Summary of Study ST001699

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001089. The data can be accessed directly via it's Project DOI: 10.21228/M8XT42 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001699
Study TitleA cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Muscle) part-I
Study SummaryAging is associated with distinct phenotypical, physiological, and functional changes, leading to the onset of disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we performed physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that the decline in gait speed as a function of age and frailty is associated with dramatic increases in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their substrate selection and metabolism towards redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual and organ levels.
Institute
National Institutes of Health
DepartmentNIA
LaboratoryExperimental Gerontology Section and Translational Gerontology Branch
Last Namede Cabo
First NameRafael
Address251 Bayview Blvd. Suite 100/Room 5C214. Baltimore, MD 21224
EmaildeCaboRa@grc.nia.nih.gov
Phone1-410-558-8510
Submit Date2021-02-11
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2021-03-01
Release Version1
Rafael de Cabo Rafael de Cabo
https://dx.doi.org/10.21228/M8XT42
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Age
SA1581845_GAS-R_005mid age
SA15818510_GAS-R_010mid age
SA15818630_GAS-R_030mid age
SA1581874_GAS-R_004mid age
SA15818814_GAS-R_014mid age
SA15818919_GAS-R_019mid age
SA15819012_GAS-R_012mid age
SA1581913_GAS-R_003old
SA1581929_GAS-R_009old
SA15819329_GAS-R_029old
SA1581948_GAS-R_008old
SA1581956_GAS-R_006old
SA15819615_GAS-R_015old
SA15819728_GAS-R_028old
SA1581982_GAS-R_002old
SA15819911_GAS-R_011old
SA15820027_GAS-R_027old
SA15820120_GAS-R_020old
SA15820224_GAS-R_024young
SA15820325_GAS-R_025young
SA15820426_GAS-R_026young
SA15820523_GAS-R_023young
SA1582067_GAS-R_007young
SA15820717_GAS-R_017young
SA15820813_GAS-R_013young
SA1582091_GAS-R_001young
SA15821016_GAS-R_016young
SA15821118_GAS-R_018young
SA15821221_GAS-R_021young
SA15821322_GAS-R_022young
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