Summary of Study ST001287
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000869. The data can be accessed directly via it's Project DOI: 10.21228/M8C40P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001287 |
Study Title | Luminal succinate in UC-HMA (human microbiota-associated) mice. |
Study Type | MS analysis |
Study Summary | Patients with ulcerative colitis (UC) are known to be at higher risk for Clostridium difficile (C. difficile) infection (CDI), and CDI in UC patients is recognized as a major clinical problem because it worsens UC outcome. In order to assess the role of gut dysbiosis, seen in UC patients, we have established a human microbiota-associated mouse model in which germ-free mice are colonized with gut microbiota from UC patients. Utilizing this model, we found that UC microbiota colonized HMA mice (UC-HMA mice) were susceptible to CDI. To address the mechanism by which UC-HMA mice are unable to acquire the colonization resistance against C. difficile, we analyzed the luminal metabolites in UC-HMA mice, especially in succinate which is a crucial metabolite doe the growth of C. difficile. |
Institute | University of Michigan |
Department | Biomedical Research Core Facilities |
Laboratory | Metabolomics core |
Last Name | Kachman |
First Name | Maureen |
Address | Ann Arbor, MI |
mkachman@med.umich.edu | |
Phone | 734-232-0842 |
Submit Date | 2019-12-11 |
Num Groups | 63 |
Total Subjects | 3 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2020-01-13 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
mb_sample_id | local_sample_id | Replication | Treatment |
---|---|---|---|
SA093870 | S00034622 | #1 | Ctrl |
SA093871 | S00034623 | #1 | Ctrl |
SA093872 | S00034624 | #1 | Ctrl |
SA093873 | S00034625 | #1 | SuccinateConsumingBacteria |
SA093874 | S00034626 | #1 | SuccinateConsumingBacteria |
SA093875 | S00034630 | #2 | Ctrl |
SA093876 | S00034631 | #2 | Ctrl |
SA093877 | S00034628 | #2 | Ctrl |
SA093878 | S00034627 | #2 | Ctrl |
SA093879 | S00034629 | #2 | Ctrl |
SA093880 | S00034636 | #2 | SuccinateConsumingBacteria |
SA093881 | S00034635 | #2 | SuccinateConsumingBacteria |
SA093882 | S00034634 | #2 | SuccinateConsumingBacteria |
SA093883 | S00034632 | #2 | SuccinateConsumingBacteria |
SA093884 | S00034633 | #2 | SuccinateConsumingBacteria |
SA093885 | S00034642 | #3 | Ctrl |
SA093886 | S00034641 | #3 | Ctrl |
SA093887 | S00034643 | #3 | Ctrl |
SA093888 | S00034637 | #3 | Ctrl |
SA093889 | S00034640 | #3 | Ctrl |
SA093890 | S00034638 | #3 | Ctrl |
SA093891 | S00034639 | #3 | Ctrl |
SA093892 | S00034650 | #3 | SuccinateConsumingBacteria |
SA093893 | S00034651 | #3 | SuccinateConsumingBacteria |
SA093894 | S00034649 | #3 | SuccinateConsumingBacteria |
SA093895 | S00034647 | #3 | SuccinateConsumingBacteria |
SA093896 | S00034644 | #3 | SuccinateConsumingBacteria |
SA093897 | S00034645 | #3 | SuccinateConsumingBacteria |
SA093898 | S00034646 | #3 | SuccinateConsumingBacteria |
SA093899 | S00034648 | #3 | SuccinateConsumingBacteria |
Showing results 1 to 30 of 30 |