Summary of study ST000706

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000503. The data can be accessed directly via it's Project DOI: 10.21228/M8ND66 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000706
Study TitleEffect of DASH Diet on Gut Microbiome (SCFA from stool)
Study TypeMS analysis
Study SummaryThis research will examine the effect of the currently recommended DASH diet versus a Vegetarian DASH diet on the gut microbiome and risk for cardiovascular disease in pre-hypertensive obese African American women. We will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups5
Total Subjects13
Study CommentsWe will define the gut microbiota profile, short chain fatty acid production, breath hydrogen/methane response, plasma lipopolysaccharide production and other biomarkers of inflammation in response to diet type in obese African American pre-hypertensive females at baseline and following placement on the traditional DASH plan or DASH Vegetarian diet. We will also define these parameters in African American women adhering to a Vegetarian or Vegan Diet. Our goal is to determine how the gut microbiome modulates host physiology and immune function in response to diet type. By evaluating the effect of a recommended DASH dietary pattern versus a Vegetarian DASH plan on the gut microbiome and its fermentation products, we aim to identify novel information about how these diet types strategically reduce cardiovascular disease risk through gut:microbiota:host interaction.
Raw Data AvailableYes
Raw Data File Type(s).D
Analysis Type DetailGC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8ND66
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR000503
Project DOI:doi: 10.21228/M8ND66
Project Title:Effect of DASH Diet on Gut Microbiome
Project Type:MS analysis
Project Summary:Effect of DASH Diet on Gut Microbiome
Institute:Morehouse School of Medicine
Department:Clinical Research Center
Laboratory:Umeakunne Lab
Last Name:Umeakunne
First Name:Kayellen
Address:Atlanta, GA
Email:kumeakunne@msm.edu
Phone:404-752-1010

Subject:

Subject ID:SU000729
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Human

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id GROUP Timepoint
SA039893S00019911pre-hypertensive Baseline
SA039894S00019913pre-hypertensive Baseline
SA039895S00019912pre-hypertensive Final
SA039896S00019914pre-hypertensive Final
SA039892S00020331- -
SA039897S00019922vegetarian NA
SA039898S00019923vegetarian NA
SA039899S00019921vegetarian NA
SA039900S00019924vegetarian NA
SA039901S00019918vegetarian NA
SA039902S00019915vegetarian NA
SA039903S00019916vegetarian NA
SA039904S00019917vegetarian NA
SA039905S00019919vegetarian NA
SA039906S00019920vegetarian NA
Showing results 1 to 15 of 15

Collection:

Collection ID:CO000723
Collection Summary:-
Sample Type:Feces

Treatment:

Treatment ID:TR000743
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000736
Sampleprep Summary:-
Sampleprep Protocol Filename:A007_-_Short_Chain_Fatty_Acids.pdf

Combined analysis:

Analysis ID AN001097
Analysis type MS
Chromatography type GC
Chromatography system Agilent 7890N
Column Phenomenex Zebron ZB-WAXplus (30m x 0.25mm, 0.25um)
MS Type EI
MS instrument type Single quadrupole
MS instrument name Agilent 5975
Ion Mode POSITIVE
Units nmol/mg

Chromatography:

Chromatography ID:CH000771
Instrument Name:Agilent 7890N
Column Name:Phenomenex Zebron ZB-WAXplus (30m x 0.25mm, 0.25um)
Chromatography Type:GC

MS:

MS ID:MS000992
Analysis ID:AN001097
Instrument Name:Agilent 5975
Instrument Type:Single quadrupole
MS Type:EI
Ion Mode:POSITIVE
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