Summary of Study ST000656

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000461. The data can be accessed directly via it's Project DOI: 10.21228/M8G609 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Show all samples  |  Perform analysis on untargeted data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files
Study IDST000656
Study TitleOmega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part III)
Study SummaryIn this study we have compared the metabolic effects of conventional soybean oil to those of genetically modified Plenish soybean oil, that is low in linoleic acid and high in oleic acid. This work builds on our previous study showing that soybean oil, rich in polyunsaturated fats, is more obesogenic and diabetogenic than coconut oil, rich in saturated fats (PMID: 26200659). Here, in order to elucidate the mechanisms responsible for soybean oil induced obesity, we have performed the first ever metabolomics (in plasma and liver) and proteomics on the livers of mice fed the two soybean oil diets (plus those fed a high coconut oil and Viv chow diet). Our results show that the new high oleic soybean oil induces less obesity and adiposity than conventional soybean oil, but can cause hepatomegaly and liver dysfunction. Metabolomic analysis reveals that the hepatic and plasma metabolic profiles differ considerably between the two soybean oils. Hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway were found to correlate positively with obesity.
Institute
University of California, Davis
DepartmentGenome and Biomedical Sciences Facility
LaboratoryWCMC Metabolomics Core
Last NameFiehn
First NameOliver
Address1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616
Emailofiehn@ucdavis.edu
Phone(530) 754-8258
Submit Date2017-06-23
Analysis Type DetailLC-MS
Release Date2017-07-01
Release Version1
Oliver Fiehn Oliver Fiehn
https://dx.doi.org/10.21228/M8G609
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id GROUP_DESCRIPTION TIME_POINT Genotype
SA037647CSH_PM D4-16 e3_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037648CSH_PM D4-16 e2_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037649CSH_PM D4-16 e4_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037650CSH_PM D4-17 e2_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037651CSH_PM D4-18 e4_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037652CSH_PM D4-16 e1_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037653CSH_PM D4-17 e1_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037654CSH_PM D4-18 e1_pos mode_MS_07212014.dHFD 24 weeks WT C57-Bl6
SA037655CSH_PM D3-17 e3reinject_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037656CSH_PM D3-17 e1_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037657CSH_PM D3-18 e3_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037658CSH_PM D3-17 e4_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037659CSH_PM D3-17 e2_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037660CSH_PM D3-18 e2reinject_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037661CSH_PM D3-18 e4_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037662CSH_PM D3-18 e1_pos mode_MS_07212014.dLA-HFD 24 weeks WT C57-Bl6
SA037663CSH_BioRec_02_pos mode_MS_07212014.dN/A N/A N/A
SA037664CSH_BioRec_03_pos mode_MS_07212014.dN/A N/A N/A
SA037665CSH_BioRec_01_pos mode_MS_07212014.dN/A N/A N/A
SA037666CSH_PM PL-5 e3_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037667CSH_PM PL-6 e4_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037668CSH_PM PL-6 e1_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037669CSH_PM PL-5 e1_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037670CSH_PM PL-5 e2_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037671CSH_PM PL-4 e3_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037672CSH_PM PL-4 e1_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037673CSH_PM PL-4 e4_pos mode_MS_07212014.dPL-HFD 24 weeks WT C57-Bl6
SA037674CSH_Viv-8_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037675CSH_Viv-9_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037676CSH_Viv-7_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037677CSH_Viv-4_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037678CSH_Viv-1_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037679CSH_Viv-2_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037680CSH_Viv-5_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
SA037681CSH_Viv-6_pos mode_MS_07212014.dViv chow 24 weeks WT C57-Bl6
Showing results 1 to 35 of 35
  logo