Summary of Study ST003400
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002106. The data can be accessed directly via it's Project DOI: 10.21228/M8D256 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003400 |
| Study Title | A Study on the Mechanism of Perinatal BPS Exposure Promoting Obesity Based on Metabolomics and Microbiomics |
| Study Summary | Due to increasingly stringent regulations on bisphenol A (BPA) usage, its structurally similar counterpart, BPS, has become widely employed as the primary substitute in various industries such as food packaging. However, recent years have unveiled potential risks of obesity promotion and insulin resistance associated with BPS, particularly during early life stages, although its precise impact remains inadequately understood. Addressing these concerns, this study established a mouse model to investigate the effects of maternal BPS exposure during pregnancy and lactation, combined with offspring consumption of a high-fat diet. The research examined physiological indicators related to obesity and insulin resistance in offspring, evaluated pathological changes in vital organs including the heart, liver, pancreas, white adipose tissue (WAT), and brown adipose tissue (BAT), conducted metabolomics perturbation analysis across multiple organs, and performed microbiome analysis based on fecal samples. Finally, correlations between phenotype, metabolome, and microbiome were explored to unravel intergenerational effects and mechanisms under BPS exposure, aiming to identify potential biomarkers of its effects. |
| Institute | College of Marine Food and Biological Engineering, Jimei University |
| Last Name | Li |
| First Name | Shuyin |
| Address | No.185 Yinjiang Road,Jimei District,Xiamen City,Fujian Province,China |
| 164000107@qq.com | |
| Phone | 18750682266 |
| Submit Date | 2024-08-02 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-09-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN005580 | AN005581 |
|---|---|---|
| Analysis type | MS | MS |
| Chromatography type | Reversed phase | Reversed phase |
| Chromatography system | Thermo Dionex Ultimate 3000 | Thermo Dionex Ultimate 3000 |
| Column | Waters ACQUITY UPLC HSS C18 (100 x 2.1mm,1.8um) | ACE Excel 2 C18-PFP (100 x 2.1mm,2um) |
| MS Type | ESI | ESI |
| MS instrument type | Orbitrap | Orbitrap |
| MS instrument name | Thermo Q Exactive HF-X Orbitrap | Thermo Q Exactive HF-X Orbitrap |
| Ion Mode | POSITIVE | NEGATIVE |
| Units | Peak area | Peak area |
MS:
| MS ID: | MS005305 |
| Analysis ID: | AN005580 |
| Instrument Name: | Thermo Q Exactive HF-X Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | Xcalibular |
| Ion Mode: | POSITIVE |
| MS ID: | MS005306 |
| Analysis ID: | AN005581 |
| Instrument Name: | Thermo Q Exactive HF-X Orbitrap |
| Instrument Type: | Orbitrap |
| MS Type: | ESI |
| MS Comments: | Xcalibular |
| Ion Mode: | NEGATIVE |
