Summary of study ST000695

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000492. The data can be accessed directly via it's Project DOI: 10.21228/M8G31N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000695
Study TitlePilot metabolomics study of aromatase inhibitor associated arthralgias
Study TypeMS analysis
Study SummaryThe goal of the experiment is untargeted metabolomic and shotgun lipidomic profiling of serum samples collected from 50 patients before patients initiated therapy with an aromatase inhibitor and again after 3 months of aromatase inhibitor therapy. Half of the patients discontinued treatment within 6 months because of development of arthralgias during therapy and half remained on therapy for at least 24 months without development of significant arthralgias. We plan to analyse effects of AI therapy on metabolomic and lipidomic profiles, and to investigate associations between changes in profiles and development of symptoms.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups11
Total Subjects51
Raw Data AvailableYes
Raw Data File Type(s).wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8G31N
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000492
Project DOI:doi: 10.21228/M8G31N
Project Title:Metabolomic Profiles and aromatase inhibitor associated arthralgias
Project Type:MS analysis
Project Summary:Performing metabolomic and lipidomic profiling of patients before and after aromatase inhibitor therapy in order to investigate the mechanism of action of AI therapy and why a subset of patients develop arthralgias during therapy
Institute:University of Michigan
Department:Internal Medicine Hematology Oncology
Laboratory:Henry Lab
Last Name:Henry
First Name:Nora Lynn
Address:Ann Arbor, MI
Email:norahh@umich.edu
Phone:734-936-4991
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