Summary of Study ST003400

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002106. The data can be accessed directly via it's Project DOI: 10.21228/M8D256 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003400
Study TitleA Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on Metabolomics and Microbiomics
Study SummaryDue to increasingly stringent regulations on bisphenol A (BPA) usage, its structurally similar counterpart, BPS, has become widely employed as the primary substitute in various industries such as food packaging. However, recent years have unveiled potential risks of obesity promotion and insulin resistance associated with BPS, particularly during early life stages, although its precise impact remains inadequately understood. Addressing these concerns, this study established a mouse model to investigate the effects of maternal BPS exposure during pregnancy and lactation, combined with offspring consumption of a high-fat diet. The research examined physiological indicators related to obesity and insulin resistance in offspring, evaluated pathological changes in vital organs including the heart, liver, pancreas, white adipose tissue (WAT), and brown adipose tissue (BAT), conducted metabolomics perturbation analysis across multiple organs, and performed microbiome analysis based on fecal samples. Finally, correlations between phenotype, metabolome, and microbiome were explored to unravel intergenerational effects and mechanisms under BPS exposure, aiming to identify potential biomarkers of its effects.
Institute
College of Marine Food and Biological Engineering, Jimei University
Last NameLi
First NameShuyin
AddressNo.185 Yinjiang Road,Jimei District,Xiamen City,Fujian Province,China
Email164000107@qq.com
Phone18750682266
Submit Date2024-08-02
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2024-09-03
Release Version1
Shuyin Li Shuyin Li
https://dx.doi.org/10.21228/M8D256
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id BPS Treatment Sample source
SA371592BLF-2670.05mg/kg/d Brown Adipose Tissue
SA371593BLF-2580.05mg/kg/d Brown Adipose Tissue
SA371594BLF-2610.05mg/kg/d Brown Adipose Tissue
SA371595BLF-2620.05mg/kg/d Brown Adipose Tissue
SA371596BLF-2630.05mg/kg/d Brown Adipose Tissue
SA371597BLF-2660.05mg/kg/d Brown Adipose Tissue
SA371598BLF-2640.05mg/kg/d Brown Adipose Tissue
SA371599BLM-2470.05mg/kg/d Brown Adipose Tissue
SA371600BLM-2520.05mg/kg/d Brown Adipose Tissue
SA371601BLM-2530.05mg/kg/d Brown Adipose Tissue
SA371602BLM-2550.05mg/kg/d Brown Adipose Tissue
SA371603BLM-2750.05mg/kg/d Brown Adipose Tissue
SA371604BLM-2780.05mg/kg/d Brown Adipose Tissue
SA371605BLM-2790.05mg/kg/d Brown Adipose Tissue
SA371606HLM-2470.05mg/kg/d Heart Tissue
SA371607HLF-2580.05mg/kg/d Heart Tissue
SA371608HLF-2610.05mg/kg/d Heart Tissue
SA371609HLF-2620.05mg/kg/d Heart Tissue
SA371610HLF-2640.05mg/kg/d Heart Tissue
SA371611HLF-2660.05mg/kg/d Heart Tissue
SA371612HLF-2670.05mg/kg/d Heart Tissue
SA371613HLF-2630.05mg/kg/d Heart Tissue
SA371614HLM-2520.05mg/kg/d Heart Tissue
SA371615HLM-2550.05mg/kg/d Heart Tissue
SA371616HLM-2750.05mg/kg/d Heart Tissue
SA371617HLM-2780.05mg/kg/d Heart Tissue
SA371618HLM-2790.05mg/kg/d Heart Tissue
SA371619HLM-2530.05mg/kg/d Heart Tissue
SA371620LLM-2470.05mg/kg/d Liver Tissue
SA371621LLM-2790.05mg/kg/d Liver Tissue
SA371622LLM-2550.05mg/kg/d Liver Tissue
SA371623LLM-2530.05mg/kg/d Liver Tissue
SA371624LLM-2520.05mg/kg/d Liver Tissue
SA371625LLF-2640.05mg/kg/d Liver Tissue
SA371626LLF-2670.05mg/kg/d Liver Tissue
SA371627LLF-2660.05mg/kg/d Liver Tissue
SA371628LLM-2750.05mg/kg/d Liver Tissue
SA371629LLF-2630.05mg/kg/d Liver Tissue
SA371630LLF-2620.05mg/kg/d Liver Tissue
SA371631LLF-2610.05mg/kg/d Liver Tissue
SA371632LLF-2580.05mg/kg/d Liver Tissue
SA371633LLM-2780.05mg/kg/d Liver Tissue
SA371634PLM-2550.05mg/kg/d Pancreas Tissue
SA371635PLM-2750.05mg/kg/d Pancreas Tissue
SA371636PLM-2530.05mg/kg/d Pancreas Tissue
SA371637PLM-2520.05mg/kg/d Pancreas Tissue
SA371638PLM-2470.05mg/kg/d Pancreas Tissue
SA371639PLF-2670.05mg/kg/d Pancreas Tissue
SA371640PLF-2660.05mg/kg/d Pancreas Tissue
SA371641PLF-2640.05mg/kg/d Pancreas Tissue
SA371642PLF-2630.05mg/kg/d Pancreas Tissue
SA371643PLF-2580.05mg/kg/d Pancreas Tissue
SA371644PLF-2610.05mg/kg/d Pancreas Tissue
SA371645PLM-2790.05mg/kg/d Pancreas Tissue
SA371646PLM-2780.05mg/kg/d Pancreas Tissue
SA371647PLF-2620.05mg/kg/d Pancreas Tissue
SA371648WLF-2580.05mg/kg/d White Adipose Tissue
SA371649WLM-2470.05mg/kg/d White Adipose Tissue
SA371650WLF-2620.05mg/kg/d White Adipose Tissue
SA371651WLF-2630.05mg/kg/d White Adipose Tissue
SA371652WLF-2640.05mg/kg/d White Adipose Tissue
SA371653WLF-2660.05mg/kg/d White Adipose Tissue
SA371654WLF-2670.05mg/kg/d White Adipose Tissue
SA371655WLF-2610.05mg/kg/d White Adipose Tissue
SA371656WLM-2520.05mg/kg/d White Adipose Tissue
SA371657WLM-2550.05mg/kg/d White Adipose Tissue
SA371658WLM-2750.05mg/kg/d White Adipose Tissue
SA371659WLM-2780.05mg/kg/d White Adipose Tissue
SA371660WLM-2790.05mg/kg/d White Adipose Tissue
SA371661WLM-2530.05mg/kg/d White Adipose Tissue
SA371662BHF-44175mg/kg/d Brown Adipose Tissue
SA371663BHM-2945mg/kg/d Brown Adipose Tissue
SA371664BHM-2905mg/kg/d Brown Adipose Tissue
SA371665BHM-2895mg/kg/d Brown Adipose Tissue
SA371666BHF-44385mg/kg/d Brown Adipose Tissue
SA371667BHF-44195mg/kg/d Brown Adipose Tissue
SA371668BHF-44185mg/kg/d Brown Adipose Tissue
SA371669BHF-3075mg/kg/d Brown Adipose Tissue
SA371670BHF-44165mg/kg/d Brown Adipose Tissue
SA371671BHF-44155mg/kg/d Brown Adipose Tissue
SA371672BHF-44135mg/kg/d Brown Adipose Tissue
SA371673BHF-3065mg/kg/d Brown Adipose Tissue
SA371674BHF-2995mg/kg/d Brown Adipose Tissue
SA371675BHF-2985mg/kg/d Brown Adipose Tissue
SA371676BHM-3015mg/kg/d Brown Adipose Tissue
SA371677BHF-2955mg/kg/d Brown Adipose Tissue
SA371678BHF-2975mg/kg/d Brown Adipose Tissue
SA371679BHM-3005mg/kg/d Brown Adipose Tissue
SA371680BHM-3055mg/kg/d Brown Adipose Tissue
SA371681BHM-44525mg/kg/d Brown Adipose Tissue
SA371682BHM-44345mg/kg/d Brown Adipose Tissue
SA371683BHM-44335mg/kg/d Brown Adipose Tissue
SA371684BHM-44325mg/kg/d Brown Adipose Tissue
SA371685BHM-44315mg/kg/d Brown Adipose Tissue
SA371686BHM-44275mg/kg/d Brown Adipose Tissue
SA371687BHM-44235mg/kg/d Brown Adipose Tissue
SA371688BHM-3045mg/kg/d Brown Adipose Tissue
SA371689HHF-2995mg/kg/d Heart Tissue
SA371690HHF-3075mg/kg/d Heart Tissue
SA371691HHF-3065mg/kg/d Heart Tissue
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