metabolite_name 2019_09_13_RPIP15_Blank_mid6 2019_09_13_RPIP15_Blank_mid7 2019_09_13_RPIP15_Blank_mid8 2019_09_13_RPIP15_Blank_mid9 2019_09_13_RPIP15_Blank_mid10 2019_09_13_RPIP15_H1-M1_1 2019_09_13_RPIP15_H1-M1_2 2019_09_13_RPIP15_H1-M2_1 2019_09_13_RPIP15_H1-M2_2 2019_09_13_RPIP15_H1-M3_1 2019_09_13_RPIP15_H1-M3_2 2019_09_13_RPIP15_H1-M4_1 2019_09_13_RPIP15_H1-M4_2 2019_09_13_RPIP15_H1-M5_1 2019_09_13_RPIP15_H1-M5_2 2019_09_13_RPIP15_H9-naive-bioreactor-1- 2019_09_13_RPIP15_H9-naive-bioreactor-2 2019_09_13_RPIP15_H9-naive-bioreactor-3 2019_09_13_RPIP15_H9-primed-bioreactor-1 2019_09_13_RPIP15_H9-primed-bioreactor-2 2019_09_13_RPIP15_H9-primed-bioreactor-3 2019_09_13_RPIP15_Ref-Media-H1-M1_1 2019_09_13_RPIP15_Ref-Media-H1-M1_2 2019_09_13_RPIP15_Ref-Media-H1-M2_1 2019_09_13_RPIP15_Ref-Media-H1-M2_2 2019_09_13_RPIP15_Ref-Media-H1-M3_1 2019_09_13_RPIP15_Ref-Media-H1-M3_2 2019_09_13_RPIP15_Ref-Media-H1-M4_1 2019_09_13_RPIP15_Ref-Media-H1-M4_2 2019_09_13_RPIP15_Ref-Media-H1-M5_1 2019_09_13_RPIP15_Ref-Media-H1-M5_2 2019_09_13_RPIP15_Ref-Media-H9-naive-bioreactor-1 2019_09_13_RPIP15_Ref-Media-H9-naive-bioreactor-2 2019_09_13_RPIP15_Ref-Media-H9-naive-bioreactor-3 2019_09_13_RPIP15_Ref-Media-H9-primed-bioreactor-1 2019_09_13_RPIP15_Ref-Media-H9-primed-bioreactor-2 2019_09_13_RPIP15_Ref-Media-H9-primed-bioreactor-3 Pyruvate 19130.54 13694.65 15617.58 9440.81 14266.6 182114.83 153551.5 175914.45 142518.55 183612.69 163362.08 204710.05 207015.23 270089.25 204316.86 103718.54 189152.64 138419.66 99691.62 139186.45 115717.85 145343.23 127989.41 181817.05 180480.73 173681.59 168964.22 218358.3 203979.38 274755.53 237808.42 260657.75 290514.28 228701.52 225358.33 190077.12 195382.58 L-Alanine 2450.7 3066.22 3293.82 4731.79 2575.05 339421.34 236446.05 519150.84 473889.38 780970 903638.5 1470821.12 1370521.62 1947808.5 1957785.38 2113074.75 1946130.12 2243909.25 374749.91 357588.28 472814.38 47140.23 73707.6 106757.62 73674.2 76306.73 82949.48 91190.56 101064.65 92815.15 79686.85 67422.3 79448.29 56659.71 86660.25 84800.91 75427.91 lactate 35038.45 34709.1 54222.32 38128.69 59305.89 39271008 35160632 16831590 18496208 13251512 13463163 12882235 13242920 9562433 9238140 80045408 75418624 70192648 63984236 73691592 74447072 48745.69 45999.29 61669.03 42306.02 29415.42 34979.46 31395.12 31369.03 27680.12 25902 29108.72 32085.23 21361.55 60644.89 42148.88 70452.95 Acetoacetate 3908.11 7455.8 9128.84 3862.59 5712.08 1615662 1348549.5 1963866.38 1571996 1959971.12 1897742.88 2589767.25 1930904.62 3137717.75 3211359.25 1639112.5 1783902.38 1759722.12 764795.56 1007625.69 1149230 1660988 1512716 2075122.88 1671743.88 2218103.25 1839119.38 2642084 2324332.25 2498177.25 2327350.25 2935162.75 3037026 3014187 2088448 1949001 2153431.75 L-Serine - - - - - 289708.41 275413.69 329299.5 290979.53 360013.34 369005.59 500931.41 450067.09 628127.81 545649.75 389498.38 377351.25 360384.5 256388.12 221676.25 298540.16 281464.78 295415.91 380613.75 336548.16 366503.5 342688.88 476457.03 544730.38 585021.19 492475.38 488789.16 546507.19 434227.38 329315 331335.31 380855.91 MALEAMATE - - - 1200.14 - - - - - - - - 3900.12 6842.18 - 8989.46 - 5165.68 21590.35 39417.12 25662.87 3057.55 4617.41 - 1850.17 - - - - 4687.91 - 46883.76 65169.69 63863.64 52914.14 57036.11 56540.7 L-PROLINE 1760.52 2414.14 2111.47 1633.67 1957.94 444008.62 373576.88 363436.16 250778.61 296779.38 348126.12 279710.59 396049.97 373744.78 322141.34 413968.53 443536.16 463444.84 479165.66 524793.94 534569.38 287798.62 239950.81 338303.09 301440.84 295025 253013.38 337405.47 360030.91 304356.84 260651.23 275052.53 318393.16 263837.53 323910.28 314441.12 406261.34 3-Methyl-2-oxobutanoic acid 130635.37 110114.27 121636.31 166067.42 129996.62 578685.12 515588.03 333186.72 285483.16 262138.62 234617.19 188793.19 165824.58 153209.52 160398.66 539743.88 516072.03 484413.16 665540.69 602439.5 627783.06 131475.08 120442.51 152793.52 141153.3 102738.41 125126.25 146808.92 116460.38 145305.27 176199.02 125508.5 117481.52 134379.48 133460.73 144632.08 134640.52 Fumarate 155231.58 178497.58 143351.28 148157.8 166806.48 45667.03 57368.36 41439.5 42905.88 47972.18 45563.57 43410.61 40748.93 38510.64 58504.75 48289.69 58613.14 60212.42 54436.55 73457.59 58768.08 52754.71 54373.72 46544.36 49256.23 59138.2 77863.44 30515.99 53788.67 63658.14 63359.45 48943.82 26202.96 51308.54 47956.86 83758.02 39114.39 L-Valine 4170.12 6956.04 6295.66 4456.77 7272.61 859716 1054967.88 952495.19 1060229.5 1310949 1627942.38 1742398 1678923.5 2317524.25 2192872 2033723.62 1811228.38 2086597.12 1010601.31 873803.81 1040039.19 879564.06 911877.81 1297077 1190414 1371562.12 1315609.12 1784044.38 1842970.5 1858422 1723391.62 1769700 1794101.62 1979473 1270628 1159016 1130607.62 Succinate 588461.25 554479.25 591843.81 634912.69 683580.31 228274.3 198275.83 152032.64 148488.92 157764.3 183955.8 229268.64 216194.62 345259.22 282181.16 741049.69 681969.06 659760.69 271586.94 223916.27 316427.5 136527.02 135451.33 153265.72 158450.75 157331.22 147371.31 117852.52 136256.09 128514.4 169901.27 146866.94 151103.58 118367.71 137249.03 149942.98 110164.21 L-Threonine - - - - - 642443.44 647389.31 794553.75 635429.25 957953.31 991489.94 1043902.44 1252785.38 1681741 1410001.38 1219223.62 1339526.75 1230239 585445.94 541132.56 718865.44 575528.19 525166.62 875582.69 720344.94 926060.81 720643.94 1255015.38 1328702.75 1443650.12 1138064.12 1178013.5 1354626.12 1280372 770240.31 713497.69 703267.81 4-HYDROXYBENZALDEHYDE 12120341 12338707 12830395 13172663 14162775 13499464 13108793 14241696 14286904 13914341 13257128 13689539 13524573 14883825 13390832 12405696 12139328 11430955 11671561 11922563 13658455 12699344 12555863 14043607 13622575 13989115 13894960 13784745 14522739 13845429 13534291 11942657 11649272 12488387 12788421 13641755 14212283 Thymine 3369 - - 1791.03 1788.13 583644.75 607260.38 69761.93 429186.38 289642.84 283436.88 119304.37 133684.22 11577.96 6122.12 4219.23 11043.99 12551.91 530139 508099.25 724422.06 - 506250.25 131209.7 509322.09 297493.34 292462.88 173935.69 138715.23 2302.04 4948.16 - - 1105.43 590889.19 589425.69 611071.81 Pyroglutamic acid 2721.91 1600.42 4558.16 2062.91 4857.51 8991.94 16827.89 11279.57 14374.27 9955.89 11476.03 12263.85 7064.14 11516.16 12355.67 21387.01 25073.22 17206.56 12488.62 23841.8 20555.47 15572.47 16403.72 10329.21 10238.67 8005.33 10988.57 12539.84 4665.63 8170.96 8946.9 2342.03 5324.6 2555.92 16662.88 18981.89 14629.24 5-Oxoproline 2279.23 2697.55 4935.87 2300.71 5141.81 165360.61 164433.08 95637.29 97324.23 82619.04 90614.6 85132.52 81205.66 90781.37 84082.52 361736.25 330745.47 302744.59 215545.44 243734.56 238194.92 84133.88 77977.8 65388.78 64031.54 61305.64 56948.7 75506.84 50612.06 60988.22 45390.56 61950.74 74593.43 74404.28 95878.31 82479.35 92377.37 Citraconic acid 126157.5 125327.9 143049.16 135090.06 135094.45 109904.97 160726.75 153945.23 137582.16 163494.67 176058.62 216717.67 194295.39 315624.06 316115.12 263399.66 281743.59 284503.41 128148.22 194243.27 137253.55 189206.89 137432.58 134819.86 166869.12 206342.06 196688.56 226752.73 228735.14 301750.22 315966.72 333727.38 307520.75 300410.53 120409.9 237570.33 137085.59 L-Leucine 22788.87 27410.22 28110.35 22137.62 20730 3907600.25 3292977.25 4464197.5 4419452 5690724.5 5933530.5 7136097.5 7047806.5 9739145 9656058 8958039 8771198 7914408.5 3648967.75 4182994.75 3863053.25 4464524.5 4364420.5 5238214.5 5566841.5 6226406.5 6175772 8330020 7125594.5 8103873.5 7754442.5 8154158.5 8137057.5 8086156.5 5236612.5 4714482 4741368.5 L-Asparagine 2328.29 2012.68 - 2294.61 2002.48 284950.72 251937.2 270066.66 210042.39 228484.42 247931.05 217860.02 253162.33 293034.19 282689.5 338935.75 371240.22 304394.97 286679.34 249174.23 332112.59 203890.27 202035.31 239558.88 192488.3 241143.52 173546.06 262811.28 257716.81 240858.31 214019.62 213889.5 218511.8 216647.98 274230.22 221479.2 230654.88 L-ORNITHINE - 1300.18 2135.8 - - 81089.15 86798.3 54944.57 72116.3 73741.69 55272.69 70292.91 70789.48 84420.59 68059.34 68226.81 - 52379.98 88106.09 84652.22 95739.75 54419.34 55020.22 54562.27 60818.09 62439.77 57651.97 73298.24 57561.68 57592.88 62243.34 53204.34 55672.58 49972.29 52644.57 49100.59 59674.06 Aspartate - 2016.62 2025.64 - - 350842.16 348376.66 267880.09 237080.38 268423.09 254729.48 242683 212994.77 280348.47 225220.08 6352.02 5248.07 5692.02 400749.78 424217.25 443383.09 343320.38 329101.09 268446.16 288847.75 295190.59 297889.5 349199.78 227065.27 276014.25 272578.56 282622.5 292497.28 335735.31 466655.38 354328.41 412604.78 malate 73831.29 54473.78 75204.91 76853.24 60526.93 279256.94 269933.5 159854.88 150569.17 139375.92 99772.63 115792.05 111099.78 73135.44 104770.29 463906.78 408498.75 351272.84 311322.84 305654.09 329612.16 82779.98 63225.16 112557.54 74500.06 95258.72 85151.05 70157.07 72001.55 86618.6 78552.92 85147.57 71979.91 83586.94 86045.06 73687.32 89975.37 Hypoxanthine - - - - - 49933.64 66239.38 55692.74 56529.19 50051.97 49480.44 52261.52 50534.45 69465.09 67296.71 2578.69 2989.32 - 13659.71 16747.14 19357.93 79111.69 95946.6 63244.7 80820.12 75321.59 82894.98 90466.6 69434.56 62624.11 59856.84 54618.19 54776.25 49279.8 121752.84 110946.5 112827.06 a-ketoglutarate 66472.27 83542.57 70899.87 76586.8 77362.57 304476.31 95719.4 419065.12 385510.41 744191 626414.31 1283960 1325876.38 2108537.25 1902268.88 4370222 4358241.5 4169670.75 92627.69 110402.71 118901.12 75435.04 70442.02 148723.94 148668.34 219014.06 228684.88 416974.84 380866.84 417328.09 441776.16 602261.19 601808.94 558794.69 85523.28 66322.54 71416.73 L-Glutamine - - - - - 4323567.5 4469475.5 5799356 5658594 6525652 6094453.5 7753528 7543737.5 8160076.5 7303309.5 5385495.5 5082175.5 5155346.5 3564248.25 3643408.75 4003424 5981808.5 5963541.5 4970694 4557390.5 4284458.5 3693598.75 3762125.75 3693262.75 2618275.25 2132839.75 1948623.38 2118025 1973651.12 6150644 5996224 5968493.5 L-LYSINE - - - - - 158099.89 138373.73 175342.08 185701.61 200981.45 237968.25 271787.53 289251.12 408667 393733.38 287043.16 261046.8 280536.59 98017.68 126136.41 135033.55 140740.17 115632.85 197548.2 220369.25 228851.08 228215.42 314148.78 285481.03 427815.5 300079.41 311433.19 241840.92 230745.83 135845.3 153579.16 145787.05 L-Glutamate - - - - - 1281139.88 1296751.62 738412.5 772735.94 649432.38 633733.75 666581.12 661634.19 840398.31 705659.5 2324368 2211544.75 1957706.62 1365826.25 1443171.5 1413685.62 507063.25 512407.62 499872.25 471684.16 561597 417668.25 565885.69 423865.84 425985.5 421246.12 356678.09 429489.75 440719.03 638680.88 553971.06 625487.44 CITRAMALATE 45603.74 47739.92 55443.51 43812.34 40555.04 71316.07 54732.2 173086.38 155317.27 418849.75 353425.66 611960.25 502383.16 897243.81 914823.81 752391.75 868724.19 693905.88 67507.51 58699.31 84642.1 57547.12 41442.65 213646.61 193688.27 417729.34 458092.97 795963 603164.31 837821.19 780904.56 851473.94 917998.19 1007777.81 69444.34 55919.21 57560.39 L-METHIONINE - - - - - 286431.78 275194.97 335814.28 292412.72 384550.38 348618.91 476080.5 446950.12 689392.81 515463.91 730902.31 685764.69 602135.5 250155.23 263911.34 264803.75 263541.53 257566.2 389739.97 297395.19 420764.66 375177.84 524215.03 482499.66 487789.91 441729.09 569597.06 582131.81 599371.81 421980.53 359714.59 329722.78 D-Ribose - - 2053.01 1993.34 - 315918.22 257606 295006.59 346761.19 301888.91 390638.09 361411.66 473296.59 496896.16 537915.5 367687.5 326818.16 348849.09 193645.67 213549.95 211118.06 269555.5 300980.84 349158.28 292936.97 333257.28 358308.03 516141.72 460834.84 537534.75 409659.25 508513.59 601256 481785.75 342813.41 347406.16 391417.91 L-HISTIDINE - - 1534.01 - - 149887.89 134753.44 166616.41 122165.65 178976.62 166934.58 187545.89 181554.98 248153.3 181314.45 295310.12 265208.03 236951.95 143156.45 194678 150681.39 153243.95 124527.94 157272.56 142177.22 174409.58 135323.7 196417.23 137475.81 197155.14 156308.81 231407.39 253607.73 235015.75 188961.8 171120.7 173221.95 3-HYDROXY-3-METHYLGLUTARATE 4078.8 6469.26 3983.17 7980.8 6746.25 2230748.75 1927511.62 2690037.75 2333885.25 2896827.25 2723695 3466655.25 3154147.25 4732692 4305195 2600344.25 2543730.25 2205262.75 1214470.5 1535843 1478572.5 2540090.25 2153908.25 2833253.75 2006453.38 2875444 2635042.5 3801537.25 3686770 3970222.75 3670132.75 4489255.5 4617478.5 5054112.5 2874982.25 2360998.75 3103778 L-Phenylalanine 1639.75 1883.46 1814.51 1814.96 - 396787.75 314586.5 385426.91 362564.34 501689.03 477918.34 577197.19 559066.44 867011.94 739810.19 842985.19 690500.75 739564.25 347526.72 429783 405396.5 320121.5 329886.66 419875.5 385798.88 427455 496825.47 632318.06 542157.31 611350.25 588478.25 612752.31 675043.31 740822.25 465877.75 435635.59 403625.16 arginine - 1668.73 - - - 253633 235707.92 316862.97 333160.56 326989.34 347919.5 339956.47 325098.16 469464.12 447457.75 351328.03 365049.91 301246.84 190545.11 208534.3 206611.95 325605.44 323139.28 359118.97 374372.66 396915.34 267576.84 384776.12 359057.38 432589.53 342248.91 419019.47 410833.47 367840.22 402630.09 367351.16 319790.97 N-ACETYL-L-ASPARTIC ACID 5110.1 4589.26 3517.8 - 3764.54 46495.58 16362.37 15478.82 24259.91 - 6558.8 10655.89 7526.47 5605.69 - 85398.35 97948.73 98853.51 174206.17 159901.56 197749.7 - - - - - 10819.21 - - - 3469.08 - - - 5273.05 - 5749.66 D-Glucono-1-5-lactone - - - - - 20648.9 22559.76 18096.56 23677.26 22488.88 25364.82 31531.74 21414.21 30428.28 29071.79 17490.29 15615.14 19837.64 15548.11 20724.13 11070.87 17163.64 19440.32 21695.1 17551.29 8451.03 24927.88 28912.7 31313.24 24769.1 34573.23 19130.63 36592.55 39743.73 25934.31 35077.39 22569.24 ALPHA-D-GLUCOSE - 1933.92 - - 1735.56 10349601 13612131 12783976 15188419 13236288 16036875 18604634 19028898 21679874 20869592 16209597 15258132 15159179 9211338 10893488 10239907 12456599 11192485 15794752 13965488 15497208 16218352 17058792 19182670 20568738 17738600 20077534 22175502 19670502 15280016 13944167 14190363 L-Tyrosine - - 3665.55 - - 695551.25 595423.44 694248.5 714122.81 845073.19 825113.75 975179.06 1029464 1390664 1368573.38 1303688.25 1201992.12 1030590.69 637179.06 706227.19 682411.69 611622.44 568244.88 633757.19 732353.5 855718.44 869864.25 1231342.88 1024707.19 1003987.69 1066765.88 1044744.31 974649.19 1013821.69 773290.31 703764.31 726129.75 O-Phospho-L-serine - - - - - 27821.19 35889.78 20870.69 15698.53 12404.66 17958.59 19522.15 18376.12 27605.63 19563.23 50901.29 48735.73 45859.63 33260.41 40221.35 40355.99 16871.01 13394.25 9838.24 16616.81 20643.8 11625.25 17630.64 11612.83 13095.15 11974.62 6347.02 5463.72 14578.23 17712.24 23395.95 15202.89 citrate 49358.65 45673.14 80350.16 55952.56 47513.83 56145.2 45575.93 67880.01 39623.57 70259.88 53802.95 75142.93 54032.04 48181.32 54844.17 61397.78 69019.29 66703.8 59134.64 79445 92671.48 70997.75 44674.29 72992.62 50037.54 72461.71 57079.08 63652.67 66846.04 64910.65 51807.25 63864.44 66192.84 77720.04 55658.97 90843.2 78696.92 DEOXYCYTIDINE - - - - 3257.36 11410.38 10074.96 15884.27 11169.97 25564.61 16558.79 19719.1 27202.61 27278.06 26374.87 41340.43 21263.19 - - - - 12966.23 13875.99 12214.86 16783.04 15434.94 16871.85 30493.58 17204.36 22202.93 23210.86 - - 3788.9 1787.77 - - deoxyuridine 1480.29 - - - - 1884190.62 1810675.88 2141823.75 2040774.38 2286515.75 2160404.25 2272751.75 2193513 2818057 2631911 1668453 1420365 1594501.88 1673291.88 1533058.5 1926762.62 2301301.75 2270936.75 2061378 1726835.62 1526904.88 1416457.88 1292642.25 1125106.38 808345.69 736126.69 648429.94 753916.31 596630.12 2792568 2668845.75 2781867 Cystine - - - - - 87606.66 87359.57 96976.23 96630.65 113112.72 124580.32 162435.11 116875.21 140273.98 191362.83 52296.25 34932.07 47853.09 98041.8 86392.07 109891.41 134472.48 103330.98 144953.78 115764.41 112191.56 144840.77 142842.77 163883.94 150971.19 134175.2 155008.77 136900.28 164882.42 150323.02 144961.61 120719.3 thymidine 2099.23 1402.95 - - - 17692.1 31555.21 27591.18 25143.54 35464.19 34737.07 49843.46 42311.27 36777.55 42841.08 35096.76 35842.25 28790.62 27798.8 39519.33 31028.43 22799.96 27294.02 27119.82 14644.48 33440.7 41491.48 41356.04 47035.8 39929.65 53738.59 45567.09 69687.25 52523.11 20620.73 39523.79 42954.32 aminoimidazole carboxamide ribonucleotide - 1281.62 - - - 150325.12 175442.17 197047.81 202017.17 209112.25 206660.45 213083.52 267491.09 299594.88 314756.5 192979.69 186068.31 214110.05 212983.67 177280.17 185291.69 172661.3 172911.83 182497.86 206883.45 196894.2 226672 289777.84 280078.62 323609.22 243526.12 260285 356325.75 306157.34 218484 194619.44 180596.19 Sedoheptulose bisphosphate - 1618.87 - - 1628.13 204503.38 181436.52 179948.23 166163.23 149707.27 191334.05 160387.28 172255.55 141239.53 174896.14 142470.7 99946.9 133334.92 - - - 166259.33 150327.38 168523.61 177953.14 138601 155166.33 139415.02 135615.92 152619.38 147690.27 - - - - - - folate - - - - - 49305.08 22741.35 20851.16 35534.73 56980.86 36711.23 54818.01 40864.21 58472.7 69159.59 47748.48 50329.42 45928.58 37361.75 34370.07 44450.89 40099.86 36853.76 51748 46575.79 37480.98 51061.41 46740.22 58256.88 57959.86 43316.42 42572.25 27801.05 47728.3 33395.26 35552.9 24466.04 metabolite_name Pyruvate L-Alanine lactate Acetoacetate L-Serine MALEAMATE L-PROLINE 3-Methyl-2-oxobutanoic acid Fumarate L-Valine Succinate L-Threonine 4-HYDROXYBENZALDEHYDE Thymine Pyroglutamic acid 5-Oxoproline Citraconic acid L-Leucine L-Asparagine L-ORNITHINE Aspartate malate Hypoxanthine a-ketoglutarate L-Glutamine L-LYSINE L-Glutamate CITRAMALATE L-METHIONINE D-Ribose L-HISTIDINE 3-HYDROXY-3-METHYLGLUTARATE L-Phenylalanine arginine N-ACETYL-L-ASPARTIC ACID D-Glucono-1-5-lactone ALPHA-D-GLUCOSE L-Tyrosine O-Phospho-L-serine citrate DEOXYCYTIDINE deoxyuridine Cystine thymidine aminoimidazole carboxamide ribonucleotide Sedoheptulose bisphosphate folate