Summary of Study ST000090

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000082. The data can be accessed directly via it's Project DOI: 10.21228/M8Z30M This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000090
Study TitleCaloric Restriction vs drugs
Study TypeComparison of caloric restriction vs medications that prolong life (Untargeted)
Study SummaryRapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our previous studies; maximal longevity was also increased in both sexes. Rapamycin increased lifespan more in females than in males at each dose evaluated, perhaps reflecting sexual dimorphism in blood levels of this drug. Some of the endocrine and metabolic changes seen in diet-restricted mice are not seen in mice exposed to rapamycin, and the pattern of expression of hepatic genes involved in xenobiotic metabolism is also quite distinct in rapamycin-treated and diet-restricted mice, suggesting that these two interventions for extending mouse lifespan differ in many respects. Research is published, untargeted data not used in publication but project description is relevant: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032600/
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Email mkachman@umich.edu
Submit Date2014-07-16
Num Groups5
Total Subjects70
Raw Data AvailableYes
Raw Data File Type(s)d
Uploaded File Size24 G
Analysis Type DetailLC-MS
Release Date2014-07-30
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8Z30M
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000082
Project DOI:doi: 10.21228/M8Z30M
Project Title:Caloric restriction Studies
Project Summary:Caloric restriction vs medications that prolong life
Institute:University of Michigan
Department:Internal Medicine
Laboratory:Burant Lab
Last Name:Beecher
First Name:Chris
Email:chrisbee@med.umich.edu
Phone:734-232-0815

Subject:

Subject ID:SU000109
Subject Type:Animal
Subject Species:Mus musculus
Taxonomy ID:10090
Species Group:Mammal

Factors:

Subject type: Animal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Treatment
SA004924S00011714Acarbose
SA004925S00011713Acarbose
SA004926S00011715Acarbose
SA004927S00011716Acarbose
SA004928S00011705Acarbose
SA004929S00011717Acarbose
SA004930S00011712Acarbose
SA004931S00011718Acarbose
SA004932S00011706Acarbose
SA004933S00011711Acarbose
SA004934S00011707Acarbose
SA004935S00011708Acarbose
SA004936S00011710Acarbose
SA004937S00011709Acarbose
SA004938S00011737Caloric restriction
SA004939S00011738Caloric restriction
SA004940S00011734Caloric restriction
SA004941S00011740Caloric restriction
SA004942S00011735Caloric restriction
SA004943S00011736Caloric restriction
SA004944S00011743Caloric restriction
SA004945S00011746Caloric restriction
SA004946S00011733Caloric restriction
SA004947S00011745Caloric restriction
SA004948S00011744Caloric restriction
SA004949S00011742Caloric restriction
SA004950S00011741Caloric restriction
SA004951S00011739Caloric restriction
SA004952S00011723Control
SA004953S00011724Control
SA004954S00011721Control
SA004955S00011720Control
SA004956S00011732Control
SA004957S00011719Control
SA004958S00011725Control
SA004959S00011722Control
SA004960S00011730Control
SA004961S00011726Control
SA004962S00011728Control
SA004963S00011729Control
SA004964S00011731Control
SA004965S00011727Control
SA004966S00011756Estrogen
SA004967S00011755Estrogen
SA004968S00011757Estrogen
SA004969S00011760Estrogen
SA004970S00011754Estrogen
SA004971S00011759Estrogen
SA004972S00011758Estrogen
SA004973S00011753Estrogen
SA004974S00011752Estrogen
SA004975S00011747Estrogen
SA004976S00011749Estrogen
SA004977S00011748Estrogen
SA004978S00011750Estrogen
SA004979S00011751Estrogen
SA004980S00011771Rapamycin
SA004981S00011769Rapamycin
SA004982S00011770Rapamycin
SA004983S00011774Rapamycin
SA004984S00011768Rapamycin
SA004985S00011773Rapamycin
SA004986S00011772Rapamycin
SA004987S00011764Rapamycin
SA004988S00011762Rapamycin
SA004989S00011761Rapamycin
SA004990S00011763Rapamycin
SA004991S00011765Rapamycin
SA004992S00011766Rapamycin
SA004993S00011767Rapamycin
Showing results 1 to 70 of 70

Collection:

Collection ID:CO000091
Collection Summary:-
Sample Type:Plasma

Treatment:

Treatment ID:TR000109

Sample Preparation:

Sampleprep ID:SP000104
Sampleprep Summary:-
Sampleprep Protocol Filename:Prep_Plasma_2APR2012_MAA.pdf

Combined analysis:

Analysis ID AN000143 AN000144
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent 1200 Agilent 1200
Column Waters Acquity HSS T3 Waters Acquity HSS T3
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode POSITIVE NEGATIVE
Units counts counts

Chromatography:

Chromatography ID:CH000102
Chromatography Summary:AQM003/AQM004
Methods Filename:Column1_solv1_jetstream+_grad9.m
Column1_solv2_jetstream-_grad9.m
Instrument Name:Agilent 1200
Column Name:Waters Acquity HSS T3
Chromatography Type:Reversed phase

MS:

MS ID:MS000119
Analysis ID:AN000143
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
Acquisition Parameters File:Column1_solv1_jetstream+_grad9.m
Processing Parameters File:LCPosDataProcessing.m
  
MS ID:MS000120
Analysis ID:AN000144
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
Acquisition Parameters File:Column1_solv2_jetstream-_grad9.m
Processing Parameters File:LCNegDataProcessing.m
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