Summary of project PR002340
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002340. The data can be accessed directly via it's Project DOI: 10.21228/M85C1M This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002340 |
| Project DOI: | doi: 10.21228/M85C1M |
| Project Title: | Ultrahigh-performance liquid chromatography–high-resolution mass spectrometry-based tissue lipidomics study of thymoma and thymic hyperplasia |
| Project Type: | non-targeted lipidomics analysis |
| Project Summary: | Thymoma is a rare malignant thymic epithelial tumor (TET) with an incidence of about 2 to 4 per million. In this study, we performed nontargeted lipidomic profiling study of tissue samples from 39 patients with thymoma and thymic hyperplasia using UPLC-HRMS. OPLS-DA classification models enabled discrimination of tumor from adjacent noncancerous tissue (ANT) and distant noncancerous tissue (DNT) samples in thymoma with good accuracy, sensitivity, and specificity using 5 discriminant compounds. The discriminant feature panels were verified by external validation sets, revealing characteristic lipid signatures associated with thymoma and showing prospects for entering the next evaluation stage of biomarker discovery for thymoma detection, giving hints to potential treatment targets for the disease. |
| Institute: | Ocean University of China |
| Department: | Department of Medicine and Pharmacy |
| Laboratory: | Analytical chemistry |
| Last Name: | Zhang |
| First Name: | Jie |
| Address: | No. 5 Yushan Road, Qingdao, Shandong, China |
| Email: | zhangjieqau@163.com |
| Phone: | 17806277823 |
| Funding Source: | ocean university of China |
Summary of all studies in project PR002340
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003756 | Ultrahigh-performance liquid chromatography–high-resolution mass spectrometry-based tissue lipidomics study of thymoma and thymic hyperplasia | Homo sapiens | Ocean University of China | MS* | 2025-08-15 | 1 | 89 | Uploaded data (4.1G)* |
