Summary of Study ST001503

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001015. The data can be accessed directly via it's Project DOI: 10.21228/M8H40X This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001503
Study TitleMetabolomics reveals the protective effect of isosteviol sodium against multiple organ injury in septic mice - Kidney
Study SummarySepsis is a severe inflammatory disorder that can lead to multiple organ injury. Isosteviol sodium (STV-Na) is a terpenoid derived from stevioside that exerts anti-inflammatory, antioxidant and anticancer activities. However, the influence of STV-Na on sepsis remains unknown. Here, we assessed the potential effects of STV-Na on sepsis and multiple organ injury induced by lipopolysaccharide (LPS). We found that STV-Na increased the survival rate of mice treat with LPS, significantly improved the functions of the heart, lung, liver, and kidney, and reduced the production of inflammatory cytokines. Moreover, Multiorgan metabolomics analysis demonstrated that glutathione metabolism, purine metabolism, glycerophospholipid metabolism and pantothenate and CoA biosynthesis, were significantly altered by STV-Na. This study provides novel insights into the metabolite changes of multiple organ injury in septic mice, which may help characterize the underlying mechanism and provide an improved understanding of the therapeutic effects of STV-Na on sepsis.
Institute
Guangdong University of Technology
Last NameWang
First NameShanping
AddressNo. 100, Waihuan Xilu, Guangzhou Higher Education Mega Center, Panyu District,
Emailshanpingwang@outlook.com
Phone15521002792
Submit Date2020-09-29
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2021-03-01
Release Version1
Shanping Wang Shanping Wang
https://dx.doi.org/10.21228/M8H40X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA126528Ctrl-8Control
SA126529Ctrl-1Control
SA126530Ctrl-7Control
SA126531Ctrl-6Control
SA126532Ctrl-2Control
SA126533Ctrl-4Control
SA126534Ctrl-3Control
SA126535Ctrl-5Control
SA126536LPS-6Model
SA126537LPS-7Model
SA126538LPS-5Model
SA126539LPS-4Model
SA126540LPS-2Model
SA126541LPS-1Model
SA126542LPS-3Model
SA126543Dex-4Positive
SA126544Dex-3Positive
SA126545Dex-1Positive
SA126546Dex-5Positive
SA126547Dex-7Positive
SA126548Dex-8Positive
SA126549Dex-2Positive
SA126550Dex-6Positive
SA126551STV-1Treatment
SA126552STV-3Treatment
SA126553STV-2Treatment
SA126554STV-4Treatment
SA126555STV-5Treatment
SA126556STV-7Treatment
SA126557STV-6Treatment
SA126558STV-8Treatment
Showing results 1 to 31 of 31
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