Summary of Study ST004264

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002691. The data can be accessed directly via it's Project DOI: 10.21228/M8T837 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST004264
Study TitleDynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus
Study TypeMS quantitative analysis
Study SummaryTo meet the challenge of wintering in place many high-latitude small mammals reduce energy demands through hibernation. In contrast, short-lived Eurasian common shrews, Sorex araneus, remain active and shrink, including energy-intensive organs in winter, regrowing in spring in an evolved strategy called Dehnel’s phenomenon. How this size change is linked to metabolic and regulatory changes to sustain their high metabolism is unknown. We analyzed metabolic, proteomic, and gene expression profiles spanning the entirety of Dehnel’s seasonal cycle in wild shrews. We show regulatory changes to oxidative phosphorylation and increased fatty acid metabolism during autumn-to-winter shrinkage, as previously found in hibernating species. But in shrews we also found upregulated winter expression of genes involved in gluconeogenesis: the biosynthesis of glucose from non-carbohydrate substrates. Co-expression models revealed changes in size and metabolic gene expression interconnect via FOXO signaling, whose overexpression reduces size and extends lifespan in many model organisms. We propose that while shifts in gluconeogenesis meet the challenge posed by high metabolic rate and active winter lifestyle, FOXO signaling is central to Dehnel’s phenomenon, with spring downregulation limiting lifespan in these shrews.
Institute
Aalborg University
DepartmentHealth Science and Technology
LaboratoryMolecular Pharmacology
Last NameZeng
First NameYuanyuan
AddressThulevej 34 Aalborg SØ, Aalborg, Aalborg, 9210, Denmark
Emailyuanyzeng@outlook.com
Phone+4555204123
Submit Date2025-09-16
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2025-11-03
Release Version1
Yuanyuan Zeng Yuanyuan Zeng
https://dx.doi.org/10.21228/M8T837
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Sorex araneus (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Group
SA497281FALLJUV20_1Blood FallJuveniles
SA497282FALLJUV20_2Blood FallJuveniles
SA497283FALLJUV20_3Blood FallJuveniles
SA497284FALLJUV20_4Blood FallJuveniles
SA497285SPRINGAD21_2Blood SpringAdults
SA497286SPRINGAD21_5Blood SpringAdults
SA497287SPRINGAD21_4Blood SpringAdults
SA497288SPRINGAD21_3Blood SpringAdults
SA497289SPRINGAD21_1Blood SpringAdults
SA497290SUMAD21_5Blood SummerAdults
SA497291SUMAD21_4Blood SummerAdults
SA497292SUMAD21_3Blood SummerAdults
SA497293SUMAD21_2Blood SummerAdults
SA497294SUMAD21_1Blood SummerAdults
SA497295SUMJUV20_1Blood SummerJuveniles
SA497296SUMJUV20_2Blood SummerJuveniles
SA497297SUMJUV20_5Blood SummerJuveniles
SA497298SUMJUV20_4Blood SummerJuveniles
SA497299SUMJUV20_3Blood SummerJuveniles
SA497300WINTERJUV21_5Blood WinterJuveniles
SA497301WINTERJUV21_3Blood WinterJuveniles
SA497302WINTERJUV21_2Blood WinterJuveniles
SA497303WINTERJUV21_1Blood WinterJuveniles
SA497304WINTERJUV21_4Blood WinterJuveniles
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