Summary of Study ST001313

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000890. The data can be accessed directly via it's Project DOI: 10.21228/M8ND7K This work is supported by NIH grant, U2C- DK119886.

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Study IDST001313
Study TitleLipid expression in serum after early life exposure to an endocrine disruptor and a Western Diet at 240 days postnatal (part-IV)
Study TypeLipid expression after chemical exposure versus control
Study SummaryOur early-life environment has a profound influence on developing organs that impact metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life exposure causes metabolic dysfunction in adulthood and reprograms histone marks in the developing liver to accelerate acquisition of an adult epigenomic signature. This epigenomic reprogramming persists long after the initial exposure, but many reprogrammed genes remain transcriptionally silent with their impact on metabolism not revealed until a later life exposure to a Western-style diet. Diet-dependent metabolic disruption was largely driven by reprogramming of the Early Growth Response 1 (EGR1) transcriptome and production of metabolites in pathways linked to cholesterol, lipid and one-carbon metabolism. These findings demonstrate the importance of epigenome:environment interactions, which early in life accelerate epigenomic aging, and later in adulthood unlock metabolically restricted epigenetic reprogramming to drive metabolic dysfunction.
Institute
Baylor College of Medicine
Last NameWalker
First NameCheryl
Address1 Baylor Plaza, Houston, TX, 77030, USA
EmailCheryl.walker@bcm.edu
Phone713-798-8219
Submit Date2020-01-24
Num Groups2
Total Subjects10
Num Males10
Analysis Type DetailLC-MS
Release Date2020-03-11
Release Version1
Cheryl Walker Cheryl Walker
https://dx.doi.org/10.21228/M8ND7K
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN002186 AN002187
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Shimadzu Nexera-x2 Shimadzu Nexera-x2
Column Acquity HSS UPLC T3 column (1.8 μm particle 50 × 2.1 mm) Acquity HSS UPLC T3 column (1.8 μm particle 50 × 2.1 mm)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name ABI Sciex 5600 TripleTOF ABI Sciex 5600 TripleTOF
Ion Mode POSITIVE NEGATIVE
Units peak intensity peak intensity

Chromatography:

Chromatography ID:CH001601
Instrument Name:Shimadzu Nexera-x2
Column Name:Acquity HSS UPLC T3 column (1.8 μm particle 50 × 2.1 mm)
Chromatography Type:Reversed phase
  
Chromatography ID:CH001602
Instrument Name:Shimadzu Nexera-x2
Column Name:Acquity HSS UPLC T3 column (1.8 μm particle 50 × 2.1 mm)
Chromatography Type:Reversed phase
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