Summary of Study ST000964

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000662. The data can be accessed directly via it's Project DOI: 10.21228/M83Q2T This work is supported by NIH grant, U2C- DK119886.


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Study IDST000964
Study TitleU13C Glucose Tracing of Young and Old Pancreatic Islets
Study SummaryPancreatic islets from young and old mice were traced with either 2.8mM or 16.8mM U13C glucose to determine the effect of age upon glucose metabolism in basal and stimulated states.
University of California, San Diego
Last NameWortham
First NameMatthew
Address2880 Torrey Pines Scenic Drive, Sanford Consortium for Regenerative Medicine, Room 3102
Submit Date2018-04-27
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS
Release Date2019-04-27
Release Version1
Matthew Wortham Matthew Wortham application/zip

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Project ID:PR000662
Project DOI:doi: 10.21228/M83Q2T
Project Title:Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic beta cell function
Project Summary:Aging is associated with fundamental changes in pancreatic β-cell physiology; yet, the mechanisms that drive these age-related changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from adolescent and old mice. Nutrient tracing and targeted metabolomics demonstrated accelerated accumulation of glucose-derived metabolites and coupling factors in aged islets, indicating that age-related changes in glucose metabolism contribute to improved glucose-stimulated insulin secretion with age. Together, our study provides the first in-depth characterization of age-related changes in the islet proteome and establishes metabolic rewiring as an important mechanism for age-associated changes in β-cell function.
Institute:University of California, San Diego
Last Name:Wortham
First Name:Matthew
Address:2880 Torrey Pines Scenic Drive, Sanford Consortium for Regenerative Medicine, Room 3102, La Jolla, California, 92037, USA