Summary of Study ST001750

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001122. The data can be accessed directly via it's Project DOI: 10.21228/M8P686 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001750
Study TitleGut microbiome influence on metabolic 1 disease in HIV and high-risk populations
Study SummaryPoor metabolic health, characterized by insulin resistance and dyslipidemia, is higher in people living with HIV (PLWH) and has been linked with inflammation, anti-retroviral therapy (ART) drugs, and ART-associated lipodystrophy (LD). Metabolic disease is associated with gut microbiome composition outside the context of HIV but has not been deeply explored in HIV infection nor in high-risk men who have sex with men (HR-MSM), who have a highly altered gut microbiome composition. Furthermore, the contribution of increased bacterial translocation and associated systemic inflammation that has been described in HIV-positive and HR-MSM individuals has not been explored. We used a multi-omic approach to explore relationships between gut microbes, immune phenotypes, diet, and metabolic health across ART-treated PLWH with and without LD; untreated PLWH; and HR-MSM. For PLWH on ART, we further explored associations with the plasma metabolome.
Institute
University of Colorado Anschutz Medical Campus
Last NameReisdorph
First NameNichole
Address12850 East Montview Blvd, Aurora, CO, 80045, USA
Emailnichole.reisdorph@cuanschutz.edu
Phone303-724-9234
Submit Date2021-04-24
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2021-05-04
Release Version1
Nichole Reisdorph Nichole Reisdorph
https://dx.doi.org/10.21228/M8P686
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Combined analysis:

Analysis ID AN002852 AN002853
Analysis type MS MS
Chromatography type HILIC Reversed phase
Chromatography system Agilent 6545 QTOF Agilent 6545 QTOF
Column Agilent InfinityLab Poroshell 120 HILIC-Z (100 x 2.1mm) Agilent Zorbax RRHD SB-C18 (100 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6545 QTOF new
Ion Mode POSITIVE POSITIVE
Units Abundance (Mass Spectral Counts) Abundance (Mass Spectral Counts)

MS:

MS ID:MS002645
Analysis ID:AN002852
Instrument Name:Agilent 6545 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Methods_-_LCMS.pdf
Ion Mode:POSITIVE
  
MS ID:MS002646
Analysis ID:AN002853
Instrument Name:new
Instrument Type:QTOF
MS Type:ESI
MS Comments:Methods_-_LCMS.pdf
Ion Mode:POSITIVE
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