Summary of Study ST002476

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001599. The data can be accessed directly via it's Project DOI: 10.21228/M8113P This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002476
Study TitleHigh body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Mouse)
Study SummaryWhile a common symptom of influenza and coronavirus disease 2019 (COVID-19) is fever, its physiological role on host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C increase host resistance to viral pathogens including influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. The gut microbiota-derived deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. Furthermore, the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamster from lethal SARS-CoV-2 infection. Moreover, we demonstrate that certain bile acids are reduced in the plasma of COVID-19 patients who developed moderate I/II disease compared with minor illness group. These findings uncover an unexpected mechanism by which virus-induced high fever increases host resistance to influenza virus and SARS-CoV-2 in a gut microbiota-dependent manner.
Keio University
Last NameFukuda
First NameShinji
AddressKakuganji 246-2, Mizukami, Tsuruoka City Yamagata,Japan
Submit Date2023-01-24
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailCE-MS
Release Date2023-03-10
Release Version2
Shinji Fukuda Shinji Fukuda application/zip

Select appropriate tab below to view additional metadata details:


Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Temp/Duration
SA2490281422C for 7 d
SA2490291322C for 7 d
SA2490301222C for 7 d
SA2490311522C for 7 d
SA2490321822C for 7 d
SA2490332022C for 7 d
SA2490341922C for 7 d
SA2490351122C for 7 d
SA2490361722C for 7 d
SA2490371622C for 7 d
SA2490382536C for 7 d
SA2490392436C for 7 d
SA2490402336C for 7 d
SA2490412636C for 7 d
SA2490422736C for 7 d
SA2490433036C for 7 d
SA2490442936C for 7 d
SA2490452836C for 7 d
SA2490462236C for 7 d
SA2490472136C for 7 d
SA24904874C for 7 d
SA24904984C for 7 d
SA24905094C for 7 d
SA24905124C for 7 d
SA24905214C for 7 d
SA24905364C for 7 d
SA24905434C for 7 d
SA24905544C for 7 d
SA24905654C for 7 d
SA249057104C for 7 d
Showing results 1 to 30 of 30