Summary of Study ST001750
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001122. The data can be accessed directly via it's Project DOI: 10.21228/M8P686 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001750 |
Study Title | Gut microbiome influence on metabolic 1 disease in HIV and high-risk populations |
Study Summary | Poor metabolic health, characterized by insulin resistance and dyslipidemia, is higher in people living with HIV (PLWH) and has been linked with inflammation, anti-retroviral therapy (ART) drugs, and ART-associated lipodystrophy (LD). Metabolic disease is associated with gut microbiome composition outside the context of HIV but has not been deeply explored in HIV infection nor in high-risk men who have sex with men (HR-MSM), who have a highly altered gut microbiome composition. Furthermore, the contribution of increased bacterial translocation and associated systemic inflammation that has been described in HIV-positive and HR-MSM individuals has not been explored. We used a multi-omic approach to explore relationships between gut microbes, immune phenotypes, diet, and metabolic health across ART-treated PLWH with and without LD; untreated PLWH; and HR-MSM. For PLWH on ART, we further explored associations with the plasma metabolome. |
Institute | University of Colorado Anschutz Medical Campus |
Last Name | Reisdorph |
First Name | Nichole |
Address | 12850 East Montview Blvd, Aurora, CO, 80045, USA |
nichole.reisdorph@cuanschutz.edu | |
Phone | 303-724-9234 |
Submit Date | 2021-04-24 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2021-05-04 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN002852 | AN002853 |
---|---|---|
Analysis type | MS | MS |
Chromatography type | HILIC | Reversed phase |
Chromatography system | Agilent 6545 QTOF | Agilent 6545 QTOF |
Column | Agilent InfinityLab Poroshell 120 HILIC-Z (100 x 2.1mm) | Agilent Zorbax RRHD SB-C18 (100 x 2.1mm,1.8um) |
MS Type | ESI | ESI |
MS instrument type | QTOF | QTOF |
MS instrument name | Agilent 6545 QTOF | new |
Ion Mode | POSITIVE | POSITIVE |
Units | Abundance (Mass Spectral Counts) | Abundance (Mass Spectral Counts) |
MS:
MS ID: | MS002645 |
Analysis ID: | AN002852 |
Instrument Name: | Agilent 6545 QTOF |
Instrument Type: | QTOF |
MS Type: | ESI |
MS Comments: | Methods_-_LCMS.pdf |
Ion Mode: | POSITIVE |
MS ID: | MS002646 |
Analysis ID: | AN002853 |
Instrument Name: | new |
Instrument Type: | QTOF |
MS Type: | ESI |
MS Comments: | Methods_-_LCMS.pdf |
Ion Mode: | POSITIVE |