Summary of Study ST000675
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000477. The data can be accessed directly via it's Project DOI: 10.21228/M8D89S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000675 |
| Study Title | Effects of rosiglitazone treatment on lipid composition |
| Study Type | MS analysis |
| Study Summary | Reprograming of 'white' to 'brite' adipocytes with higher oxidative capacity and improved endocrine function represents a potentially important approach to address the dysfunctional adipocyte phenotypes in obesity. We find that chronic treatment with the PPAR? agonist (rosiglitazone, 1 uM for 7days in vitro) in white human adipose tissue induced metabolic changes. Our trancriptome analysis showed that higher mitochondrial and peroxisomal fatty acid oxidation pathways and other genes involved in lipid metabolism including (re)esterification are induced by rosiglitazone treatment. To understand the biochemical basis of brite vs. white human adipocytes, we will perform comprehensive metabolomic profiling of control and rosiglitazone treated tissues using unbiased lipidomics approach. |
| Institute | University of Michigan |
| Department | Biomedical Research Core Facilities |
| Laboratory | Metabolomics core |
| Last Name | Kachman |
| First Name | Maureen |
| Address | 6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714 |
| mkachman@med.umich.edu | |
| Phone | (734) 232-8175 |
| Submit Date | 2017-06-05 |
| Num Groups | 2 |
| Total Subjects | 4 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | wiff |
| Analysis Type Detail | LC-MS |
| Release Date | 2017-12-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | TYPE |
|---|---|---|
| SA038679 | S00022677 | control |
| SA038680 | S00022676 | control |
| SA038681 | S00022672 | control |
| SA038682 | S00022665 | control |
| SA038683 | S00022668 | control |
| SA038684 | S00022669 | control |
| SA038685 | S00022664 | control |
| SA038686 | S00022673 | control |
| SA038671 | S00022670 | Rosi |
| SA038672 | S00022671 | Rosi |
| SA038673 | S00022674 | Rosi |
| SA038674 | S00022675 | Rosi |
| SA038675 | S00022678 | Rosi |
| SA038676 | S00022679 | Rosi |
| SA038677 | S00022667 | Rosi |
| SA038678 | S00022666 | Rosi |
| Showing results 1 to 16 of 16 |
