Summary of Study ST001157

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000776. The data can be accessed directly via it's Project DOI: 10.21228/M8CH5C This work is supported by NIH grant, U2C- DK119886.

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Study IDST001157
Study TitleThe gut microbiota plays a central role to modulate the plasma metabolome in response to chronic Angiotensin II infusion (part-I)
Study SummarySix week old C57BL/6 conventional (mice with gut microbiota; conv, n=6) and germ-free (mice without gut microbiota; GF, n=6) mice were infused with angiotensin-II (AngII) for 4 weeks (400ng.kg-1.min-1; Alzet 1004). In parallel control groups, conv (n=6) and GF (n=6) mice received saline via minipumps. Our primary goal was to identify metabolites which were differentially regulated in conventional mice treated with AngII, but not in GF mice, indicating that these metabolites are microbial in origin. Following minipump implantation, animals were housed singly to prevent cross-contamination of microbiota. At the end of fourth week, feces and blood were collected. Both plasma and feces samples were processed and analyzed by using Liquid Chromatography-Tandem Mass Spectroscopy (LC-MS/MS) for metabolite detection (Metabolon).
Institute
Johns Hopkins University
Last NamePluznick
First NameJennifer
Address725 N. Wolfe St., WBSB 205, Baltimore, MD 21205
Emailjpluznick@jhmi.edu
Phone410 614 4660
Submit Date2019-03-20
Raw Data AvailableYes
Analysis Type DetailLC-MS
Release Date2019-05-15
Release Version1
Jennifer Pluznick Jennifer Pluznick
https://dx.doi.org/10.21228/M8CH5C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample TREATMENT
SA080318JHOP-05707Plasma Angiotensin II
SA080319JHOP-05706Plasma Angiotensin II
SA080320JHOP-05708Plasma Angiotensin II
SA080321JHOP-05716Plasma Angiotensin II
SA080322JHOP-05715Plasma Angiotensin II
SA080323JHOP-05705Plasma Angiotensin II
SA080324JHOP-05704Plasma Angiotensin II
SA080325JHOP-05720Plasma Angiotensin II
SA080326JHOP-05719Plasma Angiotensin II
SA080327JHOP-05718Plasma Angiotensin II
SA080328JHOP-05703Plasma Angiotensin II
SA080329JHOP-05717Plasma Angiotensin II
SA080330JHOP-05714Plasma Saline
SA080331JHOP-05713Plasma Saline
SA080332JHOP-05709Plasma Saline
SA080333JHOP-05700Plasma Saline
SA080334JHOP-05699Plasma Saline
SA080335JHOP-05698Plasma Saline
SA080336JHOP-05701Plasma Saline
SA080337JHOP-05702Plasma Saline
SA080338JHOP-05711Plasma Saline
SA080339JHOP-05710Plasma Saline
SA080340JHOP-05697Plasma Saline
SA080341JHOP-05712Plasma Saline
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