Summary of Study ST001505
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001015. The data can be accessed directly via it's Project DOI: 10.21228/M8H40X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001505 |
| Study Title | Metabolomics reveals the protective effect of isosteviol sodium against multiple organ injury in septic mice - Plasma |
| Study Summary | Sepsis is a severe inflammatory disorder that can lead to multiple organ injury. Isosteviol sodium (STV-Na) is a terpenoid derived from stevioside that exerts anti-inflammatory, antioxidant and anticancer activities. However, the influence of STV-Na on sepsis remains unknown. Here, we assessed the potential effects of STV-Na on sepsis and multiple organ injury induced by lipopolysaccharide (LPS). We found that STV-Na increased the survival rate of mice treat with LPS, significantly improved the functions of the heart, lung, liver, and kidney, and reduced the production of inflammatory cytokines. Moreover, Multiorgan metabolomics analysis demonstrated that glutathione metabolism, purine metabolism, glycerophospholipid metabolism and pantothenate and CoA biosynthesis, were significantly altered by STV-Na. This study provides novel insights into the metabolite changes of multiple organ injury in septic mice, which may help characterize the underlying mechanism and provide an improved understanding of the therapeutic effects of STV-Na on sepsis. |
| Institute | Guangdong University of Technology |
| Last Name | Wang |
| First Name | Shanping |
| Address | No. 100, Waihuan Xilu, Guangzhou Higher Education Mega Center, Panyu District, |
| shanpingwang@outlook.com | |
| Phone | 15521002792 |
| Submit Date | 2020-09-29 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-03-01 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN002494 | AN002495 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Reversed phase | Reversed phase |
| Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
| Column | Waters Acquity BEH C18 (50 x 2.1mm,1.7um) | Waters Acquity BEH C18 (50 x 2.1mm,1.7um) |
| MS Type | ESI | ESI |
| MS instrument type | QTOF | QTOF |
| MS instrument name | Bruker TIMS TOF | Bruker TIMS TOF |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | Intensity | Intensity |
MS:
| MS ID: | MS002314 |
| Analysis ID: | AN002494 |
| Instrument Name: | Bruker TIMS TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | MSMS Progenesis QI 2.1 software EZinfo 3.0 software |
| Ion Mode: | POSITIVE |
| Analysis Protocol File: | shanpingwang_Analysis_Protocol.docx |
| MS ID: | MS002315 |
| Analysis ID: | AN002495 |
| Instrument Name: | Bruker TIMS TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | MSMS Progenesis QI 2.1 software EZinfo 3.0 software |
| Ion Mode: | NEGATIVE |
| Analysis Protocol File: | shanpingwang_Analysis_Protocol.docx |
