Summary of Study ST002341
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001503. The data can be accessed directly via it's Project DOI: 10.21228/M8DQ5R This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002341 |
| Study Title | Metabolomic analysis of colorectal cancer cells using mass spectrometry |
| Study Summary | Colorectal cancer (CRC) is one of the most prevalent tumors, with a high mortality rate. Nearly half of CRC patients develop metastasis, which accounts for as many as 90% of CRC-related deaths. In the metastasis process, cancer cells exhibit altered dependency on specific metabolic pathways and some of the metabolites discovered might be useful as potential diagnostic biomarkers. To identify metabolic pathway dependencies in CRC metastasis, mass spectrometry-based untargeted metabolomic analysis was performed in two pairs of CRC cell lines with different metastatic abilities. Each pair of cell lines was comprised of primary and metastatic colorectal cancer cell lines (SW480 vs. SW620; HT-29 vs. COLO 205). Relative levels of intracellular metabolites distinguished high-metastatic CRC cells from low-metastatic CRC cells. |
| Institute | Nanjing Medical University |
| Last Name | Zhang |
| First Name | Wenjun |
| Address | 101Longmian Avenue, Jiangning District, Nanjing 211166, P.R. China |
| zwj941027369@163.com | |
| Phone | +86-025-86868326 |
| Submit Date | 2022-10-06 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-11-28 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001503 |
| Project DOI: | doi: 10.21228/M8DQ5R |
| Project Title: | Metabolomic analysis of colorectal cancer cells using mass spectrometry |
| Project Summary: | Two pairs of human colorectal cancer cell lines with different metastatic abilities (SW480 vs SW620, HT-29 vs COLO-205) were used to screen differential metabolites. |
| Institute: | Nanjing Medical University |
| Last Name: | Zhang |
| First Name: | Wenjun |
| Address: | 101Longmian Avenue, Jiangning District, Nanjing 211166, P.R. China |
| Email: | zwj941027369@163.com |
| Phone: | +86-025-86868326 |
