Summary of project PR000197
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000197. The data can be accessed directly via it's Project DOI: 10.21228/M8XK51 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000197 |
| Project DOI: | doi: 10.21228/M8XK51 |
| Project Title: | Metabolomic Diagnostics in the Horse |
| Project Summary: | In this project we will investigate the feasibility of metabolomics and to characterize the diversity of metabotypes in the horse, towards discovery of markers and pathways associated with obesity and insulin resistance in the equine model. The collaborative team of researchers assembled for this work have identified horses severely affected with Equine Metabolic syndrome, often characterized by obesity and hyperinsulinemia. These animals are all from the Arabian breed, to control for some genetic background. Horses are age, sex and farm of residence matched with a control animal whenever possible. Carefully controlled collection protocols were utilized to ensure minimal variability in sample age and quality. Blood plasma is submitted for both global LC-MS analysis through the SECIM core facilities. This discovery-based approach will begin to generate new targets for the development of novel therapeutic interventions for the treatment and prevention of obesity, type-2 diabetes as well as related secondary conditions in both humans and horses. Finally, as the first dataset of its kind in the horse, we may also be able to highlight promising new biomarkers for veterinary diagnostic use. |
| Institute: | University of Florida |
| Laboratory: | Brooks Lab |
| Last Name: | Brooks |
| First Name: | Samantha |
| Email: | samantha.brooks@ufl.edu |
| Phone: | 352-273-8080 |
| Funding Source: | Southeastern Center for Integrated Metabolomics (SECIM) pilot and feasibility funding, NIH U24 DK097209 |
Summary of all studies in project PR000197
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000244 | Metabolomic Diagnosis in Horse | Equus caballus | University of Florida | MS* | 2016-09-23 | 1 | 51 | Uploaded data (21.5G)* |
