Summary of Study ST000189

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000160. The data can be accessed directly via it's Project DOI: 10.21228/M8JG6Z This work is supported by NIH grant, U2C- DK119886.


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Study IDST000189
Study TitleHirschprung Enterocolitis SCFA
Study TypeShort-chain fatty acid analysis
Study SummaryChildren with Hirschsprung disease (HD) who have a history of enterocolitis (HAEC) have a shift in colonic microbiota, many of which are necessary for short chain fatty acid (SCFA) production. As SCFAs play a critical role in colonic mucosal preservation, we hypothesized that fecal SCFA composition is altered in children with HAEC. Patients between age of 6 weeks and 16 years of age who were undergoing small bowel resection were selected, including those who were either receiving enteral nutrition preoperatively (control group), or those who were without enteral nutrition and receiving total parenteral nutrition (TPN group). At the time of operation, 100-500ยตl of effluent from the small bowel lumen was aspirated during the small bowel resection. The samples were immediately frozen in liquid nitrogen and stored at -80oC. Research is published:
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Submit Date2015-06-08
Num Groups1
Total Subjects20
Raw Data AvailableYes
Raw Data File Type(s)d
Uploaded File Size32 M
Analysis Type DetailGC-MS
Release Date2016-06-18
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Treatment ID:TR000216