0.3976	0.4970	0.5812	0.3043	0.2835	0.3138	0.4160	0.3000	0.3422	0.3316	0.7247	0.5288	0.5602
NorCA	Norcholic acid	2.9822	1.7744	14.4960	2.2364	2.0845	0.9055	0.9715	5.9280	6.0848	3.5139	4.2942	3.9762	10.7168	8.3468	10.6909	4.1613	2.2096	11.9761	3.9115	0.9202	2.8722	3.5503	23.3735	8.9764	7.4667	0.9703	1.1099	2.9163	9.4442	3.9595	2.2147	2.0308	30	7.1868	2.7097	4.1136	2.3666	7.2899	7.9758	3.0118	0.3895	0.5457	5.7246	12.2645	2.7823	3.7831	2.8151	25.6471	9.1026	6.7364
NorDCA	23-Nordeoxycholic acid	0.3787	0.2028	0.4680	0.5810	0.2462	0.2176	0.2044	0.6576	0.4679	0.2558	0.2863	0.2248	0.9149	0.5758	0.3782	0.3484	0.2094	1.0040	0.5022	0.2632	0.2604	0.1711	0.7373	0.7039	0.2909	0.1198	0.1150	0.4494	0.7619	0.3328	0.3802	0.2014	1.2543	1.8725	0.2879	0.2108	0.1637	0.5799	0.7952	0.1741	0.1288	0.0817	0.3832	0.7070	0.1381	0.5422	0.3936	0.8094	0.6736	0.5070
T-alpha-MCA	Tauro-alpha-muricholic acid	0.4805	0.6645	0.4752	0.1862	0.5904	0.6840	0.5387	0.6648	0.2812	0.4231	0.4676	0.4762	0.2274	0.6145	0.9915	3.0242	0.9566	1.4892	0.5191	0.7921	0.5477	0.8118	0.7253	0.3827	0.4436	0.8310	0.6854	0.3490	0.3943	0.8308	0.6392	1.8225	0.8929	0.9284	0.6411	0.6888	0.8660	0.8521	0.5333	1.0729	0.3773	0.9520	0.3257	0.7214	0.8927	0.7663	0.6823	0.6235	0.2608	0.6278
T-beta-MCA	Tauro-beta-muricholic acid	5.7988	6.4260	6.3840	4.6245	4.9960	7.1318	5.0261	7.1520	4.5091	4.0637	7.2286	6.7857	4.3248	14.1774	11.3455	40.8871	5.8795	19.8167	9.8511	5.3123	7.7890	8.5207	13.5422	11.0787	3.4424	6.3299	7.2806	5.3068	9.4929	6.4372	9.1248	19.3609	11.3386	14.3736	4.9113	6.7911	10.7117	15.9527	10.6424	11.3176	3.1400	11.0079	4.7904	13.0822	5.9274	11.1084	8.1352	13.5765	7.5815	4.5634
TCA	Taurocholic acid	1.1077	1.8791	0.8424	0.8893	1.3195	1.7355	1.2240	1.1376	1.0933	0.7339	1.2954	1.0571	0.8269	2.0347	1.1806	5.8548	1.8410	1.2717	2.3324	2.5850	1.4361	1.9219	1.0265	1.1929	0.5794	1.4420	1.9731	0.9442	1.4775	1.4866	1.7038	3.9290	2.1638	2.7165	1.0960	1.6990	2.0994	2.1680	1.1248	1.5365	0.8690	2.9528	1.4802	2.3687	1.2847	2.3373	1.9753	0.9671	0.8089	0.9247
TCDCA	Taurochenodeoxycholic acid	4.6627	2.2296	0.6456	1.1289	6.4542	0.9712	0.7022	0.7344	2.4970	2.7251	0.3960	1.2762	0.5560	1.6911	1.9030	2.0903	2.5542	0.7960	13.8350	10.8379	0.6207	1.1124	0.6145	0.5953	0.6739	1.3491	0.8538	0.4733	0.2604	4.6397	1.4210	1.6876	6.7087	1.0312	0.5250	0.6523	1.0807	2.2320	0.4000	1.2635	0.4308	3.0709	3.8802	7.3828	5.6371	0.9735	2.6720	0.8847	0.3718	0.7437
TDCA	Taurodeoxycholic acid	0.1157	0.1706	0.1598	0.0716	0.1480	0.3213	0.1955	0.1927	0.1299	0.1516	0.1782	0.1681	0.1179	0.1938	0.3345	0.6097	0.2145	0.9418	0.1490	0.2172	0.3237	0.2078	0.1923	0.2060	0.1159	0.1476	0.1674	0.1083	0.1317	0.1513	0.2371	0.6462	0.2717	0.5130	0.2412	0.2164	0.2815	0.3763	0.3636	0.1979	0.1784	0.3283	0.1030	0.2325	0.2323	0.2916	0.2839	0.1536	0.1055	0.1717
THDCA+TUDCA	Taurohyodeoxycholic acid	0.1818	0.2047	0.2076	0.0996	0.1489	0.2359	0.1878	0.2100	0.1239	0.1645	0.2433	0.2233	0.1098	0.3677	0.3515	0.9847	0.2506	0.4279	0.2414	0.2243	0.2677	0.2580	0.4120	0.2929	0.1050	0.1862	0.2298	0.1320	0.1894	0.2062	0.2179	0.4450	0.3850	0.2914	0.1759	0.2037	0.3125	0.4260	0.2521	0.3435	0.1305	0.4134	0.1693	0.3463	0.2359	0.3181	0.2328	0.3647	0.1480	0.1562
TLCA	Taurolithocholic acid	0.0480	0.0609	0.0521		0.0459	0.0613	0.0500	0.0674			0.0468	0.0576			0.0802	0.1055	0.0783	0.1315	0.0519	0.0669	0.0516	0.0559	0.0576	0.0487		0.0479	0.0503			0.0617	0.0461	0.0937	0.0669	0.2308	0.0752	0.0567	0.0544	0.0615	0.0572	0.0772	0.0509	0.0702		0.0479	0.0810	0.0660	0.0525	0.0522		0.0563
UCA	Ursocholic acid	0.6059	0.4722	0.6336	0.7518	0.3801	1.2633	0.4810	0.4992	0.6521	0.4614	1.2310	0.3738	0.7533	0.7282	0.6521	1.4347	0.6554	0.9203	0.6060	0.2988	1.2414	0.9065	1.1325	1.0654	0.7442	0.3764	0.5336	0.3992	1.0710	0.6874	0.6725	1.1195	2.0291	2.6374	0.8250	1.3363	1.0807	0.6580	1.0909	0.9553	0.5501	0.7181	0.5437	1.2000	0.5492	0.2819	0.5201	0.8729	1.0406	0.6592