Summary of project PR002225

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002225. The data can be accessed directly via it's Project DOI: 10.21228/M81833 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002225
Project DOI:doi: 10.21228/M81833
Project Title:Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3
Project Summary:The interplay of RNA modifications – deposited by “writers”, removed by “erasers” and identified by RNA binding proteins known as “readers” – forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a “reader” of the N6-methyladenosine (m6A) modification and crucial for regulating gene expression. Here, we report the novel finding that the “reader” IGF2BP3 changes cellular metabolism, resulting in an altered ability of the “writers” to modify the epitranscriptome. Specifically, loss of IGF2BP3 caused a reduction in glycolytic flux and one-carbon metabolism, leading to decreased production of S-adenosyl methionine, a key substrate for methylation reactions within the cell.
Institute:University of California, Los Angeles
Last Name:Rao
First Name:Dinesh S
Address:12-272, Factor Building, 650 Charles E Young Drive, UCLA, USA 90095
Email:gunjansharma@mednet.ucla.edu
Phone:3108252548

Summary of all studies in project PR002225

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST003597 Metabolic regulation of RNA methylation by the m6A-reader IGF2BP3 Homo sapiens University of California, Los Angeles MS 2025-09-28 1 12 Uploaded data (3G)*
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