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MB Sample ID: SA322072
Local Sample ID: | 234-3856_brain |
Subject ID: | SU003071 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
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Treatment:
Treatment ID: | TR003080 |
Treatment Summary: | Plp1-iCKO-Myrf mice were randomly assigned into the control or Sob-AM2 treatment groups. Both Cre negative mice, which do not lose Myrf and undergo demyelination, and Cre positive mice, which do undergo demyelination, were used in all experiments. The control group received control chow (Envigo Teklad 2016 diet) and the Sob-AM2 treatment group received chow containing 420 µg/kg chow of Sob-AM2 (nominal daily dose of 84 µg/kg body weight) starting 2 weeks after tamoxifen injections. Mice on control chow were euthanized at 4 timepoints: 6, 12, 18, and 24 weeks post-tamoxifen injections. Mice treated with Sob-AM2 were euthanized at 12 and 18 weeks post-tamoxifen. |