Summary of Study ST001313

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000890. The data can be accessed directly via it's Project DOI: 10.21228/M8ND7K This work is supported by NIH grant, U2C- DK119886.


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Study IDST001313
Study TitleLipid expression in serum after early life exposure to an endocrine disruptor and a Western Diet at 240 days postnatal (part-IV)
Study TypeLipid expression after chemical exposure versus control
Study SummaryOur early-life environment has a profound influence on developing organs that impact metabolic function and determines disease susceptibility across the life-course. Using a rat model for exposure to an endocrine disrupting chemical (EDC), we show that early-life exposure causes metabolic dysfunction in adulthood and reprograms histone marks in the developing liver to accelerate acquisition of an adult epigenomic signature. This epigenomic reprogramming persists long after the initial exposure, but many reprogrammed genes remain transcriptionally silent with their impact on metabolism not revealed until a later life exposure to a Western-style diet. Diet-dependent metabolic disruption was largely driven by reprogramming of the Early Growth Response 1 (EGR1) transcriptome and production of metabolites in pathways linked to cholesterol, lipid and one-carbon metabolism. These findings demonstrate the importance of epigenome:environment interactions, which early in life accelerate epigenomic aging, and later in adulthood unlock metabolically restricted epigenetic reprogramming to drive metabolic dysfunction.
Baylor College of Medicine
Last NameWalker
First NameCheryl
Address1 Baylor Plaza, Houston, TX, 77030, USA
Submit Date2020-01-24
Num Groups2
Total Subjects10
Num Males10
Analysis Type DetailLC-MS
Release Date2020-03-11
Release Version1
Cheryl Walker Cheryl Walker application/zip

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Project ID:PR000890
Project DOI:doi: 10.21228/M8ND7K
Project Title:Metabolite and lipid profiling after early-life exposure to an endocrine disrupting chemical.
Project Type:Targeted and Untargeted MS analysis
Project Summary:Metabolic profiling in serum and liver tissue after early-life exposure to an endocrine disrupting chemical.
Institute:Baylor College of Medicine
Last Name:Walker
First Name:Cheryl
Address:1 Baylor Plaza, Houston, TX, 77030, USA