Summary of Study ST000695

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000492. The data can be accessed directly via it's Project DOI: 10.21228/M8G31N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000695
Study TitlePilot metabolomics study of aromatase inhibitor associated arthralgias
Study TypeMS analysis
Study SummaryThe goal of the experiment is untargeted metabolomic and shotgun lipidomic profiling of serum samples collected from 50 patients before patients initiated therapy with an aromatase inhibitor and again after 3 months of aromatase inhibitor therapy. Half of the patients discontinued treatment within 6 months because of development of arthralgias during therapy and half remained on therapy for at least 24 months without development of significant arthralgias. We plan to analyse effects of AI therapy on metabolomic and lipidomic profiles, and to investigate associations between changes in profiles and development of symptoms.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups11
Total Subjects51
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8G31N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000492
Project DOI:doi: 10.21228/M8G31N
Project Title:Metabolomic Profiles and aromatase inhibitor associated arthralgias
Project Type:MS analysis
Project Summary:Performing metabolomic and lipidomic profiling of patients before and after aromatase inhibitor therapy in order to investigate the mechanism of action of AI therapy and why a subset of patients develop arthralgias during therapy
Institute:University of Michigan
Department:Internal Medicine Hematology Oncology
Laboratory:Henry Lab
Last Name:Henry
First Name:Nora Lynn
Address:Ann Arbor, MI
Email:norahh@umich.edu
Phone:734-936-4991

Subject:

Subject ID:SU000718
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id CASE_CONTROL Chemotherapy Drug Race TIMEPOINT Tamoxyfen Taxane
SA039318S00016272Case N Exemestane Black 3 Month N N
SA039319S00016271Case N Exemestane Black Baseline N N
SA039320S00016304Case N Exemestane White 3 Month N N
SA039321S00016334Case N Exemestane White 3 Month N N
SA039322S00016330Case N Exemestane White 3 Month N N
SA039323S00016286Case N Exemestane White 3 Month Y N
SA039324S00016280Case N Exemestane White 3 Month Y N
SA039325S00016300Case N Exemestane White 3 Month Y N
SA039326S00016329Case N Exemestane White Baseline N N
SA039327S00016333Case N Exemestane White Baseline N N
SA039328S00016303Case N Exemestane White Baseline N N
SA039329S00016285Case N Exemestane White Baseline Y N
SA039330S00016279Case N Exemestane White Baseline Y N
SA039331S00016299Case N Exemestane White Baseline Y N
SA039332S00016284Case N Letrozole Black 3 Month N N
SA039333S00016283Case N Letrozole Black Baseline N N
SA039334S00016278Case N Letrozole White 3 Month N N
SA039335S00016308Case N Letrozole White 3 Month N N
SA039336S00016250Case N Letrozole White 3 Month Y N
SA039337S00016338Case N Letrozole White 3 Month Y N
SA039338S00016244Case N Letrozole White 3 Month Y N
SA039339S00016277Case N Letrozole White Baseline N N
SA039340S00016307Case N Letrozole White Baseline N N
SA039341S00016337Case N Letrozole White Baseline Y N
SA039342S00016249Case N Letrozole White Baseline Y N
SA039343S00016243Case N Letrozole White Baseline Y N
SA039344S00016310Case Y Exemestane Black 3 Month N Y
SA039345S00016309Case Y Exemestane Black Baseline N Y
SA039346S00016274Case Y Exemestane White 3 Month N Y
SA039347S00016320Case Y Exemestane White 3 Month N Y
SA039348S00016298Case Y Exemestane White 3 Month N Y
SA039349S00016316Case Y Exemestane White 3 Month N Y
SA039350S00016282Case Y Exemestane White 3 Month Y N
SA039351S00016336Case Y Exemestane White 3 Month Y N
SA039352S00016328Case Y Exemestane White 3 Month Y Y
SA039353S00016260Case Y Exemestane White 3 Month Y Y
SA039354S00016297Case Y Exemestane White Baseline N Y
SA039355S00016273Case Y Exemestane White Baseline N Y
SA039356S00016319Case Y Exemestane White Baseline N Y
SA039357S00016315Case Y Exemestane White Baseline N Y
SA039358S00016335Case Y Exemestane White Baseline Y N
SA039359S00016281Case Y Exemestane White Baseline Y N
SA039360S00016327Case Y Exemestane White Baseline Y Y
SA039361S00016259Case Y Exemestane White Baseline Y Y
SA039362S00016294Case Y Letrozole White 3 Month Y Y
SA039363S00016270Case Y Letrozole White 3 Month Y Y
SA039364S00016312Case Y Letrozole White 3 Month Y Y
SA039365S00016293Case Y Letrozole White Baseline Y Y
SA039366S00016311Case Y Letrozole White Baseline Y Y
SA039367S00016269Case Y Letrozole White Baseline Y Y
SA039368S00016292Control N Exemestane Black 3 Month Y N
SA039369S00016291Control N Exemestane Black Baseline Y N
SA039370S00016248Control N Exemestane White 3 Month N N
SA039371S00016262Control N Exemestane White 3 Month N N
SA039372S00016326Control N Exemestane White 3 Month N N
SA039373S00016296Control N Exemestane White 3 Month N N
SA039374S00016268Control N Exemestane White 3 Month N N
SA039375S00016332Control N Exemestane White 3 Month Y N
SA039376S00016267Control N Exemestane White Baseline N N
SA039377S00016261Control N Exemestane White Baseline N N
SA039378S00016325Control N Exemestane White Baseline N N
SA039379S00016247Control N Exemestane White Baseline N N
SA039380S00016295Control N Exemestane White Baseline N N
SA039381S00016331Control N Exemestane White Baseline Y N
SA039382S00016302Control N Letrozole Black 3 Month N N
SA039383S00016301Control N Letrozole Black Baseline N N
SA039384S00016266Control N Letrozole White 3 Month N N
SA039385S00016288Control N Letrozole White 3 Month N N
SA039386S00016242Control N Letrozole White 3 Month N N
SA039387S00016252Control N Letrozole White 3 Month Y N
SA039388S00016254Control N Letrozole White 3 Month Y N
SA039389S00016240Control N Letrozole White 3 Month Y N
SA039390S00016241Control N Letrozole White Baseline N N
SA039391S00016265Control N Letrozole White Baseline N N
SA039392S00016287Control N Letrozole White Baseline N N
SA039393S00016251Control N Letrozole White Baseline Y N
SA039394S00016239Control N Letrozole White Baseline Y N
SA039395S00016253Control N Letrozole White Baseline Y N
SA039396S00016322Control Y Exemestane White 3 Month N N
SA039397S00016258Control Y Exemestane White 3 Month N N
SA039398S00016264Control Y Exemestane White 3 Month N Y
SA039399S00016290Control Y Exemestane White 3 Month N Y
SA039400S00016306Control Y Exemestane White 3 Month Y N
SA039401S00016324Control Y Exemestane White 3 Month Y N
SA039402S00016314Control Y Exemestane White 3 Month Y N
SA039403S00016246Control Y Exemestane White 3 Month Y Y
SA039404S00016257Control Y Exemestane White Baseline N N
SA039405S00016321Control Y Exemestane White Baseline N N
SA039406S00016289Control Y Exemestane White Baseline N Y
SA039407S00016263Control Y Exemestane White Baseline N Y
SA039408S00016305Control Y Exemestane White Baseline Y N
SA039409S00016313Control Y Exemestane White Baseline Y N
SA039410S00016323Control Y Exemestane White Baseline Y N
SA039411S00016245Control Y Exemestane White Baseline Y Y
SA039412S00016256Control Y Letrozole White 3 Month Y N
SA039413S00016276Control Y Letrozole White 3 Month Y Y
SA039414S00016318Control Y Letrozole White 3 Month Y Y
SA039415S00016255Control Y Letrozole White Baseline Y N
SA039416S00016275Control Y Letrozole White Baseline Y Y
SA039417S00016317Control Y Letrozole White Baseline Y Y
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Collection:

Collection ID:CO000712
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000732
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000725
Sampleprep Summary:-
Sampleprep Protocol Filename:A003_-_Untargeted_Metabolomics.pdf

Combined analysis:

Analysis ID AN001075 AN001076 AN001077 AN001078
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent Agilent Shimadzu CTO-20A Nexera X2 Shimadzu CTO-20A Nexera X2
Column Waters Acquity HSS T3 (50 x 2.1mm,1.8um) Waters Acquity HSS T3 (50 x 2.1mm,1.8um) Waters Acquity HSS T3 (50 x 2.1mm,1.8um) Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF Triple TOF Triple TOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF ABI Sciex 5600+ TripleTOF ABI Sciex 5600+ TripleTOF
Ion Mode NEGATIVE POSITIVE NEGATIVE POSITIVE
Units peak area peak area peak area normalized peak area normalized

Chromatography:

Chromatography ID:CH000758
Instrument Name:Agilent
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH000759
Instrument Name:Shimadzu CTO-20A Nexera X2
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Column Temperature:55
Flow Rate:0.400uL/min
Solvent A:40% acetonitrile/60% water; 10 mM ammonium acetate
Solvent B:10% acetonitrile/5% water/85% isopropanol; 10 mM ammonium acetate
Chromatography Type:Reversed phase

MS:

MS ID:MS000970
Analysis ID:AN001075
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
  
MS ID:MS000971
Analysis ID:AN001076
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
  
MS ID:MS000972
Analysis ID:AN001077
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:NEGATIVE
Analysis Protocol File:A004_-_Shotgun_Lipidomics.pdf
  
MS ID:MS000973
Analysis ID:AN001078
Instrument Name:ABI Sciex 5600+ TripleTOF
Instrument Type:Triple TOF
MS Type:ESI
Ion Mode:POSITIVE
Analysis Protocol File:A004_-_Shotgun_Lipidomics.pdf
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