Summary of project PR002379
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002379. The data can be accessed directly via it's Project DOI: 10.21228/M84831 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002379 |
| Project DOI: | doi: 10.21228/M84831 |
| Project Title: | Epigenetic changes, neuronal dysregulation and behavioral abnormalities in Zmym2+/- mutant mice, a genetic animal model of schizophrenia and neurodevelopmental disorders |
| Project Summary: | Loss-of-function mutations in ZMYM2 are associated with an increased risk for schizophrenia (SCZ) and neurodevelopmental disorders (NDD). ZMYM2 interacts with proteins that regulate histone modifications and gene expression, but its functions in the brain are unclear. In this multi-omics study, we found that Zmym2 heterozygous knockout in mice leads to widespread disturbance of gene expression and alterations in diverse molecular pathways, including those related to histone modifications and neuronal activity, particularly in neurons. Proteomic analysis of synapses uncovered dysregulation in lipid metabolism and neurofilament pathways. In neurophysiologic and behavioral tests, Zmym2+/- mutant mice exhibit abnormal EEG patterns and locomotor activity. Our findings underscore the critical role of ZMYM2 in brain development and function and establish Zmym2 mutant mice as a useful genetically valid animal model for SCZ and NDD. |
| Institute: | Broad Institute |
| Last Name: | Mashin |
| First Name: | Eivgeni |
| Address: | 300 Binney St., Cambridge, Massachusetts, 02142, USA |
| Email: | emashin@broadinstitute.org |
| Phone: | 6177147061 |
| Contributors: | Wei-Chao Huang, Kira A. Perzel Mandell, Sameer Aryal, Bryan J. Song, Antia Valle-Tojeiro, Nathaniel Goble, Chuhan Geng, Ahmet S. Asan, Xiao-Man Liu, Courtney Dennis, Lucas Dailey, Amy Deik, Lucia Inunciaga, Eivgeni Mashin, Zohreh Farsi, Yining Wang, Jen Q. Pan, Clary B. Clish, Hasmik Keshishian, Steven A. Carr, Morgan Sheng |
Summary of all studies in project PR002379
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003805 | Epigenetic changes, neuronal dysregulation and behavioral abnormalities in Zmym2+/- mutant mice, a genetic animal model of schizophrenia and neurodevelopmental disorders | Mus musculus | Broad Institute of MIT and Harvard | MS* | 2025-09-15 | 1 | 10 | Uploaded data (6.5G)* |
