Summary of Study ST000670

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000473. The data can be accessed directly via it's Project DOI: 10.21228/M8X61Q This work is supported by NIH grant, U2C- DK119886.


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Study IDST000670
Study TitleExposure to high fat diets and bisphenol
Study TypeMS analysis
Study SummaryWild type (a/a) agouti mouse dams were randomized to one of three diets (control, mediterranean, western) two weeks prior to pairing with an agouti (Avy/a) sire. Diet exposure continued through pregnancy and lactation. All pups were weaned onto the control diet and then followed for metabolic phenotyping measures to 10 months of age. Comprehensive phenotyping (body composition, CLAMS, blood draw) was completed at 2, 4, and 8 months, with an OGTT at 8 months. Weekly weights were also recorded. The study examines whether prenatal dietary exposure to high fat diets (HFD) and bisphenol a (BPA, those groups will not be tested in this pilot) impacts metabolic programming in offspring as measured by hepatic steatosis, serum hormone levels, and epigenetic changes in hepatic lipid metabolism genes.
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Phone(734) 232-8175
Submit Date2017-06-05
Num Groups8
Total Subjects6
Study CommentsShotgun lipidomics will add insight into the potentially changing lipid composition of membranes in offspring following different prenatal diet exposures as a means of assessing risk of steatosis and metabolic changes.
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Diet Sex
SA038501S00019954Control + BPA Chow F
SA038502S00019958Control + BPA Chow F
SA038503S00019962Control + BPA Chow F
SA038504S00019952Control + BPA Chow F
SA038505S00019960Control + BPA Chow F
SA038506S00019956Control + BPA Chow F
SA038507S00019957Control + BPA Chow M
SA038508S00019955Control + BPA Chow M
SA038509S00019959Control + BPA Chow M
SA038510S00019953Control + BPA Chow M
SA038511S00019963Control + BPA Chow M
SA038512S00019961Control + BPA Chow M
SA038513S00019930Control Chow F
SA038514S00019932Control Chow F
SA038515S00019928Control Chow F
SA038516S00019927Control Chow M
SA038517S00019931Control Chow M
SA038518S00019929Control Chow M
SA038519S00019925Control Chow M
SA038520S00019926Control Chow M
SA038521S00019933Control Chow M
SA038522S00019968Mediterranean + BPA Chow F
SA038523S00019974Mediterranean + BPA Chow F
SA038524S00019972Mediterranean + BPA Chow F
SA038525S00019970Mediterranean + BPA Chow F
SA038526S00019966Mediterranean + BPA Chow F
SA038527S00019964Mediterranean + BPA Chow F
SA038528S00019969Mediterranean + BPA Chow M
SA038529S00019971Mediterranean + BPA Chow M
SA038530S00019973Mediterranean + BPA Chow M
SA038531S00019975Mediterranean + BPA Chow M
SA038532S00019965Mediterranean + BPA Chow M
SA038533S00019967Mediterranean + BPA Chow M
SA038534S00019941Mediterranean HFD Chow F
SA038535S00019937Mediterranean HFD Chow F
SA038536S00019939Mediterranean HFD Chow F
SA038537S00019936Mediterranean HFD Chow M
SA038538S00019938Mediterranean HFD Chow M
SA038539S00019942Mediterranean HFD Chow M
SA038540S00019940Mediterranean HFD Chow M
SA038541S00019934Mediterranean HFD Chow M
SA038542S00019935Mediterranean HFD Chow M
SA038543S00019986Western + BPA Chow F
SA038544S00019976Western + BPA Chow F
SA038545S00019978Western + BPA Chow F
SA038546S00019982Western + BPA Chow F
SA038547S00019980Western + BPA Chow F
SA038548S00019984Western + BPA Chow F
SA038549S00019985Western + BPA Chow M
SA038550S00019979Western + BPA Chow M
SA038551S00019977Western + BPA Chow M
SA038552S00019983Western + BPA Chow M
SA038553S00019987Western + BPA Chow M
SA038554S00019981Western + BPA Chow M
SA038555S00019950Western HFD Chow F
SA038556S00019948Western HFD Chow F
SA038557S00019946Western HFD Chow F
SA038558S00019945Western HFD Chow M
SA038559S00019951Western HFD Chow M
SA038560S00019949Western HFD Chow M
SA038561S00019947Western HFD Chow M
SA038562S00019944Western HFD Chow M
SA038563S00019943Western HFD Chow M
Showing results 1 to 63 of 63