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MB Sample ID: SA042887
Local Sample ID: | CMC2014-0 |
Subject ID: | SU000808 |
Subject Type: | Human |
Subject Species: | Homo sapiens |
Taxonomy ID: | 9606 |
Age Or Age Range: | 39-93 years |
Weight Or Weight Range: | 55-130 KG |
Gender: | males and females |
Human Race: | Caucasian (C) and African American (AA) |
Human Inclusion Criteria: | Suspicion of or confirmed infection; two or more systemic infmammatory response syndrome criteria; hypotension requiring vasopressors despite volume resuscitation; a cumulative vasopressor index of 3 or more after 4 hours of administration; and a SOFA score of at least 5. |
Human Exclusion Criteria: | Age less than 18; greater than 16h after septic shock recognition; a Do Not Resuscitate order; or known inborn error of metaboloism. |
Species Group: | Human |
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Treatment:
Treatment ID: | TR000822 |
Treatment Summary: | Intravenous carnitine |
Treatment Protocol Comments: | Non-treatment group: equivalent volume of saline placebo |
Treatment Compound: | L-carnitine |
Treatment Route: | 4g bolus followed by an 8g infusion over 12h |
Treatment Dose: | 12g |
Treatment Doseduration: | 12h (following initial 4g bolus) |