Summary of Study ST000655

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000461. The data can be accessed directly via it's Project DOI: 10.21228/M8G609 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000655
Study TitleOmega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part II)
Study SummaryIn this study we have compared the metabolic effects of conventional soybean oil to those of genetically modified Plenish soybean oil, that is low in linoleic acid and high in oleic acid. This work builds on our previous study showing that soybean oil, rich in polyunsaturated fats, is more obesogenic and diabetogenic than coconut oil, rich in saturated fats (PMID: 26200659). Here, in order to elucidate the mechanisms responsible for soybean oil induced obesity, we have performed the first ever metabolomics (in plasma and liver) and proteomics on the livers of mice fed the two soybean oil diets (plus those fed a high coconut oil and Viv chow diet). Our results show that the new high oleic soybean oil induces less obesity and adiposity than conventional soybean oil, but can cause hepatomegaly and liver dysfunction. Metabolomic analysis reveals that the hepatic and plasma metabolic profiles differ considerably between the two soybean oils. Hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway were found to correlate positively with obesity.
Institute
University of California, Davis
DepartmentGenome and Biomedical Sciences Facility
LaboratoryWCMC Metabolomics Core
Last NameFiehn
First NameOliver
Address1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616
Emailofiehn@ucdavis.edu
Phone(530) 754-8258
Submit Date2017-06-22
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2017-07-01
Release Version1
Oliver Fiehn Oliver Fiehn
https://dx.doi.org/10.21228/M8G609
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id GROUP_DESCRIPTION TIME_POINT Genotype
SA037565CSH_PM D4-16 e3_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037566CSH_PM D4-18 e4_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037567CSH_PM D4-16 e1_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037568CSH_PM D4-16 e4_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037569CSH_PM D4-18 e2_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037570CSH_PM D4-18 e3_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037571CSH_PM D4-18 e1_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037572CSH_PM D4-16 e2_pos_MS_1032014.dHFD 24 weeks WT C57-Bl6
SA037573CSH_PM a7 D4-4 e4_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037574CSH_PM a7 D4-4 e2_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037575CSH_PM a7 D4-2 e2_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037576CSH_PM a7 D4-2 e1_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037577CSH_PM a7 D4-2 e3_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037578CSH_PM a7 D4-2 e4_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037579CSH_PM a7 D4-4 e1_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037580CSH_PM a7 D4-4 e3_pos_MS_1032014.dHFD 35 weeks HMZ a7
SA037581CSH_PM D4-9 e1_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037582CSH_PM D4-11 e3_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037583CSH_PM D4-9 e3_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037584CSH_PM D4-11 e1_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037585CSH_PM D4-10 e3_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037586CSH_PM D4-10 e2_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037587CSH_PM D4-10 e1_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037588CSH_PM D4-9 e2_pos_MS_1032014.dHFD 35 weeks WT C57-Bl6
SA037589CSH_PM D3-18 e3_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037590CSH_PM D3-18 e4_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037591CSH_PM D3-18 e2_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037592CSH_PM D3-17 e2_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037593CSH_PM D3-17 e1_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037594CSH_PM D3-18 e1_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037595CSH_PM D3-17 e4_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037596CSH_PM D3-17 e3_pos_MS_1032014.dLA-HFD 24 weeks WT C57-Bl6
SA037597CSH_PM a7 D3-4 e4_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037598CSH_PM a7 D3-1 e3_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037599CSH_PM a7 D3-5 e1_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037600CSH_PM a7 D3-4 e2_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037601CSH_PM a7 D3-5 e2_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037602CSH_PM a7 D3-5 e3_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037603CSH_PM a7 D3-5 e5_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037604CSH_PM a7 D3-5 e4_pos_MS_1032014.dLA-HFD 35 weeks HMZ a7
SA037605CSH_PM D3-12 e3_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037606CSH_PM D3-13 e3_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037607CSH_PM D3-12 e1_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037608CSH_PM D3-10 e4_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037609CSH_PM D3-10 e1_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037610CSH_PM D3-11 e2_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037611CSH_PM D3-11 e3_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037612CSH_PM D3-11 e1_pos_MS_1032014.dLA-HFD 35 weeks WT C57-Bl6
SA037613QC002N/A N/A N/A
SA037614QC003N/A N/A N/A
SA037615QC001N/A N/A N/A
SA037616CSH_PM PL-4 e3_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037617CSH_PM PL-4 e2_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037618CSH_PM PL-4 e4_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037619CSH_PM PL-5 e2_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037620CSH_PM PL-5 e4_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037621CSH_PM PL-4 e1_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037622CSH_PM PL-5 e1_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037623CSH_PM PL-5 e3_pos_MS_1032014.dPL-HFD 24 weeks WT C57-Bl6
SA037624CSH_PM 14 e3_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037625CSH_PM 14 e2_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037626CSH_PM 14 e4_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037627CSH_PM 16 e2_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037628CSH_PM 10 e1_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037629CSH_PM 16 e4_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037630CSH_PM 14 e1 _pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037631CSH_PM 16 e1_pos_MS_1032014.dViv chow 24 weeks WT C57-Bl6
SA037632CSH_PM a7 V-3 e1_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037633CSH_PM a7 V-1 e3_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037634CSH_PM a7 V-1 e2_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037635CSH_PM a7 V-2 e1_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037636CSH_PM a7 V-2 e2_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037637CSH_PM a7 V-3 e2_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037638CSH_PM a7 V-1 e4_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037639CSH_PM a7 V-3 e3_pos_MS_1032014.dViv chow 35 weeks HMZ a7
SA037640CSH_PM 9 e3_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037641CSH_PM 9 e4_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037642CSH_PM 9 e2_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037643CSH_PM 10 e2_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037644CSH_PM 10 e3_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037645CSH_PM 10 e4_pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
SA037646CSH_PM 9 e1 _pos_MS_1032014.dViv chow 35 weeks WT C57-Bl6
Showing results 1 to 82 of 82
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