Summary of Study ST000168

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000146. The data can be accessed directly via it's Project DOI: 10.21228/M83G6X This work is supported by NIH grant, U2C- DK119886.

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Study IDST000168
Study TitleEffect of Insulin Sensitizer Therapy on Amino Acids and Their Metabolites
Study Typedrug + time course
Study SummaryWe previously reported the overall study design for the parent study [29]. The current report primarily examines the effect of three months of insulin sensitizer therapy on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese adults with fasting hyperglycemia, defined as either impaired fasting glucose or untreated diabetes [29]. Briefly, 25 drug naïve, Northern European American participants with fasting blood glucose concentrations of 108–180 mg/dL were randomized to receive either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = 12) or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect on hepatic insulin sensitivity and pioglitazone based on its effect on peripheral insulin sensitivity. Current use of hypoglycemic medications excluded participants from the present study.
Institute
Mayo Clinic
DepartmentEndocrinology
LaboratorySree Nair
Last NameNair
First NameSreekumaran
EmailDasari.Surendra@mayo.edu
Submit Date2015-05-21
Num Groups2
Total Subjects27
Raw Data AvailableNo
Analysis Type DetailLC-MS
Release Date2015-06-28
Release Version1
Sreekumaran Nair Sreekumaran Nair
https://dx.doi.org/10.21228/M83G6X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN000262
Analysis type MS
Chromatography type
Chromatography system Waters Acquity
Column
MS Type ESI
MS instrument type Triple quadrupole
MS instrument name Thermo Quantum Ultra
Ion Mode POSITIVE
Units uM

MS:

MS ID:MS000211
Analysis ID:AN000262
Instrument Name:Thermo Quantum Ultra
Instrument Type:Triple quadrupole
MS Type:ESI
Ion Mode:POSITIVE
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