Summary of Study ST002112

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001338. The data can be accessed directly via it's Project DOI: 10.21228/M8RX2S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002112
Study TitleGlobal, distinctive and personal changes in molecular and microbial profiles induced by specific fibers in humans (Untargeted)
Study SummaryDietary fibers act through the microbiome and improve cardiovascular health, metabolic disorders and cancer prevention. To understand health benefits of dietary fiber supplementation we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multi-omic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel and clinical measurements on healthy and insulin resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation, it provides insights into mechanisms behind fiber induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome.
Institute
Stanford University
Last NameLancaster
First NameSamuel
Address240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305
Emailslancast@stanford.edu
Phone6126004033
Submit Date2022-05-06
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-03-13
Release Version1
Samuel Lancaster Samuel Lancaster
https://dx.doi.org/10.21228/M8RX2S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Fiber Timepoint Sex
SA25137841Arabinoxylan 10 F
SA25137930Arabinoxylan 10 F
SA25138024Arabinoxylan 10 F
SA25138195Arabinoxylan 10 F
SA251382185Arabinoxylan 10 F
SA251383297Arabinoxylan 10 F
SA251384209Arabinoxylan 10 F
SA25138517Arabinoxylan 10 F
SA25138696Arabinoxylan 10 F
SA251387179Arabinoxylan 10 F
SA2513886Arabinoxylan 10 F
SA251389226Arabinoxylan 10 M
SA25139039Arabinoxylan 10 M
SA251391204Arabinoxylan 10 M
SA251392132Arabinoxylan 10 M
SA251393228Arabinoxylan 10 M
SA251394106Arabinoxylan 10 M
SA2513952Arabinoxylan 10 M
SA25139644Arabinoxylan 10 M
SA25139763Arabinoxylan 20 F
SA251398136Arabinoxylan 20 F
SA251399218Arabinoxylan 20 F
SA251400314Arabinoxylan 20 F
SA251401327Arabinoxylan 20 F
SA251402262Arabinoxylan 20 F
SA251403244Arabinoxylan 20 F
SA251404173Arabinoxylan 20 F
SA251405149Arabinoxylan 20 F
SA2514065Arabinoxylan 20 F
SA251407295Arabinoxylan 20 M
SA251408164Arabinoxylan 20 M
SA251409272Arabinoxylan 20 M
SA251410176Arabinoxylan 20 M
SA25141114Arabinoxylan 20 M
SA251412139Arabinoxylan 20 M
SA251413311Arabinoxylan 20 M
SA25141411Arabinoxylan 20 M
SA251415231Arabinoxylan 30 F
SA251416276Arabinoxylan 30 F
SA251417183Arabinoxylan 30 F
SA251418284Arabinoxylan 30 F
SA25141980Arabinoxylan 30 F
SA251420102Arabinoxylan 30 F
SA251421215Arabinoxylan 30 F
SA25142254Arabinoxylan 30 F
SA251423275Arabinoxylan 30 F
SA25142461Arabinoxylan 30 F
SA251425155Arabinoxylan 30 M
SA251426300Arabinoxylan 30 M
SA25142784Arabinoxylan 30 M
SA251428165Arabinoxylan 30 M
SA251429343Arabinoxylan 30 M
SA251430238Arabinoxylan 30 M
SA251431206Arabinoxylan 30 M
SA251432250Arabinoxylan 30 M
SA251433153Arabinoxylan Baseline F
SA251434192Arabinoxylan Baseline F
SA251435128Arabinoxylan Baseline F
SA251436211Arabinoxylan Baseline F
SA251437222Arabinoxylan Baseline F
SA251438328Arabinoxylan Baseline F
SA25143971Arabinoxylan Baseline F
SA25144055Arabinoxylan Baseline F
SA251441126Arabinoxylan Baseline F
SA251442116Arabinoxylan Baseline F
SA25144345Arabinoxylan Baseline M
SA251444287Arabinoxylan Baseline M
SA25144558Arabinoxylan Baseline M
SA251446245Arabinoxylan Baseline M
SA251447345Arabinoxylan Baseline M
SA251448320Arabinoxylan Baseline M
SA251449154Arabinoxylan Baseline M
SA251450335Arabinoxylan Baseline M
SA25145148Arabinoxylan Baseline M
SA251452279Arabinoxylan Month 1 M
SA251453158Arabinoxylan Month 1 M
SA251454325Arabinoxylan Month 2 M
SA251455263Arabinoxylan Month 2 M
SA251456273Arabinoxylan Month 3 M
SA251457271Arabinoxylan Month 3 M
SA25145887Arabinoxylan Washout D10 F
SA251459249Arabinoxylan Washout D10 F
SA251460348Arabinoxylan Washout D10 F
SA251461101Arabinoxylan Washout D10 F
SA251462180Arabinoxylan Washout D10 F
SA251463234Arabinoxylan Washout D10 F
SA251464170Arabinoxylan Washout D10 F
SA251465347Arabinoxylan Washout D10 F
SA25146626Arabinoxylan Washout D10 F
SA251467135Arabinoxylan Washout D10 F
SA251468137Arabinoxylan Washout D10 M
SA251469243Arabinoxylan Washout D10 M
SA251470292Arabinoxylan Washout D10 M
SA25147188Arabinoxylan Washout D10 M
SA251472354Arabinoxylan Washout D10 M
SA251473349Arabinoxylan Washout D10 M
SA25147451Arabinoxylan Washout D10 M
SA251475144Arabinoxylan Washout D30 M
SA251476264Arabinoxylan Washout D3 F
SA251477117Arabinoxylan Washout D3 F
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