Summary of Study ST001287

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000869. The data can be accessed directly via it's Project DOI: 10.21228/M8C40P This work is supported by NIH grant, U2C- DK119886.


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Study IDST001287
Study TitleLuminal succinate in UC-HMA (human microbiota-associated) mice.
Study TypeMS analysis
Study SummaryPatients with ulcerative colitis (UC) are known to be at higher risk for Clostridium difficile (C. difficile) infection (CDI), and CDI in UC patients is recognized as a major clinical problem because it worsens UC outcome. In order to assess the role of gut dysbiosis, seen in UC patients, we have established a human microbiota-associated mouse model in which germ-free mice are colonized with gut microbiota from UC patients. Utilizing this model, we found that UC microbiota colonized HMA mice (UC-HMA mice) were susceptible to CDI. To address the mechanism by which UC-HMA mice are unable to acquire the colonization resistance against C. difficile, we analyzed the luminal metabolites in UC-HMA mice, especially in succinate which is a crucial metabolite doe the growth of C. difficile.
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Submit Date2019-12-11
Num Groups63
Total Subjects3
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2020-01-13
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Replication Treatment
SA093870S00034622#1 Ctrl
SA093871S00034623#1 Ctrl
SA093872S00034624#1 Ctrl
SA093873S00034625#1 SuccinateConsumingBacteria
SA093874S00034626#1 SuccinateConsumingBacteria
SA093875S00034630#2 Ctrl
SA093876S00034631#2 Ctrl
SA093877S00034628#2 Ctrl
SA093878S00034627#2 Ctrl
SA093879S00034629#2 Ctrl
SA093880S00034636#2 SuccinateConsumingBacteria
SA093881S00034635#2 SuccinateConsumingBacteria
SA093882S00034634#2 SuccinateConsumingBacteria
SA093883S00034632#2 SuccinateConsumingBacteria
SA093884S00034633#2 SuccinateConsumingBacteria
SA093885S00034642#3 Ctrl
SA093886S00034641#3 Ctrl
SA093887S00034643#3 Ctrl
SA093888S00034637#3 Ctrl
SA093889S00034640#3 Ctrl
SA093890S00034638#3 Ctrl
SA093891S00034639#3 Ctrl
SA093892S00034650#3 SuccinateConsumingBacteria
SA093893S00034651#3 SuccinateConsumingBacteria
SA093894S00034649#3 SuccinateConsumingBacteria
SA093895S00034647#3 SuccinateConsumingBacteria
SA093896S00034644#3 SuccinateConsumingBacteria
SA093897S00034645#3 SuccinateConsumingBacteria
SA093898S00034646#3 SuccinateConsumingBacteria
SA093899S00034648#3 SuccinateConsumingBacteria
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