Summary of Study ST001319

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000896. The data can be accessed directly via it's Project DOI: 10.21228/M8VX0Z This work is supported by NIH grant, U2C- DK119886.

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Study IDST001319
Study TitlePre-treatment L-Carnitine Pharmacometabolomics in Sepsis (CaPS) Patients
Study Typemultiple timepoints; patients with severe sepsis or septic shock treated with varying doses of L-carnitine or a saline placebo
Study Summaryphase II study of L-carnitine infusion for the treatment of vasopressor-dependent shock
Institute
University of Michigan
LaboratoryStringer NMR Metabolomics Laboratory
Last NameMcHugh
First NameCora
Address428 Church St, Ann Arbor, MI, 48103, USA
EmailNMRmetabolomics@umich.edu
Phone7343530164
Submit Date2020-02-07
Num Groups4
Total Subjects228
Num Males128
Num Females100
PublicationsThis submission is Phase II: https://www.ncbi.nlm.nih.gov/pubmed/30646314 doi: 10.1001/jamanetworkopen.2018.6076 Earlier Phase I: Metabolomics Workbench: doi: 10.21228/M8VM2M https://www.ncbi.nlm.nih.gov/pubmed/23851424 doi: 10.1177/0148607113495414
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2020-09-10
Release Version1
Cora McHugh Cora McHugh
https://dx.doi.org/10.21228/M8VX0Z
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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NMR:

NMR ID:NM000161
Analysis ID:AN002195
Instrument Name:Varian 11.74T
Instrument Type:FT-NMR
NMR Experiment Type:1D-1H
NMR Comments:Arrayed for water saturation frequency and 90deg. pulse width for each sample. Varian (now Agilent, Inc., Santa Clara, CA) 11.74 Tesla (500 MHz) NMR spectrometer
Spectrometer Frequency:500 MHz
NMR Probe:5-mm Agilent “One-probe
NMR Solvent:D20
NMR Tube Size:5mm
Shimming Method:Auto shim (gradient shimming)
Pulse Sequence:1 H,1 H-NOESY (commonly referred to as a 1D-NOESY or METNOESY)
Water Suppression:saturation at 80 Hz induced field strength
Pulse Width:~5.5ms, arrayed for in each sample
Temperature:25
Number Of Scans:32
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