Summary of Study ST000939

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000648. The data can be accessed directly via it's Project DOI: 10.21228/M8X38B This work is supported by NIH grant, U2C- DK119886.


This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST000939
Study TitlePredicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome using Plasma Metabolomics
Study TypeDiscovery Metabolomics
Study SummaryPaired citrate plasma samples were collected from 27 steroid-sensitive and 14 steroid-resistant nephrotic syndrome participants prior to beginning treatment and after an average of 7 weeks (range 3-19 wks) of treatment with a corticosteroid.
RTI International
LaboratoryNIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC)
Last NameSumner
First NameSusan
Address3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA
Submit Date2018-03-01
Total Subjects86
Study CommentsFactor Description 1. Treatment Response R = Steroid Resistant; S = Steroid Sensitive; Steroid resistance was defined as failure to enter complete remission after 6-8 weeks of daily oral steroids; Steroid sensitive was defined as clinical remission after 6-8 weeks of daily oral steroids. 2. Draw Number Draw 1 sample, ‘Pre’, was collected at the time of disease presentation before even a single dose of glucocorticoids, and Draw 2 sample, ‘Post’, was collected after 6-10 weeks of Glucocorticoid therapy. 3. Age Age in years at the time of Draw 1, or 'Pre', sample collection Other sample data Weeks difference Time in weeks between draw 1, 'pre', and draw 2, 'post', treatment sample collection Gender M = male; F = female Race self-reported (Native American or Alaskan Native/Asian/Black or African American/Native Hawaiian or Other Pacific Islander/White/More than one race) Ethnicity self-reported (Hispanic or Latino/Not Hispanic or Latino/Unknown)
Raw Data AvailableYes
Analysis Type DetailNMR
Release Date2019-03-06
Release Version1
Susan Sumner Susan Sumner application/zip

Select appropriate tab below to view additional metadata details:


NMR ID:NM000119
Analysis ID:AN001540
Instrument Name:Bruker Avance III
Instrument Type:FT-NMR
NMR Experiment Type:1D 1H
Field Frequency Lock:Deuterium
Standard Concentration:1 mM
Spectrometer Frequency:700 MHz
NMR Solvent:D2O
NMR Tube Size:3 mm
Shimming Method:topshim
Pulse Sequence:cpmgpr1d
Water Suppression:Yes
Pulse Width:12.781 us
Power Level:19 W
Receiver Gain:4
Offset Frequency:3294.20 Hz
Chemical Shift Ref Cpd:formate
Number Of Scans:128
Dummy Scans:4
Acquisition Time:3.892 s
Relaxation Delay:2 s
Spectral Width:12 ppm
Num Data Points Acquired:65536
Real Data Points:65536
Line Broadening:0.5 Hz
Zero Filling:yes
Baseline Correction Method:Polynomial
Chemical Shift Ref Std:Formate
Binned Increment:0.04
Binned Data Excluded Range:water (4.55 – 5.15 ppm) and citrate (2.47-2.565 and 2.61-2.70)