Summary of Study ST000233

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000120. The data can be accessed directly via it's Project DOI: 10.21228/M82P4X This work is supported by NIH grant, U2C- DK119886.

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Study IDST000233
Study TitleMetabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice (Part II)
Study TypeTime course
Study Summary12 C57BL/6J male mice were acclimatized for 1 week and then divided into two groups and trained to eat dough pills. One group was control and the other was exposed to TCDF through the dough pills. The mice were treated for 5 days at a dosage .15μg of TCDF for a final concentration of 5μg/kg body weight. Also looked at were AHR-/- mice and they were treated the same way as the C57BL/6J mice.
Institute
Pennsylvania State University
DepartmentDepartment of Veterinary and Biomedical Sciences
Last NamePatterson
First NameAndrew
Address101 Life Sciences, University Park, State college, 16802
Emailrgn5011@psu.edu
Submit Date2015-07-07
Raw Data AvailableYes
Raw Data File Type(s)d
Uploaded File Size256 MB
Analysis Type DetailGC-MS
Release Date2015-08-14
Release Version1
Andrew Patterson Andrew Patterson
https://dx.doi.org/10.21228/M82P4X
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Sample Preparation:

Sampleprep ID:SP000256
Sampleprep Protocol Filename:GC_Sample_Prep.docx
Processing Method:Homogenization
Extraction Method:Methanol-Chloroform
Extract Enrichment:centerfugation
Extract Cleanup:bottom layer was dried with N2 gas, resuspended in MEOH/HCL and then hexane and saline, top layer was collected
Sample Resuspension:resuspended in hexane
Sample Spiking:C15:0 free acid and methy ester of C17:0 at 5 ?L
Organ:Liver
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