Summary of Study ST000054

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000051. The data can be accessed directly via it's Project DOI: 10.21228/M8MS3J This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000054
Study TitleMetabolic Microenvironments in Normal Breast and Breast Cancer (MS analysis)
Study TypeMetabolomic analysis of normal breast tissue
Study SummaryThe purpose of this study was to understand the metabolomic changes in a breast tissue microenvironment at various stages of cancer development and progression (i.e. normal breast, DCIS, and invasive cancer). The goal of this metabolomics pilot and feasibility study was to apply a broad spectrum GC-MS metabolomics method to determine whether changes in normal tissue of women with cancer correlate with progression and or the subtype of the disease.
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Submit Date2014-04-30
Num Groups8
Total Subjects192
Study Commentssample preparation and analysis randomized with data collection over multiple days
Publications1. Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Roman-Perez E, D’Arcy M, Freemerman AJ, Perou CM, Troester MA: Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res 2012;19:571-585. 2. J Budczies, C Denkert, B Muller, S Brockmoller, F Klauschen, B Gyorffy, M Dietel, C Richter-Ehrenstein, U Marten, R Salek, J Griffin, M Hilvo, M Oresic, G Wohlgemuth, O Fiehn: Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue – a GC-TOFMS based metabolomics study. BMC Genomics 2012; 13:334.
Raw Data AvailableYes
Raw Data File Type(s)cdf
Uploaded File Size8.4 G
Analysis Type DetailGC-MS
Release Date2018-08-27
Release Version1
Susan Sumner Susan Sumner application/zip

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Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id treatment pool aliquot
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SA002630140217ajcsa17_1Basal no
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SA002632140217ajcsa46_1Basal no
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SA002639140214ajcsa44_1Basal no
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SA0026421402110jcsa19_1Basal no
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SA002644140219ajcsa19_1Basal no
SA002645140219ajcsa24_1Basal no
SA0026461402110jcsa12_1Basal no
SA002647140219ajcsa22_1Basal no
SA002648140219ajcsa28_1Basal no
SA002649140219ajcsa36_1Basal no
SA002650140217ajcsa36_1Basal yes
SA0026511402110jcsa44_1Basal yes
SA002652140214ajcsa35_1Basal yes
SA002653140219ajcsa26_1Basal yes
SA002654140219ajcsa45_1DCIS no
SA002655140214ajcsa45_1DCIS no
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SA002677140219ajcsa29_1DCIS no
SA002678140219ajcsa40_1DCIS no
SA002679140214ajcsa36_1DCIS yes
SA002680140217ajcsa19_1DCIS yes
SA0026811402110jcsa23_1DCIS yes
SA002682140219ajcsa10_1DCIS yes
SA002683140214ajcsa23_1HER2 no
SA002684140217ajcsa21_1HER2 no
SA002685140219ajcsa21_1HER2 no
SA002686140219ajcsa31_1HER2 no
SA002687140219ajcsa18_1HER2 no
SA002688140217ajcsa33_1HER2 no
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SA002690140217ajcsa28_1HER2 no
SA002691140217ajcsa14_1HER2 no
SA002692140214ajcsa42_1HER2 no
SA002693140214ajcsa12_1HER2 no
SA0026941402110jcsa36_1HER2 no
SA0026951402110jcsa45_1HER2 no
SA0026961402110jcsa46_1HER2 no
SA0026971402110jcsa43_1HER2 no
SA0026981402110jcsa28_1HER2 no
SA002699140214ajcsa21_1HER2 yes
SA002700140219ajcsa16_1HER2 yes
SA0027011402110jcsa47_1HER2 yes
SA002702140217ajcsa30_1HER2 yes
SA002703140217ajcsa37_1LumA no
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SA0027051402110jcsa10_1LumA no
SA002706140219ajcsa42_1LumA no
SA0027071402110jcsa26_1LumA no
SA002708140217ajcsa07_1LumA no
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SA0027121402110jcsa29_1LumA no
SA002713140217ajcsa24_1LumA no
SA0027141402110jcsa33_1LumA no
SA002715140214ajcsa47_1LumA no
SA002716140217ajcsa43_1LumA no
SA002717140219ajcsa23_1LumA no
SA0027181402110jcsa39_1LumA no
SA002719140219ajcsa43_1LumA no
SA002720140214ajcsa11_1LumA no
SA0027211402110jcsa25_1LumA no
SA0027221402110jcsa21_1LumA no
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SA0027241402110jcsa18_1LumA no
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SA002726140217ajcsa42_1LumA yes
SA002727140214ajcsa15_1LumA yes
SA002728140219ajcsa30_1LumA yes
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