Summary of Study ST000939
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000648. The data can be accessed directly via it's Project DOI: 10.21228/M8X38B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST000939 |
| Study Title | Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome using Plasma Metabolomics |
| Study Type | Discovery Metabolomics |
| Study Summary | Paired citrate plasma samples were collected from 27 steroid-sensitive and 14 steroid-resistant nephrotic syndrome participants prior to beginning treatment and after an average of 7 weeks (range 3-19 wks) of treatment with a corticosteroid. |
| Institute | RTI International |
| Department | Discovery-Science-Technology |
| Laboratory | NIH Eastern Regional Comprehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC) |
| Last Name | Sumner |
| First Name | Susan |
| Address | 3040 E. Cornwallis Road, Research Triangle Park, NC 27709, USA |
| susan_sumner@unc.edu | |
| Phone | 704-250-5000 |
| Submit Date | 2018-03-01 |
| Total Subjects | 86 |
| Study Comments | Factor Description 1. Treatment Response R = Steroid Resistant; S = Steroid Sensitive; Steroid resistance was defined as failure to enter complete remission after 6-8 weeks of daily oral steroids; Steroid sensitive was defined as clinical remission after 6-8 weeks of daily oral steroids. 2. Draw Number Draw 1 sample, ‘Pre’, was collected at the time of disease presentation before even a single dose of glucocorticoids, and Draw 2 sample, ‘Post’, was collected after 6-10 weeks of Glucocorticoid therapy. 3. Age Age in years at the time of Draw 1, or 'Pre', sample collection Other sample data Weeks difference Time in weeks between draw 1, 'pre', and draw 2, 'post', treatment sample collection Gender M = male; F = female Race self-reported (Native American or Alaskan Native/Asian/Black or African American/Native Hawaiian or Other Pacific Islander/White/More than one race) Ethnicity self-reported (Hispanic or Latino/Not Hispanic or Latino/Unknown) |
| Raw Data Available | Yes |
| Analysis Type Detail | NMR |
| Release Date | 2019-03-06 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
NMR:
| NMR ID: | NM000119 |
| Analysis ID: | AN001540 |
| Instrument Name: | Bruker Avance III |
| Instrument Type: | FT-NMR |
| NMR Experiment Type: | 1D 1H |
| Field Frequency Lock: | Deuterium |
| Standard Concentration: | 1 mM |
| Spectrometer Frequency: | 700 MHz |
| NMR Probe: | CRYO QNP |
| NMR Solvent: | D2O |
| NMR Tube Size: | 3 mm |
| Shimming Method: | topshim |
| Pulse Sequence: | cpmgpr1d |
| Water Suppression: | Yes |
| Pulse Width: | 12.781 us |
| Power Level: | 19 W |
| Receiver Gain: | 4 |
| Offset Frequency: | 3294.20 Hz |
| Chemical Shift Ref Cpd: | formate |
| Temperature: | 25 |
| Number Of Scans: | 128 |
| Dummy Scans: | 4 |
| Acquisition Time: | 3.892 s |
| Relaxation Delay: | 2 s |
| Spectral Width: | 12 ppm |
| Num Data Points Acquired: | 65536 |
| Real Data Points: | 65536 |
| Line Broadening: | 0.5 Hz |
| Zero Filling: | yes |
| Apodization: | Lorentzian |
| Baseline Correction Method: | Polynomial |
| Chemical Shift Ref Std: | Formate |
| Binned Increment: | 0.04 |
| Binned Data Excluded Range: | water (4.55 – 5.15 ppm) and citrate (2.47-2.565 and 2.61-2.70) |
